2.50
Hdl Handle:
http://hdl.handle.net/2336/2863
Title:
Second primary malignancies in patients with male breast cancer
Authors:
Hemminki, K; Scélo, G; Boffetta, P; Mellemkjaer, L; Tracey, E; Andersen, A; Brewster, D H; Pukkala, E; McBride, M; Kliewer, E V; Chia, K-S; Pompe-Kirn, V; Martos, C; Jonasson, J G; Li, X; Brennan, P
Citation:
Br. J. Cancer 2005, 92(7):1288-92
Issue Date:
11-Apr-2005
Abstract:
An international multicentre study of first and second primary neoplasms associated with male breast cancer was carried out by pooling data from 13 cancer registries. Among a total of 3409 men with primary breast cancer, 426 (12.5%) developed a second neoplasia; other than breast cancer, a 34% overall excess risk of second primary neoplasia, affecting the small intestine (standardised incidence ratio, 4.95, 95% confidence interval, 1.35-12.7), rectum (1.78, 1.20-2.54), pancreas (1.93, 1.14-3.05), skin (nonmelanoma, 1.65, 1.16-2.29), prostate (1.61, 1.34-1.93) and lymphohaematopoietic system (1.63, 1.12-2.29). A total of 225 male breast cancers was recorded after cancers other than breast cancer, but an increase was found only after lymphohaematopoietic neoplasms. BRCA2 (and to some extent BRCA1) mutations may explain the findings for pancreatic and prostate cancers. Increases at other sites may be related to unknown factors or to chance. This large study shows that the risks for second discordant tumours after male breast cancer pose only a moderate excess risk.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Link field
Additional Links:
http://dx.doi.org/10.1038/sj.bjc.6602505

Full metadata record

DC FieldValue Language
dc.contributor.authorHemminki, K-
dc.contributor.authorScélo, G-
dc.contributor.authorBoffetta, P-
dc.contributor.authorMellemkjaer, L-
dc.contributor.authorTracey, E-
dc.contributor.authorAndersen, A-
dc.contributor.authorBrewster, D H-
dc.contributor.authorPukkala, E-
dc.contributor.authorMcBride, M-
dc.contributor.authorKliewer, E V-
dc.contributor.authorChia, K-S-
dc.contributor.authorPompe-Kirn, V-
dc.contributor.authorMartos, C-
dc.contributor.authorJonasson, J G-
dc.contributor.authorLi, X-
dc.contributor.authorBrennan, P-
dc.date.accessioned2006-05-19T10:20:23Z-
dc.date.available2006-05-19T10:20:23Z-
dc.date.issued2005-04-11-
dc.identifier.citationBr. J. Cancer 2005, 92(7):1288-92en
dc.identifier.issn0007-0920-
dc.identifier.pmid15798766-
dc.identifier.doi10.1038/sj.bjc.6602505-
dc.identifier.otherPTT12en
dc.identifier.urihttp://hdl.handle.net/2336/2863-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Link fielden
dc.description.abstractAn international multicentre study of first and second primary neoplasms associated with male breast cancer was carried out by pooling data from 13 cancer registries. Among a total of 3409 men with primary breast cancer, 426 (12.5%) developed a second neoplasia; other than breast cancer, a 34% overall excess risk of second primary neoplasia, affecting the small intestine (standardised incidence ratio, 4.95, 95% confidence interval, 1.35-12.7), rectum (1.78, 1.20-2.54), pancreas (1.93, 1.14-3.05), skin (nonmelanoma, 1.65, 1.16-2.29), prostate (1.61, 1.34-1.93) and lymphohaematopoietic system (1.63, 1.12-2.29). A total of 225 male breast cancers was recorded after cancers other than breast cancer, but an increase was found only after lymphohaematopoietic neoplasms. BRCA2 (and to some extent BRCA1) mutations may explain the findings for pancreatic and prostate cancers. Increases at other sites may be related to unknown factors or to chance. This large study shows that the risks for second discordant tumours after male breast cancer pose only a moderate excess risk.en
dc.language.isoenen
dc.publisherNature Publishing Group on behalf of Cancer Research UKen
dc.relation.urlhttp://dx.doi.org/10.1038/sj.bjc.6602505en
dc.subjectAdulten
dc.subjectAgeden
dc.subjectBreast Neoplasms, Maleen
dc.subjectFollow-Up Studiesen
dc.subjectIncidenceen
dc.subjectMiddle Ageden
dc.subjectNeoplasms, Second Primaryen
dc.subjectRegistriesen
dc.subjectRisk Factorsen
dc.titleSecond primary malignancies in patients with male breast canceren
dc.typeArticleen
dc.format.digYES-

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