Influence of moderate energy restriction and seafood consumption on bone turnover in overweight young adults

2.50
Hdl Handle:
http://hdl.handle.net/2336/29597
Title:
Influence of moderate energy restriction and seafood consumption on bone turnover in overweight young adults
Authors:
Lucey, Alice J; Paschos, George K; Cashman, Kevin D; Martínéz, J Alfredo; Thorsdottir, Inga; Kiely, Máiread
Citation:
Am. J. Clin. Nutr. 2008, 87(4):1045-52
Issue Date:
1-Apr-2008
Abstract:
BACKGROUND: Overweight and obesity are increasing in young adults. However, moderate energy restriction aimed at lowering body weight may promote bone turnover and bone loss. Inclusion of fish or fish oils in a weight-loss diet may attenuate these adverse skeletal effects. OBJECTIVE: We examined the effects of incorporating fish or fish oil into an energy-restricted diet on bone turnover markers in young overweight adults. DESIGN: While following a strict hypoenergetic (-30% relative to estimated requirements) diet for 8 wk, 276 overweight men and women [body mass index (in kg/m(2)): 27.5-32.5; age: 20-40 y) were randomly assigned to 1 of 4 dietary groups: sunflower-oil capsules (3 g/d; control), cod (3 x 150 g/wk), salmon (3 x 150 g/wk), and fish-oil capsules (3 g/d). Body weight, bone biomarkers, and 25-hydroxyvitamin D were measured at baseline and endpoint. Data were analyzed with repeated-measures analysis of variance and general linear models. RESULTS: The mean (+/-SD) weight loss was 5.14 +/- 3.0 kg (5.8% +/- 3.2% body weight) during the 8 wk in the 4 dietary groups combined. Urinary N-telopeptides of type I collagen and serum C-terminal telopeptide of type I collagen increased (P < 0.05), whereas serum osteocalcin (but not bone-specific alkaline phosphatase) decreased (P < 0.05) from baseline to endpoint. Increased fish or fish-oil consumption had no effect (P > 0.1) on the changes in bone markers induced by weight loss. In contrast, increased salmon consumption increased serum 25-hydroxyvitamin D (P < 0.01). CONCLUSIONS: A nutritionally adequate but energy-restricted diet, with different contents of n-3 fatty acids, which resulted in modest weight loss, unfavorably altered bone turnover markers in young overweight adults. Such changes were not prevented by increased fish or fish-oil consumption.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.ajcn.org/cgi/content/abstract/87/4/1045

Full metadata record

DC FieldValue Language
dc.contributor.authorLucey, Alice J-
dc.contributor.authorPaschos, George K-
dc.contributor.authorCashman, Kevin D-
dc.contributor.authorMartínéz, J Alfredo-
dc.contributor.authorThorsdottir, Inga-
dc.contributor.authorKiely, Máiread-
dc.date.accessioned2008-06-06T12:01:13Z-
dc.date.available2008-06-06T12:01:13Z-
dc.date.issued2008-04-01-
dc.date.submitted2008-06-06-
dc.identifier.citationAm. J. Clin. Nutr. 2008, 87(4):1045-52en
dc.identifier.issn0002-9165-
dc.identifier.pmid18400730-
dc.identifier.urihttp://hdl.handle.net/2336/29597-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: Overweight and obesity are increasing in young adults. However, moderate energy restriction aimed at lowering body weight may promote bone turnover and bone loss. Inclusion of fish or fish oils in a weight-loss diet may attenuate these adverse skeletal effects. OBJECTIVE: We examined the effects of incorporating fish or fish oil into an energy-restricted diet on bone turnover markers in young overweight adults. DESIGN: While following a strict hypoenergetic (-30% relative to estimated requirements) diet for 8 wk, 276 overweight men and women [body mass index (in kg/m(2)): 27.5-32.5; age: 20-40 y) were randomly assigned to 1 of 4 dietary groups: sunflower-oil capsules (3 g/d; control), cod (3 x 150 g/wk), salmon (3 x 150 g/wk), and fish-oil capsules (3 g/d). Body weight, bone biomarkers, and 25-hydroxyvitamin D were measured at baseline and endpoint. Data were analyzed with repeated-measures analysis of variance and general linear models. RESULTS: The mean (+/-SD) weight loss was 5.14 +/- 3.0 kg (5.8% +/- 3.2% body weight) during the 8 wk in the 4 dietary groups combined. Urinary N-telopeptides of type I collagen and serum C-terminal telopeptide of type I collagen increased (P < 0.05), whereas serum osteocalcin (but not bone-specific alkaline phosphatase) decreased (P < 0.05) from baseline to endpoint. Increased fish or fish-oil consumption had no effect (P > 0.1) on the changes in bone markers induced by weight loss. In contrast, increased salmon consumption increased serum 25-hydroxyvitamin D (P < 0.01). CONCLUSIONS: A nutritionally adequate but energy-restricted diet, with different contents of n-3 fatty acids, which resulted in modest weight loss, unfavorably altered bone turnover markers in young overweight adults. Such changes were not prevented by increased fish or fish-oil consumption.en
dc.language.isoenen
dc.publisherAmerican Society of Clinical Nutritionen
dc.relation.urlhttp://www.ajcn.org/cgi/content/abstract/87/4/1045en
dc.subject.meshAdulten
dc.subject.meshAnalysis of Varianceen
dc.subject.meshAnimalsen
dc.subject.meshBiological Markersen
dc.subject.meshBody Mass Indexen
dc.subject.meshBone Resorptionen
dc.subject.meshBone and Bonesen
dc.subject.meshDiet, Reducingen
dc.subject.meshDietary Supplementsen
dc.subject.meshFemaleen
dc.subject.meshFish Oilsen
dc.subject.meshGadiformesen
dc.subject.meshHumansen
dc.subject.meshLinear Modelsen
dc.subject.meshMaleen
dc.subject.meshOsteocalcinen
dc.subject.meshOverweighten
dc.subject.meshPlant Oilsen
dc.subject.meshSalmonen
dc.subject.meshSeafooden
dc.subject.meshTreatment Outcomeen
dc.subject.meshVitamin Den
dc.subject.meshWeight Lossen
dc.titleInfluence of moderate energy restriction and seafood consumption on bone turnover in overweight young adultsen
dc.typeArticleen
dc.identifier.journalAmerican journal of clinical nutritionen

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