Long-term results in children with AML: NOPHO-AML Study Group--report of three consecutive trials

2.50
Hdl Handle:
http://hdl.handle.net/2336/2840
Title:
Long-term results in children with AML: NOPHO-AML Study Group--report of three consecutive trials
Authors:
Lie, S O; Abrahamsson, J; Clausen, N; Forestier, E; Hasle, H; Hovi, L; Jonmundsson, G; Mellander, L; Siimes, M A; Yssing, M; Zeller, B; Gustafsson, G
Citation:
Leukemia 2005, 19(12):2090-100
Issue Date:
1-Dec-2005
Abstract:
In all, 447 children with acute myeloid leukaemia (AML) have been treated on three consecutive NOPHO studies from July 1984 to December 2001. NOPHO-AML 84 was of moderate intensity with an induction of three courses of cytarabine, 6-thioguanine and doxorubicin followed by four consolidation courses with high-dose cytarabine. The 5-year event-free survival (EFS), disease free survival (DFS) and overall survival (OS) were 29, 37 and 38%. NOPHO-AML 88 was of high intensity with the addition of etoposide and mitoxantrone in selected courses during induction and consolidation. The interval between the induction courses should be as short as possible, that is, time intensity was introduced. The 5-year EFS, DFS and OS were 41, 48 and 46%. In NOPHO-AML 93, the treatment was stratified according to response to first induction course. The protocol utilised the same induction blocks as NOPHO-AML 88, but after the first block, children with a hypoplastic, nonleukaemic bone marrow were allowed to recover before the second block. Consolidation was identical with NOPHO-AML 88. The 5-year EFS, DFS and OS in NOPHO-AML 93 were 48, 52 and 65%. The new NOPHO-AML protocol has been based on experiences from previous protocols with stratification of patients with regard to in vivo response and specific cytogenetic aberrations.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Link field
Additional Links:
http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18943404&site=ehost-live

Full metadata record

DC FieldValue Language
dc.contributor.authorLie, S O-
dc.contributor.authorAbrahamsson, J-
dc.contributor.authorClausen, N-
dc.contributor.authorForestier, E-
dc.contributor.authorHasle, H-
dc.contributor.authorHovi, L-
dc.contributor.authorJonmundsson, G-
dc.contributor.authorMellander, L-
dc.contributor.authorSiimes, M A-
dc.contributor.authorYssing, M-
dc.contributor.authorZeller, B-
dc.contributor.authorGustafsson, G-
dc.date.accessioned2006-05-18T13:36:13Z-
dc.date.available2006-05-18T13:36:13Z-
dc.date.issued2005-12-01-
dc.identifier.citationLeukemia 2005, 19(12):2090-100en
dc.identifier.issn0887-6924-
dc.identifier.pmid16304571-
dc.identifier.doi10.1038/sj.leu.2403962-
dc.identifier.urihttp://hdl.handle.net/2336/2840-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Link fielden
dc.description.abstractIn all, 447 children with acute myeloid leukaemia (AML) have been treated on three consecutive NOPHO studies from July 1984 to December 2001. NOPHO-AML 84 was of moderate intensity with an induction of three courses of cytarabine, 6-thioguanine and doxorubicin followed by four consolidation courses with high-dose cytarabine. The 5-year event-free survival (EFS), disease free survival (DFS) and overall survival (OS) were 29, 37 and 38%. NOPHO-AML 88 was of high intensity with the addition of etoposide and mitoxantrone in selected courses during induction and consolidation. The interval between the induction courses should be as short as possible, that is, time intensity was introduced. The 5-year EFS, DFS and OS were 41, 48 and 46%. In NOPHO-AML 93, the treatment was stratified according to response to first induction course. The protocol utilised the same induction blocks as NOPHO-AML 88, but after the first block, children with a hypoplastic, nonleukaemic bone marrow were allowed to recover before the second block. Consolidation was identical with NOPHO-AML 88. The 5-year EFS, DFS and OS in NOPHO-AML 93 were 48, 52 and 65%. The new NOPHO-AML protocol has been based on experiences from previous protocols with stratification of patients with regard to in vivo response and specific cytogenetic aberrations.en
dc.language.isoenen
dc.publisherNatureen
dc.relation.urlhttp://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=18943404&site=ehost-liveen
dc.subjectAcute Diseaseen
dc.subjectAdolescenten
dc.subjectAntineoplastic Protocolsen
dc.subjectAntineoplastic Combined Chemotherapy Protocolsen
dc.subjectBone Marrowen
dc.subjectChilden
dc.subjectDrug Administration Scheduleen
dc.subjectFollow-Up Studiesen
dc.subjectLeukemia, Myeloiden
dc.subjectRemission Inductionen
dc.subjectSurvival Analysisen
dc.subjectTreatment Outcomeen
dc.subjectInfanten
dc.titleLong-term results in children with AML: NOPHO-AML Study Group--report of three consecutive trialsen
dc.typeArticleen
dc.format.digYES-
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