Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults

2.50
Hdl Handle:
http://hdl.handle.net/2336/29503
Title:
Beneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adults
Authors:
Ramel, A; Martinéz, A; Kiely, M; Morais, G; Bandarra, NM; Thorsdottir, I
Citation:
Diabetologia. 2008, 51(7):1261-68
Issue Date:
1-Jul-2008
Abstract:
AIMS/HYPOTHESIS: Epidemiological research indicates that long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) improve insulin resistance. The aim of this study was to investigate the effects of seafood consumption on insulin resistance in overweight participants during energy restriction. METHODS: In this 8 week dietary intervention, 324 participants (20-40 years, BMI 27.5-32.5 kg/m(2), from Iceland, Spain and Ireland) were randomised by computer to one of four energy-restricted diets (-30E%) of identical macronutrient composition but different LC n-3 PUFA content: control (n = 80; no seafood; single-blinded); lean fish (n = 80; 150 g cod, three times/week); fatty fish (n = 84; 150 g salmon, three times/week); (4) fish oil (n = 80; daily docosahexaenoic/eicosapentaenoic acid capsules, no other seafood; single-blinded). Fasting glucose, insulin, adiponectin, plasma triacylglycerol and fatty acids in erythrocyte membrane were measured at baseline and endpoint. Insulin resistance was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR). Linear models with fixed effects and covariates were used to investigate the effects of seafood consumption on fasting insulin and HOMA-IR at endpoint in comparison with the control group. RESULTS: Of the participants, 278 (86%) completed the intervention. Fish oil intake was a significant predictor of fasting insulin and insulin resistance after 8 weeks, and this finding remained significant even after including weight loss, triacylglycerol reduction, increased LC n-3 PUFA in membranes or adiponectin changes as covariates in the statistical analysis. Weight loss was also a significant predictor of improvements. CONCLUSIONS/INTERPRETATION: LC n-3 PUFA consumption during energy reduction exerts positive effects on insulin resistance in young overweight individuals, independently from changes in body weight, triacylglycerol, erythrocyte membrane or adiponectin. Trial registration: ClinicalTrials.gov NCT00315770. Funding: The YOUNG study is part of the SEAFOODplus Integrated Project, which is funded by the EC through the 6th Framework Programme Contract No. FOOD-CT-2004-506359.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
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Full metadata record

DC FieldValue Language
dc.contributor.authorRamel, A-
dc.contributor.authorMartinéz, A-
dc.contributor.authorKiely, M-
dc.contributor.authorMorais, G-
dc.contributor.authorBandarra, NM-
dc.contributor.authorThorsdottir, I-
dc.date.accessioned2008-06-04T12:36:31Z-
dc.date.available2008-06-04T12:36:31Z-
dc.date.issued2008-07-01-
dc.date.submitted2008-06-04-
dc.identifier.citationDiabetologia. 2008, 51(7):1261-68en
dc.identifier.issn0012-186X-
dc.identifier.pmid18491071-
dc.identifier.doi10.1007/s00125-008-1035-7-
dc.identifier.urihttp://hdl.handle.net/2336/29503-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractAIMS/HYPOTHESIS: Epidemiological research indicates that long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) improve insulin resistance. The aim of this study was to investigate the effects of seafood consumption on insulin resistance in overweight participants during energy restriction. METHODS: In this 8 week dietary intervention, 324 participants (20-40 years, BMI 27.5-32.5 kg/m(2), from Iceland, Spain and Ireland) were randomised by computer to one of four energy-restricted diets (-30E%) of identical macronutrient composition but different LC n-3 PUFA content: control (n = 80; no seafood; single-blinded); lean fish (n = 80; 150 g cod, three times/week); fatty fish (n = 84; 150 g salmon, three times/week); (4) fish oil (n = 80; daily docosahexaenoic/eicosapentaenoic acid capsules, no other seafood; single-blinded). Fasting glucose, insulin, adiponectin, plasma triacylglycerol and fatty acids in erythrocyte membrane were measured at baseline and endpoint. Insulin resistance was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR). Linear models with fixed effects and covariates were used to investigate the effects of seafood consumption on fasting insulin and HOMA-IR at endpoint in comparison with the control group. RESULTS: Of the participants, 278 (86%) completed the intervention. Fish oil intake was a significant predictor of fasting insulin and insulin resistance after 8 weeks, and this finding remained significant even after including weight loss, triacylglycerol reduction, increased LC n-3 PUFA in membranes or adiponectin changes as covariates in the statistical analysis. Weight loss was also a significant predictor of improvements. CONCLUSIONS/INTERPRETATION: LC n-3 PUFA consumption during energy reduction exerts positive effects on insulin resistance in young overweight individuals, independently from changes in body weight, triacylglycerol, erythrocyte membrane or adiponectin. Trial registration: ClinicalTrials.gov NCT00315770. Funding: The YOUNG study is part of the SEAFOODplus Integrated Project, which is funded by the EC through the 6th Framework Programme Contract No. FOOD-CT-2004-506359.en
dc.languageENG-
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.relation.urlhttp://www.springerlink.com/content/c0062871xx1v4272en
dc.subject.meshFatty Acids, Omega-3en
dc.subject.meshInsulin Resistanceen
dc.subject.meshWeight Lossen
dc.subject.meshDieten
dc.subject.meshDiet, Reducingen
dc.titleBeneficial effects of long-chain n-3 fatty acids included in an energy-restricted diet on insulin resistance in overweight and obese European young adultsen
dc.typeArticleen
dc.contributor.departmentUnit for Nutrition Research, Landspitali-University Hospital & Faculty of Food Science and Nutrition, Eiriksgata 29, 101, Reykjavik, Iceland.en
dc.identifier.journalDiabetologiaen

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