Persistent organochlorines, sedentary occupation, obesity and human male subfertility

2.50
Hdl Handle:
http://hdl.handle.net/2336/2839
Title:
Persistent organochlorines, sedentary occupation, obesity and human male subfertility
Authors:
Magnusdottir, Elin V; Thorsteinsson, Tanja; Thorsteinsdottir, Sigridur; Heimisdottir, Maria; Olafsdottir, Kristin
Citation:
Hum. Reprod. 2005, 20(1):208-15
Issue Date:
1-Jan-2005
Abstract:
BACKGROUND: Studies have suggested that the quality of human semen has been declining over recent decades, presumably because of lifestyle or environmental factors. METHODS: Polychlorinated biphenyls and organochlorine pesticides were analysed in the plasma of 25 men with poor semen quality, 20 men with normal semen quality and idiopathic subfertility and 27 men with normal semen quality and female factor subfertility. Samples of seminal fluid were also analysed to assess the relationship between the levels in blood and semen. RESULTS: The results indicate no difference in the levels of organochlorines between the groups. The levels of organochlorines in seminal fluid were proportional to the levels in plasma, but approximately 40 times lower. Men with poor semen quality were three times more likely to be obese than men with normal semen quality. There was also a significant negative correlation between semen quality parameters and body mass index among men with normal semen quality. The prevalence of sedentary work was lowest among men with the best semen quality. CONCLUSIONS: Poor semen quality was found to be associated with sedentary work and obesity but not with plasma levels of persistent organochlorines. More research is needed to assess whether sedentary lifestyle and obesity are causal factors in the decline of semen quality.
Additional Links:
http://humrep.oxfordjournals.org/cgi/content/full/20/1/208

Full metadata record

DC FieldValue Language
dc.contributor.authorMagnusdottir, Elin V-
dc.contributor.authorThorsteinsson, Tanja-
dc.contributor.authorThorsteinsdottir, Sigridur-
dc.contributor.authorHeimisdottir, Maria-
dc.contributor.authorOlafsdottir, Kristin-
dc.date.accessioned2006-05-18T13:32:18Z-
dc.date.available2006-05-18T13:32:18Z-
dc.date.issued2005-01-01-
dc.identifier.citationHum. Reprod. 2005, 20(1):208-15en
dc.identifier.issn0268-1161-
dc.identifier.pmid15567884-
dc.identifier.doi10.1093/humrep/deh569-
dc.identifier.otherOAG12en
dc.identifier.urihttp://hdl.handle.net/2336/2839-
dc.description.abstractBACKGROUND: Studies have suggested that the quality of human semen has been declining over recent decades, presumably because of lifestyle or environmental factors. METHODS: Polychlorinated biphenyls and organochlorine pesticides were analysed in the plasma of 25 men with poor semen quality, 20 men with normal semen quality and idiopathic subfertility and 27 men with normal semen quality and female factor subfertility. Samples of seminal fluid were also analysed to assess the relationship between the levels in blood and semen. RESULTS: The results indicate no difference in the levels of organochlorines between the groups. The levels of organochlorines in seminal fluid were proportional to the levels in plasma, but approximately 40 times lower. Men with poor semen quality were three times more likely to be obese than men with normal semen quality. There was also a significant negative correlation between semen quality parameters and body mass index among men with normal semen quality. The prevalence of sedentary work was lowest among men with the best semen quality. CONCLUSIONS: Poor semen quality was found to be associated with sedentary work and obesity but not with plasma levels of persistent organochlorines. More research is needed to assess whether sedentary lifestyle and obesity are causal factors in the decline of semen quality.en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urlhttp://humrep.oxfordjournals.org/cgi/content/full/20/1/208en
dc.subjectAdulten
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectHydrocarbons, Chlorinateden
dc.subjectInfertility, Maleen
dc.subjectLife Styleen
dc.subjectMaleen
dc.subjectObesityen
dc.subjectOccupationsen
dc.subjectPesticidesen
dc.subjectPolychlorinated Biphenylsen
dc.subjectSemenen
dc.titlePersistent organochlorines, sedentary occupation, obesity and human male subfertilityen
dc.typeArticleen
dc.format.digYES-

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