A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

2.50
Hdl Handle:
http://hdl.handle.net/2336/29563
Title:
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
Authors:
Thorgeirsson, Thorgeir E; Geller, Frank; Sulem, Patrick; Rafnar, Thorunn; Wiste, Anna; Magnusson, Kristinn P; Manolescu, Andrei; Thorleifsson, Gudmar; Stefansson, Hreinn; Ingason, Andres; Stacey, Simon N; Bergthorsson, Jon T; Thorlacius, Steinunn; Gudmundsson, Julius; Jonsson, Thorlakur; Jakobsdottir, Margret; Saemundsdottir, Jona; Olafsdottir, Olof; Gudmundsson, Larus J; Bjornsdottir, Gyda; Kristjansson, Kristleifur; Skuladottir, Halla; Isaksson, Helgi J; Gudbjartsson, Tomas; Jones, Gregory T; Mueller, Thomas; Gottsäter, Anders; Flex, Andrea; Aben, Katja K H; de Vegt, Femmie; Mulders, Peter F A; Isla, Dolores; Vidal, Maria J; Asin, Laura; Saez, Berta; Murillo, Laura; Blondal, Thorsteinn; Kolbeinsson, Halldor; Stefansson, Jon G; Hansdottir, Ingunn; Runarsdottir, Valgerdur; Pola, Roberto; Lindblad, Bengt; van Rij, Andre M; Dieplinger, Benjamin; Haltmayer, Meinhard; Mayordomo, Jose I; Kiemeney, Lambertus A; Matthiasson, Stefan E; Oskarsson, Hogni; Tyrfingsson, Thorarinn; Gudbjartsson, Daniel F; Gulcher, Jeffrey R; Jonsson, Steinn; Thorsteinsdottir, Unnur; Kong, Augustine; Stefansson, Kari
Citation:
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. 2008, 452 (7187):638-42 Nature
Issue Date:
3-Apr-2008
Abstract:
Smoking is a leading cause of preventable death, causing about 5 million premature deaths worldwide each year. Evidence for genetic influence on smoking behaviour and nicotine dependence (ND) has prompted a search for susceptibility genes. Furthermore, assessing the impact of sequence variants on smoking-related diseases is important to public health. Smoking is the major risk factor for lung cancer (LC) and is one of the main risk factors for peripheral arterial disease (PAD). Here we identify a common variant in the nicotinic acetylcholine receptor gene cluster on chromosome 15q24 with an effect on smoking quantity, ND and the risk of two smoking-related diseases in populations of European descent. The variant has an effect on the number of cigarettes smoked per day in our sample of smokers. The same variant was associated with ND in a previous genome-wide association study that used low-quantity smokers as controls, and with a similar approach we observe a highly significant association with ND. A comparison of cases of LC and PAD with population controls each showed that the variant confers risk of LC and PAD. The findings provide a case study of a gene-environment interaction, highlighting the role of nicotine addiction in the pathology of other serious diseases.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1038/nature06846

Full metadata record

DC FieldValue Language
dc.contributor.authorThorgeirsson, Thorgeir E-
dc.contributor.authorGeller, Frank-
dc.contributor.authorSulem, Patrick-
dc.contributor.authorRafnar, Thorunn-
dc.contributor.authorWiste, Anna-
dc.contributor.authorMagnusson, Kristinn P-
dc.contributor.authorManolescu, Andrei-
dc.contributor.authorThorleifsson, Gudmar-
dc.contributor.authorStefansson, Hreinn-
dc.contributor.authorIngason, Andres-
dc.contributor.authorStacey, Simon N-
dc.contributor.authorBergthorsson, Jon T-
dc.contributor.authorThorlacius, Steinunn-
dc.contributor.authorGudmundsson, Julius-
dc.contributor.authorJonsson, Thorlakur-
dc.contributor.authorJakobsdottir, Margret-
dc.contributor.authorSaemundsdottir, Jona-
dc.contributor.authorOlafsdottir, Olof-
dc.contributor.authorGudmundsson, Larus J-
dc.contributor.authorBjornsdottir, Gyda-
dc.contributor.authorKristjansson, Kristleifur-
dc.contributor.authorSkuladottir, Halla-
dc.contributor.authorIsaksson, Helgi J-
dc.contributor.authorGudbjartsson, Tomas-
dc.contributor.authorJones, Gregory T-
dc.contributor.authorMueller, Thomas-
dc.contributor.authorGottsäter, Anders-
dc.contributor.authorFlex, Andrea-
dc.contributor.authorAben, Katja K H-
dc.contributor.authorde Vegt, Femmie-
dc.contributor.authorMulders, Peter F A-
dc.contributor.authorIsla, Dolores-
dc.contributor.authorVidal, Maria J-
dc.contributor.authorAsin, Laura-
dc.contributor.authorSaez, Berta-
dc.contributor.authorMurillo, Laura-
dc.contributor.authorBlondal, Thorsteinn-
dc.contributor.authorKolbeinsson, Halldor-
dc.contributor.authorStefansson, Jon G-
dc.contributor.authorHansdottir, Ingunn-
dc.contributor.authorRunarsdottir, Valgerdur-
dc.contributor.authorPola, Roberto-
dc.contributor.authorLindblad, Bengt-
dc.contributor.authorvan Rij, Andre M-
dc.contributor.authorDieplinger, Benjamin-
dc.contributor.authorHaltmayer, Meinhard-
dc.contributor.authorMayordomo, Jose I-
dc.contributor.authorKiemeney, Lambertus A-
dc.contributor.authorMatthiasson, Stefan E-
dc.contributor.authorOskarsson, Hogni-
dc.contributor.authorTyrfingsson, Thorarinn-
dc.contributor.authorGudbjartsson, Daniel F-
dc.contributor.authorGulcher, Jeffrey R-
dc.contributor.authorJonsson, Steinn-
dc.contributor.authorThorsteinsdottir, Unnur-
dc.contributor.authorKong, Augustine-
dc.contributor.authorStefansson, Kari-
dc.date.accessioned2008-06-05T16:00:55Z-
dc.date.available2008-06-05T16:00:55Z-
dc.date.issued2008-04-03-
dc.date.submitted2008-06-05-
dc.identifier.citationA variant associated with nicotine dependence, lung cancer and peripheral arterial disease. 2008, 452 (7187):638-42 Natureen
dc.identifier.issn0028-0836-
dc.identifier.pmid18385739-
dc.identifier.doi10.1038/nature06846-
dc.identifier.urihttp://hdl.handle.net/2336/29563-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractSmoking is a leading cause of preventable death, causing about 5 million premature deaths worldwide each year. Evidence for genetic influence on smoking behaviour and nicotine dependence (ND) has prompted a search for susceptibility genes. Furthermore, assessing the impact of sequence variants on smoking-related diseases is important to public health. Smoking is the major risk factor for lung cancer (LC) and is one of the main risk factors for peripheral arterial disease (PAD). Here we identify a common variant in the nicotinic acetylcholine receptor gene cluster on chromosome 15q24 with an effect on smoking quantity, ND and the risk of two smoking-related diseases in populations of European descent. The variant has an effect on the number of cigarettes smoked per day in our sample of smokers. The same variant was associated with ND in a previous genome-wide association study that used low-quantity smokers as controls, and with a similar approach we observe a highly significant association with ND. A comparison of cases of LC and PAD with population controls each showed that the variant confers risk of LC and PAD. The findings provide a case study of a gene-environment interaction, highlighting the role of nicotine addiction in the pathology of other serious diseases.en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.urlhttp://dx.doi.org/10.1038/nature06846en
dc.subject.meshChromosomes, Human, Pair 15en
dc.subject.meshEuropeen
dc.subject.meshFemaleen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshGenotypeen
dc.subject.meshHumansen
dc.subject.meshLung Neoplasmsen
dc.subject.meshMaleen
dc.subject.meshMultigene Familyen
dc.subject.meshNew Zealanden
dc.subject.meshOdds Ratioen
dc.subject.meshPeripheral Vascular Diseasesen
dc.subject.meshPolymorphism, Single Nucleotideen
dc.subject.meshReceptors, Nicotinicen
dc.subject.meshSmokingen
dc.subject.meshTobacco Use Disorderen
dc.titleA variant associated with nicotine dependence, lung cancer and peripheral arterial diseaseen
dc.typeArticleen
dc.identifier.eissn1476-4687-
dc.identifier.journalNatureen

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