Evaluating iodine deficiency in pregnant women and young infants-complex physiology with a risk of misinterpretation.

2.50
Hdl Handle:
http://hdl.handle.net/2336/29959
Title:
Evaluating iodine deficiency in pregnant women and young infants-complex physiology with a risk of misinterpretation.
Authors:
Laurberg, P; Andersen, S; Bjarnadóttir, R I; Carlé, A; Hreidarsson, Ab; Knudsen, N; Ovesen, L; Pedersen, Ib; Rasmussen, Lb
Citation:
Public Health Nutr. 2007, 10(12A):1547-52; discussion 1553
Issue Date:
1-Dec-2007
Abstract:
OBJECTIVE: To review methods for evaluating iodine deficiency in pregnant women and young infants and to discuss factors to be considered in the interpretation of their results. DESIGN: Review of the literature regarding the various methods available for assessing iodine status.Setting: Population surveys and research studies. SUBJECTS: Pregnant women and young infants. RESULTS: Several factors to consider when assessing iodine status in pregnant women and young infants include: 1) the urinary iodine (UI) concentration (microg l-1) is not interchangeable with 24 h UI excretion (microg per 24 h); 2) the concentration of iodine in a spot or casual urine sample cannot be used to diagnose iodine deficiency in an individual; 3) a moderate fall in the concentration of serum free T4 during pregnancy is not a sign of maternal iodine deficiency; 4) an increase in the concentration of serum thyroglobulin (Tg) during pregnancy is not a sign of maternal iodine deficiency; 5) a higher concentration of TSH and Tg in cord blood than in maternal blood is not a sign of iodine deficiency in the mother or neonate; and 6) thyroid function in a full-term foetus, a neonate or a small child is not more sensitive to a mild iodine deficiency than in the mother. CONCLUSIONS: If the iodine status of pregnant women and small children is not to be misjudged, the above six factors need to be taken into account.
Description:
To access publisher full version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1017/S1368980007360898

Full metadata record

DC FieldValue Language
dc.contributor.authorLaurberg, P-
dc.contributor.authorAndersen, S-
dc.contributor.authorBjarnadóttir, R I-
dc.contributor.authorCarlé, A-
dc.contributor.authorHreidarsson, Ab-
dc.contributor.authorKnudsen, N-
dc.contributor.authorOvesen, L-
dc.contributor.authorPedersen, Ib-
dc.contributor.authorRasmussen, Lb-
dc.date.accessioned2008-06-12T11:49:56Z-
dc.date.available2008-06-12T11:49:56Z-
dc.date.issued2007-12-01-
dc.date.submitted2008-06-12-
dc.identifier.citationPublic Health Nutr. 2007, 10(12A):1547-52; discussion 1553en
dc.identifier.issn1368-9800-
dc.identifier.pmid18053278-
dc.identifier.doi10.1017/S1368980007360898-
dc.identifier.urihttp://hdl.handle.net/2336/29959-
dc.descriptionTo access publisher full version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVE: To review methods for evaluating iodine deficiency in pregnant women and young infants and to discuss factors to be considered in the interpretation of their results. DESIGN: Review of the literature regarding the various methods available for assessing iodine status.Setting: Population surveys and research studies. SUBJECTS: Pregnant women and young infants. RESULTS: Several factors to consider when assessing iodine status in pregnant women and young infants include: 1) the urinary iodine (UI) concentration (microg l-1) is not interchangeable with 24 h UI excretion (microg per 24 h); 2) the concentration of iodine in a spot or casual urine sample cannot be used to diagnose iodine deficiency in an individual; 3) a moderate fall in the concentration of serum free T4 during pregnancy is not a sign of maternal iodine deficiency; 4) an increase in the concentration of serum thyroglobulin (Tg) during pregnancy is not a sign of maternal iodine deficiency; 5) a higher concentration of TSH and Tg in cord blood than in maternal blood is not a sign of iodine deficiency in the mother or neonate; and 6) thyroid function in a full-term foetus, a neonate or a small child is not more sensitive to a mild iodine deficiency than in the mother. CONCLUSIONS: If the iodine status of pregnant women and small children is not to be misjudged, the above six factors need to be taken into account.en
dc.language.isoenen
dc.publisherPublished on behalf of the Nutrition Society by CAB Internationalen
dc.relation.urlhttp://dx.doi.org/10.1017/S1368980007360898en
dc.subject.meshAdulten
dc.subject.meshFemaleen
dc.subject.meshFetal Blooden
dc.subject.meshHumansen
dc.subject.meshInfanten
dc.subject.meshInfant, Newbornen
dc.subject.meshIodineen
dc.subject.meshMaleen
dc.subject.meshNutrition Assessmenten
dc.subject.meshNutritional Statusen
dc.subject.meshPregnancyen
dc.subject.meshPregnancy Complicationsen
dc.subject.meshSensitivity and Specificityen
dc.subject.meshThyroid Glanden
dc.subject.meshThyrotropinen
dc.subject.meshThyroxineen
dc.subject.meshTriiodothyronineen
dc.titleEvaluating iodine deficiency in pregnant women and young infants-complex physiology with a risk of misinterpretation.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Aalborg Hospital, Aalborg, Denmark. laurberg@aas.nja.dken
dc.identifier.journalPublic health nutritionen

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