Differences in the glomerular filtration rate calculated by two creatinine-based and three cystatin-C-based formulae in hospitalized elderly patients

2.50
Hdl Handle:
http://hdl.handle.net/2336/29542
Title:
Differences in the glomerular filtration rate calculated by two creatinine-based and three cystatin-C-based formulae in hospitalized elderly patients
Authors:
Ramel, Alfons; Jonsson, Palmi V; Bjornsson, Sigurbjorn; Thorsdottir, Inga
Citation:
Nephron Clin Pract. 2008, 108(1):c16-22
Issue Date:
1-Feb-2008
Abstract:
BACKGROUND: Reduced renal function is a health problem in elderly patients. Different creatinine- and cystatin-C-based formulae have been used to estimate glomerular filtration rate (GFR). AIMS: To investigate individual and group differences of GFR estimates derived from five different formulae. METHODS: 60 patients were randomly assigned to participate in this cross-sectional study. Nutrition status was assessed, blood samples were drawn and GFR was calculated using two creatinine- and three cystatin-C-based formulae. RESULTS: Four of five formulae indicate reduced GFR in >70% of the participants, GFR was significantly less in malnourished patients according to one creatinine formula. Estimates from the formulae were highly correlated (r = 0.607-0.863, p < 0.001), but individual differences were between -36.1 and 79.9 ml/min/1.73 m(2). The formulae grouped 38.3-60.0% of the subjects differently into the five stages of chronic kidney disease. BMI, total cholesterol, age and gender were significant predictors for the calculated GFR differences between the formulae. CONCLUSION: The prevalence of reduced renal function is high in elderly hospitalized patients. BMI, age and/or gender can affect GFR estimates depending on the formula used, and there is an association between total cholesterol and calculated GFR differences between formulae. Different formulae can result in a different grouping of patients into the five stages of chronic renal disease.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1159/000112477

Full metadata record

DC FieldValue Language
dc.contributor.authorRamel, Alfons-
dc.contributor.authorJonsson, Palmi V-
dc.contributor.authorBjornsson, Sigurbjorn-
dc.contributor.authorThorsdottir, Inga-
dc.date.accessioned2008-06-04T15:03:21Z-
dc.date.available2008-06-04T15:03:21Z-
dc.date.issued2008-02-01-
dc.date.submitted2008-06-04-
dc.identifier.citationNephron Clin Pract. 2008, 108(1):c16-22en
dc.identifier.issn1660-8151-
dc.identifier.pmid18075276-
dc.identifier.doi10.1159/000112477-
dc.identifier.urihttp://hdl.handle.net/2336/29542-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: Reduced renal function is a health problem in elderly patients. Different creatinine- and cystatin-C-based formulae have been used to estimate glomerular filtration rate (GFR). AIMS: To investigate individual and group differences of GFR estimates derived from five different formulae. METHODS: 60 patients were randomly assigned to participate in this cross-sectional study. Nutrition status was assessed, blood samples were drawn and GFR was calculated using two creatinine- and three cystatin-C-based formulae. RESULTS: Four of five formulae indicate reduced GFR in >70% of the participants, GFR was significantly less in malnourished patients according to one creatinine formula. Estimates from the formulae were highly correlated (r = 0.607-0.863, p < 0.001), but individual differences were between -36.1 and 79.9 ml/min/1.73 m(2). The formulae grouped 38.3-60.0% of the subjects differently into the five stages of chronic kidney disease. BMI, total cholesterol, age and gender were significant predictors for the calculated GFR differences between the formulae. CONCLUSION: The prevalence of reduced renal function is high in elderly hospitalized patients. BMI, age and/or gender can affect GFR estimates depending on the formula used, and there is an association between total cholesterol and calculated GFR differences between formulae. Different formulae can result in a different grouping of patients into the five stages of chronic renal disease.en
dc.language.isoenen
dc.publisherKargeren
dc.relation.urlhttp://dx.doi.org/10.1159/000112477en
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshCreatinineen
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshCystatinsen
dc.subject.meshFemaleen
dc.subject.meshGlomerular Filtration Rateen
dc.subject.meshHospitalizationen
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshRandom Allocationen
dc.titleDifferences in the glomerular filtration rate calculated by two creatinine-based and three cystatin-C-based formulae in hospitalized elderly patientsen
dc.typeArticleen
dc.identifier.eissn1660-2110-
dc.contributor.departmentUnit for Nutrition Research, Landspitali-University Hospital and Department of Food Science and Human Nutrition, University of Iceland, Reykjavik, Iceland. alfons@landspitali.isen
dc.identifier.journalNephron. Clinical practiceen
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