Extensive intestinal metaplasia in gastric carcinoma and in other lesions requiring surgery: a study of 3,421 gastrectomy specimens from dwellers of the Atlantic and Pacific basins

2.50
Hdl Handle:
http://hdl.handle.net/2336/2866
Title:
Extensive intestinal metaplasia in gastric carcinoma and in other lesions requiring surgery: a study of 3,421 gastrectomy specimens from dwellers of the Atlantic and Pacific basins
Authors:
Rubio, C A; Jonasson, J; Nesi, G; Mandai, K; Pisano, R; King, A; Owen, D
Citation:
J. Clin. Pathol. 2005, 58(12):1271-7
Issue Date:
1-Dec-2005
Abstract:
BACKGROUND: Extensive intestinal metaplasia (EIM) has been reported in gastrectomies from patients dwelling in the Pacific and Atlantic basins.AIMS: To compare all the results in an attempt to explain the findings.Method: All sections from 3,421 gastrectomies were reviewed at various hospitals: 1946 in the Atlantic and 1475 in the Pacific basin. Sections with EIM showed IM encompassing one or more entire low power field (>or=5 mm in length/section) in one or more section.RESULTS: In the Atlantic basin, EIM was present in 18.8% (153 of 814) of specimens with intestinal carcinoma (IC) and in 10.3% (65 of 630) of those with diffuse carcinoma (DC). In the Pacific basin, EIM was found in 62.9% (412 of 655) of gastrectomies with IC and in 33.3% (160 of 481) of those with DC. The numbers of specimens with EIM were significantly higher in the Pacific than in the Atlantic basin for both carcinoma phenotypes, particularly among elderly patients (>or=60 years).CONCLUSIONS: The proportion of gastrectomies with EIM was higher among populations at a higher gastric cancer risk than in those with a lower cancer risk. EIM was mostly associated with IC rather than DC or with miscellaneous gastric diseases (841 control gastrectomies) in both basins. The proportion of gastrectomies with EIM was significantly higher in Vancouver than in New York and in Santiago de Chile than in Buenos Aires, even though these populations reside at approximately the same geographical latitude, but in different basins. Environmental factors seem to accelerate the evolution of EIM.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://jcp.bmjjournals.com/cgi/reprint/58/12/1271

Full metadata record

DC FieldValue Language
dc.contributor.authorRubio, C A-
dc.contributor.authorJonasson, J-
dc.contributor.authorNesi, G-
dc.contributor.authorMandai, K-
dc.contributor.authorPisano, R-
dc.contributor.authorKing, A-
dc.contributor.authorOwen, D-
dc.date.accessioned2006-05-19T10:51:39Z-
dc.date.available2006-05-19T10:51:39Z-
dc.date.issued2005-12-01-
dc.identifier.citationJ. Clin. Pathol. 2005, 58(12):1271-7en
dc.identifier.issn0021-9746-
dc.identifier.pmid16311346-
dc.identifier.doi10.1136/jcp.2005.029587-
dc.identifier.otherPPT12en
dc.identifier.urihttp://hdl.handle.net/2336/2866-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: Extensive intestinal metaplasia (EIM) has been reported in gastrectomies from patients dwelling in the Pacific and Atlantic basins.AIMS: To compare all the results in an attempt to explain the findings.Method: All sections from 3,421 gastrectomies were reviewed at various hospitals: 1946 in the Atlantic and 1475 in the Pacific basin. Sections with EIM showed IM encompassing one or more entire low power field (>or=5 mm in length/section) in one or more section.RESULTS: In the Atlantic basin, EIM was present in 18.8% (153 of 814) of specimens with intestinal carcinoma (IC) and in 10.3% (65 of 630) of those with diffuse carcinoma (DC). In the Pacific basin, EIM was found in 62.9% (412 of 655) of gastrectomies with IC and in 33.3% (160 of 481) of those with DC. The numbers of specimens with EIM were significantly higher in the Pacific than in the Atlantic basin for both carcinoma phenotypes, particularly among elderly patients (>or=60 years).CONCLUSIONS: The proportion of gastrectomies with EIM was higher among populations at a higher gastric cancer risk than in those with a lower cancer risk. EIM was mostly associated with IC rather than DC or with miscellaneous gastric diseases (841 control gastrectomies) in both basins. The proportion of gastrectomies with EIM was significantly higher in Vancouver than in New York and in Santiago de Chile than in Buenos Aires, even though these populations reside at approximately the same geographical latitude, but in different basins. Environmental factors seem to accelerate the evolution of EIM.en
dc.language.isoenen
dc.publisherBMJ Pub. Groupen
dc.relation.urlhttp://jcp.bmjjournals.com/cgi/reprint/58/12/1271en
dc.subjectAge Factorsen
dc.subjectAgeden
dc.subjectAtlantic Oceanen
dc.subjectGastrectomyen
dc.subjectGastric Mucosaen
dc.subjectMetaplasiaen
dc.subjectMiddle Ageden
dc.subjectPacific Oceanen
dc.subjectPhenotypeen
dc.subjectPrecancerous Conditionsen
dc.subjectStomach Diseasesen
dc.subjectStomach Neoplasmsen
dc.titleExtensive intestinal metaplasia in gastric carcinoma and in other lesions requiring surgery: a study of 3,421 gastrectomy specimens from dwellers of the Atlantic and Pacific basinsen
dc.typeArticleen
dc.identifier.journalJournal of clinical pathologyen
dc.format.digYES-

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