Allergic diseases and asthma in relation to serum immunoglobulins and salivary immunoglobulin A in pre-school children: a follow-up community-based study

2.50
Hdl Handle:
http://hdl.handle.net/2336/2846
Title:
Allergic diseases and asthma in relation to serum immunoglobulins and salivary immunoglobulin A in pre-school children: a follow-up community-based study
Authors:
Luethviksson, B R; Arason, G J; Thorarensen, O; Ardal, B; Valdimarsson, H
Citation:
Clin. Exp. Allergy 2005, 35(1):64-9
Issue Date:
2005
Abstract:
BACKGROUND: We have previously reported an association between low IgA and allergic manifestations in early childhood (0-2 years) and have now followed our cohort for an additional 2 years. OBJECTIVE: To evaluate in a longitudinal community-based cohort study the association between maturation of Ig production and allergic manifestations in the first 4 years of life. METHODS: A cohort of 161 randomly selected children was followed from birth to the age of 42-48 months and evaluated at 18-23 months (EV1; n = 179) and again at the age of 42-48 months (EV2; n = 161). Diagnoses were made with the help of a clinical questionnaire, physical examination and skin prick tests (SPTs) to 10 common allergens. Serum immunoglobulins were measured at EV1 and EV2, and salivary IgA (sal-IgA) at EV2. RESULTS: Serum IgA, IgE, IgG1, IgG2 and IgG4 increased from 2 to 4 years of age (P < 0.001) and their levels showed close correlations (P < or = 0.01 for most comparisons). Children with one or more positive SPTs had lower serum IgA (P = 0.004) and IgG4 (P = 0.05) at EV2 than those who did not respond, and children who developed allergic rhinitis between EV1 and EV2 had low sal-IgA (P = 0.006) and IgG3 (P < 0.05) at EV2. Atopic eczema was associated with low sal-IgA at EV2, and children who developed eczema between EV1 and EV2 had significantly lower sal-IgA than those who recovered after EV1 (P = 0.02). CONCLUSION: Allergic manifestations in predisposed children may be influenced by the rate of maturation of immunological components that counteract sensitization or inhibit effector mechanisms of allergy.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Link field
Additional Links:
http://www.blackwell-synergy.com/doi/full/10.1111/j.1365-2222.2005.02141.x

Full metadata record

DC FieldValue Language
dc.contributor.authorLuethviksson, B R-
dc.contributor.authorArason, G J-
dc.contributor.authorThorarensen, O-
dc.contributor.authorArdal, B-
dc.contributor.authorValdimarsson, H-
dc.date.accessioned2006-05-18T14:16:00Z-
dc.date.available2006-05-18T14:16:00Z-
dc.date.issued2005-
dc.identifier.citationClin. Exp. Allergy 2005, 35(1):64-9en
dc.identifier.issn0954-7894-
dc.identifier.pmid15649268-
dc.identifier.doi10.1111/j.1365-2222.2005.02141.x-
dc.identifier.otherAAI12en
dc.identifier.urihttp://hdl.handle.net/2336/2846-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Link fielden
dc.description.abstractBACKGROUND: We have previously reported an association between low IgA and allergic manifestations in early childhood (0-2 years) and have now followed our cohort for an additional 2 years. OBJECTIVE: To evaluate in a longitudinal community-based cohort study the association between maturation of Ig production and allergic manifestations in the first 4 years of life. METHODS: A cohort of 161 randomly selected children was followed from birth to the age of 42-48 months and evaluated at 18-23 months (EV1; n = 179) and again at the age of 42-48 months (EV2; n = 161). Diagnoses were made with the help of a clinical questionnaire, physical examination and skin prick tests (SPTs) to 10 common allergens. Serum immunoglobulins were measured at EV1 and EV2, and salivary IgA (sal-IgA) at EV2. RESULTS: Serum IgA, IgE, IgG1, IgG2 and IgG4 increased from 2 to 4 years of age (P < 0.001) and their levels showed close correlations (P < or = 0.01 for most comparisons). Children with one or more positive SPTs had lower serum IgA (P = 0.004) and IgG4 (P = 0.05) at EV2 than those who did not respond, and children who developed allergic rhinitis between EV1 and EV2 had low sal-IgA (P = 0.006) and IgG3 (P < 0.05) at EV2. Atopic eczema was associated with low sal-IgA at EV2, and children who developed eczema between EV1 and EV2 had significantly lower sal-IgA than those who recovered after EV1 (P = 0.02). CONCLUSION: Allergic manifestations in predisposed children may be influenced by the rate of maturation of immunological components that counteract sensitization or inhibit effector mechanisms of allergy.en
dc.language.isoenen
dc.publisherBlackwellen
dc.relation.urlhttp://www.blackwell-synergy.com/doi/full/10.1111/j.1365-2222.2005.02141.xen
dc.subjectAsthmaen
dc.subjectChild, Preschoolen
dc.subjectComparative Studyen
dc.subjectDermatitis, Atopicen
dc.subjectFollow-Up Studiesen
dc.subjectHumansen
dc.subjectHypersensitivityen
dc.subjectImmunoglobulin Aen
dc.subjectImmunoglobulin Een
dc.subjectImmunoglobulin Gen
dc.subjectInfant, Newbornen
dc.subjectRhinitis, Allergic, Seasonalen
dc.subjectSalivaen
dc.subjectSkin Testsen
dc.subjectStatistics, Nonparametricen
dc.subjectTime Factorsen
dc.titleAllergic diseases and asthma in relation to serum immunoglobulins and salivary immunoglobulin A in pre-school children: a follow-up community-based studyen
dc.typeArticleen
dc.format.digYES-
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