Prevalence of chronic kidney disease based on estimated glomerular filtration rate and proteinuria in Icelandic adults

2.50
Hdl Handle:
http://hdl.handle.net/2336/2805
Title:
Prevalence of chronic kidney disease based on estimated glomerular filtration rate and proteinuria in Icelandic adults
Authors:
Viktorsdottir, Olof; Palsson, Runolfur; Andresdottir, Margret B; Aspelund, Thor; Gudnason, Vilmundur; Indridason, Olafur S
Citation:
Nephrol. Dial. Transplant. 2005, 20(9):1799-807
Issue Date:
1-Sep-2005
Abstract:
BACKGROUND: The purpose of this study was to compare three different equations to calculate estimated glomerular filtration rate (eGFR) based on serum creatinine (SCr) and to estimate the prevalence of chronic kidney disease (CKD) in the Icelandic population. METHODS: This was a cross-sectional study using data from the Reykjavik Heart Study. GFR was estimated with three equations: Equation I was based on 1/SCr; Equation II based on the Cockcroft-Gault equation; and Equation III was the modified MDRD equation. The eGFR calculated with Equation III and proteinuria were used to estimate the prevalence of CKD. The prevalence was age-standardized to the truncated world population. We used chi-square and ANCOVA to compare the group with low eGFR to age-matched controls. RESULTS: The subjects consisted of 9229 males and 10,027 females, aged 33-85 years. The equations performed very differently. Equation I showed women with higher eGFR than men and little change with age. Equation II showed men with higher eGFR than women and marked decline in eGFR with age. Equation III was similar to Equation II but the decline in eGFR with age was not as great. Regardless of the equation used, most subjects (63.7-80.7%) had an eGFR in the range of 60-89 ml/min/1.73 m2. Using Equation III, age-standardized prevalence of low eGFR for the population aged 35-80+ years was estimated to be 4.7 and 11.6% for men and women, respectively. The proportion of subjects with eGFR <60 ml/min/1.73 m2 increased with advancing age. An additional 2.39% of men and 0.89% of women had proteinuria. The prevalence of renal and cardiovascular risk factors including proteinuria, hypertension, lipid abnormalities and markers of inflammation was higher among those with low eGFR than age-matched controls. CONCLUSIONS: GFR estimates and the prevalence of CKD are dependent on the equation used to calculate eGFR. Unexpectedly, a low proportion of the Icelandic population had normal kidney function according to the eGFR regardless of the equation used. These equations may not be useful in epidemiological research.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://ndt.oxfordjournals.org/cgi/content/full/20/9/1799

Full metadata record

DC FieldValue Language
dc.contributor.authorViktorsdottir, Olof-
dc.contributor.authorPalsson, Runolfur-
dc.contributor.authorAndresdottir, Margret B-
dc.contributor.authorAspelund, Thor-
dc.contributor.authorGudnason, Vilmundur-
dc.contributor.authorIndridason, Olafur S-
dc.date.accessioned2006-05-17T15:24:53Z-
dc.date.available2006-05-17T15:24:53Z-
dc.date.issued2005-09-01-
dc.identifier.citationNephrol. Dial. Transplant. 2005, 20(9):1799-807en
dc.identifier.issn0931-0509-
dc.identifier.pmid15928100-
dc.identifier.doi10.1093/ndt/gfh914-
dc.identifier.otherNEP12en
dc.identifier.urihttp://hdl.handle.net/2336/2805-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: The purpose of this study was to compare three different equations to calculate estimated glomerular filtration rate (eGFR) based on serum creatinine (SCr) and to estimate the prevalence of chronic kidney disease (CKD) in the Icelandic population. METHODS: This was a cross-sectional study using data from the Reykjavik Heart Study. GFR was estimated with three equations: Equation I was based on 1/SCr; Equation II based on the Cockcroft-Gault equation; and Equation III was the modified MDRD equation. The eGFR calculated with Equation III and proteinuria were used to estimate the prevalence of CKD. The prevalence was age-standardized to the truncated world population. We used chi-square and ANCOVA to compare the group with low eGFR to age-matched controls. RESULTS: The subjects consisted of 9229 males and 10,027 females, aged 33-85 years. The equations performed very differently. Equation I showed women with higher eGFR than men and little change with age. Equation II showed men with higher eGFR than women and marked decline in eGFR with age. Equation III was similar to Equation II but the decline in eGFR with age was not as great. Regardless of the equation used, most subjects (63.7-80.7%) had an eGFR in the range of 60-89 ml/min/1.73 m2. Using Equation III, age-standardized prevalence of low eGFR for the population aged 35-80+ years was estimated to be 4.7 and 11.6% for men and women, respectively. The proportion of subjects with eGFR <60 ml/min/1.73 m2 increased with advancing age. An additional 2.39% of men and 0.89% of women had proteinuria. The prevalence of renal and cardiovascular risk factors including proteinuria, hypertension, lipid abnormalities and markers of inflammation was higher among those with low eGFR than age-matched controls. CONCLUSIONS: GFR estimates and the prevalence of CKD are dependent on the equation used to calculate eGFR. Unexpectedly, a low proportion of the Icelandic population had normal kidney function according to the eGFR regardless of the equation used. These equations may not be useful in epidemiological research.en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urlhttp://ndt.oxfordjournals.org/cgi/content/full/20/9/1799en
dc.subjectAdulten
dc.subjectAge Distributionen
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectBody Heighten
dc.subjectBody Weighten
dc.subjectChronic Diseaseen
dc.subjectCreatinine/blooden
dc.subjectFemaleen
dc.subjectGlomerular Filtration Rateen
dc.subjectHumansen
dc.subjectIceland/epidemiologyen
dc.subjectKidney Diseasesen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPrevalenceen
dc.subjectProteinuriaen
dc.subjectSex Characteristicsen
dc.titlePrevalence of chronic kidney disease based on estimated glomerular filtration rate and proteinuria in Icelandic adultsen
dc.typeArticleen
dc.format.digYES-

Related articles on PubMed

All Items in Hirsla are protected by copyright, with all rights reserved, unless otherwise indicated.