The advantage of mucosal immunization for polysaccharide-specific memory responses in early life

2.50
Hdl Handle:
http://hdl.handle.net/2336/2806
Title:
The advantage of mucosal immunization for polysaccharide-specific memory responses in early life
Authors:
Bjarnarson, Stefania P; Jakobsen, Håvard; Del Giudice, Giuseppe; Trannoy, Emanuelle; Siegrist, Claire-Anne; Jonsdottir, Ingileif
Citation:
Eur. J. Immunol. 2005, 35(4):1037-45
Issue Date:
2005
Abstract:
The aim of vaccination is to rapidly elicit protective immunity and generate memory for sustained protection. We studied the induction and persistence of polysaccharide (PS)-specific memory in neonatal and infant mice primed with pneumococcal conjugate (Pnc1-TT) by assessing the response to native pneumococcal PS (PPS-1), the kinetics of the PPS-1-specific IgG response to a second Pnc1-TT dose and affinity maturation. A subcutaneous (s.c.) Pnc1-TT booster induced a rapid increase in PPS-1-specific IgG, indicating efficient priming for memory by a single dose of Pnc1-TT already at 1 week of age. High levels were maintained for >12 weeks. However, a PPS-1 booster induced no response in neonatal or infant mice. The adjuvant LT-K63 significantly enhanced the IgG response and affinity to Pnc1-TT by both the s.c. and the intranasal (i.n.) route in all age groups. In neonatal and infant mice, PPS-1 and LT-K63 induced a booster response only when given i.n. following either s.c. or i.n. priming with Pnc1-TT and LT-K63. In contrast, PPS-1 with or without LT-K63 administered s.c. compromised the ongoing PPS-1-specific response elicited in neonatal mice by either s.c. or i.n. priming with Pnc1-TT and LT-K63. These results demonstrate the advantage of the mucosal route for elicitation of PS-specific memory responses in early life.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www3.interscience.wiley.com/cgi-bin/fulltext/110426354/HTMLSTART

Full metadata record

DC FieldValue Language
dc.contributor.authorBjarnarson, Stefania P-
dc.contributor.authorJakobsen, Håvard-
dc.contributor.authorDel Giudice, Giuseppe-
dc.contributor.authorTrannoy, Emanuelle-
dc.contributor.authorSiegrist, Claire-Anne-
dc.contributor.authorJonsdottir, Ingileif-
dc.date.accessioned2006-05-17T15:35:59Z-
dc.date.available2006-05-17T15:35:59Z-
dc.date.issued2005-
dc.identifier.citationEur. J. Immunol. 2005, 35(4):1037-45en
dc.identifier.issn0014-2980-
dc.identifier.pmid15756644-
dc.identifier.doi10.1002/eji.200425850-
dc.identifier.urihttp://hdl.handle.net/2336/2806-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractThe aim of vaccination is to rapidly elicit protective immunity and generate memory for sustained protection. We studied the induction and persistence of polysaccharide (PS)-specific memory in neonatal and infant mice primed with pneumococcal conjugate (Pnc1-TT) by assessing the response to native pneumococcal PS (PPS-1), the kinetics of the PPS-1-specific IgG response to a second Pnc1-TT dose and affinity maturation. A subcutaneous (s.c.) Pnc1-TT booster induced a rapid increase in PPS-1-specific IgG, indicating efficient priming for memory by a single dose of Pnc1-TT already at 1 week of age. High levels were maintained for >12 weeks. However, a PPS-1 booster induced no response in neonatal or infant mice. The adjuvant LT-K63 significantly enhanced the IgG response and affinity to Pnc1-TT by both the s.c. and the intranasal (i.n.) route in all age groups. In neonatal and infant mice, PPS-1 and LT-K63 induced a booster response only when given i.n. following either s.c. or i.n. priming with Pnc1-TT and LT-K63. In contrast, PPS-1 with or without LT-K63 administered s.c. compromised the ongoing PPS-1-specific response elicited in neonatal mice by either s.c. or i.n. priming with Pnc1-TT and LT-K63. These results demonstrate the advantage of the mucosal route for elicitation of PS-specific memory responses in early life.en
dc.language.isoenen
dc.publisherJohn Wiley & Sonsen
dc.relation.urlhttp://www3.interscience.wiley.com/cgi-bin/fulltext/110426354/HTMLSTARTen
dc.subjectMiceen
dc.subjectAnimalsen
dc.subjectBacterial Toxinsen
dc.subjectEnterotoxinsen
dc.subjectEscherichia coli Proteinsen
dc.subjectImmunity, Mucosalen
dc.subjectImmunologic Memoryen
dc.subjectPolysaccharides, Bacterialen
dc.subjectVaccinesen
dc.titleThe advantage of mucosal immunization for polysaccharide-specific memory responses in early lifeen
dc.typeArticleen
dc.identifier.journalEuropean journal of immunologyen
dc.format.digYES-

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