Body composition in young adult survivors of childhood acute lymphoblastic leukaemia

2.50
Hdl Handle:
http://hdl.handle.net/2336/2838
Title:
Body composition in young adult survivors of childhood acute lymphoblastic leukaemia
Authors:
Jarfelt, M; Lannering, B; Bosaeus, I; Johannsson, G; Bjarnason, R
Citation:
Eur. J. Endocrinol. 2005, 153(1):81-9
Issue Date:
1-Jul-2005
Abstract:
OBJECTIVE: Obesity is frequently reported in patients treated for childhood leukaemia. Obesity, particularly abdominal obesity, is one of the main characteristics of the metabolic syndrome and a risk factor for cardiovascular disease and non-insulin-dependent diabetes mellitus (NIDDM). DESIGN: All patients treated for acute lymphoblastic leukaemia (ALL) before the onset of puberty in the region of western Sweden, between 1973 and 1985, and in first remission, were included. 35 out of 47 patients aged 20-32 years participated. 19 patients had received cranial radiotherapy, and the median follow-up time was 20 years. The focus of this report was to study body composition and signs of the metabolic syndrome and correlate the findings to spontaneous growth hormone (GH) secretion. METHODS: Body composition was assessed using dual-energy X-ray absorbtiometry (DEXA). We analyzed serum concentrations of insulin, glucose, leptin and lipids. RESULTS: No patient was obese according to World Health Organization criteria (body mass index, BMI > or = 30 kg/m2) but one-third were overweight (BMI 25-29.9 kg/m2). The maximal GH peak during 24 h (GHmax) was correlated to percentage of total body fat (r = -0.42; P = 0.017), trunk fat (r = -0.5; P = 0.005) and fat-free mass (r = 0.42; P = 0.017). GHmax was also correlated to s-triglycerides (r = -0.54; P = 0.001), low-density lipoprotein-cholesterol (r = -0.382; P = 0.024) and high-density lipoprotein-cholesterol (r = 0.45; P = 0.007). CONCLUSIONS: We found little effect on BMI but an increased percentage of total body fat, especially trunk fat, and a tendency for an unfavourable lipid profile in adult survivors of childhood leukaemia. These findings were related to low endogenous GH secretion due to cranial irradiation.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.eje-online.org/cgi/content/abstract/153/1/81

Full metadata record

DC FieldValue Language
dc.contributor.authorJarfelt, M-
dc.contributor.authorLannering, B-
dc.contributor.authorBosaeus, I-
dc.contributor.authorJohannsson, G-
dc.contributor.authorBjarnason, R-
dc.date.accessioned2006-05-18T13:30:28Z-
dc.date.available2006-05-18T13:30:28Z-
dc.date.issued2005-07-01-
dc.identifier.citationEur. J. Endocrinol. 2005, 153(1):81-9en
dc.identifier.issn0804-4643-
dc.identifier.pmid15994749-
dc.identifier.doi10.1530/eje.1.01931-
dc.identifier.urihttp://hdl.handle.net/2336/2838-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVE: Obesity is frequently reported in patients treated for childhood leukaemia. Obesity, particularly abdominal obesity, is one of the main characteristics of the metabolic syndrome and a risk factor for cardiovascular disease and non-insulin-dependent diabetes mellitus (NIDDM). DESIGN: All patients treated for acute lymphoblastic leukaemia (ALL) before the onset of puberty in the region of western Sweden, between 1973 and 1985, and in first remission, were included. 35 out of 47 patients aged 20-32 years participated. 19 patients had received cranial radiotherapy, and the median follow-up time was 20 years. The focus of this report was to study body composition and signs of the metabolic syndrome and correlate the findings to spontaneous growth hormone (GH) secretion. METHODS: Body composition was assessed using dual-energy X-ray absorbtiometry (DEXA). We analyzed serum concentrations of insulin, glucose, leptin and lipids. RESULTS: No patient was obese according to World Health Organization criteria (body mass index, BMI > or = 30 kg/m2) but one-third were overweight (BMI 25-29.9 kg/m2). The maximal GH peak during 24 h (GHmax) was correlated to percentage of total body fat (r = -0.42; P = 0.017), trunk fat (r = -0.5; P = 0.005) and fat-free mass (r = 0.42; P = 0.017). GHmax was also correlated to s-triglycerides (r = -0.54; P = 0.001), low-density lipoprotein-cholesterol (r = -0.382; P = 0.024) and high-density lipoprotein-cholesterol (r = 0.45; P = 0.007). CONCLUSIONS: We found little effect on BMI but an increased percentage of total body fat, especially trunk fat, and a tendency for an unfavourable lipid profile in adult survivors of childhood leukaemia. These findings were related to low endogenous GH secretion due to cranial irradiation.en
dc.language.isoenen
dc.publisherBioScientificaen
dc.relation.urlhttp://www.eje-online.org/cgi/content/abstract/153/1/81en
dc.subjectBody Compositionen
dc.subjectAdipose Tissueen
dc.subjectAdulten
dc.subjectBody Mass Indexen
dc.subjectChild, Preschoolen
dc.subjectFollow-Up Studiesen
dc.subjectInsulin Resistanceen
dc.subjectLeptinen
dc.subjectMetabolic Syndrome Xen
dc.subjectObesityen
dc.subjectRemission Inductionen
dc.subjectRisk Factorsen
dc.subjectSurvivorsen
dc.subjectWaist-Hip Ratioen
dc.subjectInfanten
dc.titleBody composition in young adult survivors of childhood acute lymphoblastic leukaemiaen
dc.typeArticleen
dc.identifier.journalEuropean journal of endocrinology / European Federation of Endocrine Societiesen
dc.format.digYES-
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