Relationship between size at birth and hypertension in a genetically homogeneous population of high birth weight

2.50
Hdl Handle:
http://hdl.handle.net/2336/30494
Title:
Relationship between size at birth and hypertension in a genetically homogeneous population of high birth weight
Authors:
Gunnarsdottir, Ingibjorg; Birgisdottir, Bryndis E; Benediktsson, Rafn; Gudnason, Vilmundur; Thorsdottir, Inga
Citation:
J. Hypertens. 2002, 20(4):623-8
Issue Date:
1-Apr-2002
Abstract:
OBJECTIVE: To investigate the association between birth size and hypertension within a genetically homogeneous population of high birth weight. DESIGN: Cohort-study with retrospectively collected data on size at birth. SUBJECTS AND SETTING: The study included 4601 men and women born 1914-1935 in Reykjavik, Iceland, who participated in the Reykjavik Study of the Icelandic Heart Association. MAIN OUTCOME MEASURES: Birth size measurements, adult blood pressure (BP) and body mass index (BMI), and family history of hypertension. RESULTS: Birth weight was inversely related to hypertension in adulthood in women (P for trend < 0.001). The relationship was of borderline significance in men (P for trend = 0.051). A low ponderal index was significantly associated with high BP in women (P for trend = 0.025) but not men (P > 0.05). For women with an adult BMI > 26 kg/m2, the odds ratio for hypertension for those born weighing < 3.45 kg was 2.1 [95% confidence interval, 1.3-3.3, compared with women born weighing > 3.75 kg. The association was only significant in women without a family history of hypertension. CONCLUSIONS: An inverse association between size at birth and adult hypertension was seen in a population of greater birth size than has previously been investigated. The relation was strongest among women born small who were overweight in adulthood, and for those without a family history of hypertension. The results support the hypothesis that the association between birth weight and hypertension is not of genetic origin only. The large birth size of Icelanders might be protective and partly explain the lower mean systolic blood pressure in Iceland than in related nations.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
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Full metadata record

DC FieldValue Language
dc.contributor.authorGunnarsdottir, Ingibjorg-
dc.contributor.authorBirgisdottir, Bryndis E-
dc.contributor.authorBenediktsson, Rafn-
dc.contributor.authorGudnason, Vilmundur-
dc.contributor.authorThorsdottir, Inga-
dc.date.accessioned2008-06-26T14:18:10Z-
dc.date.available2008-06-26T14:18:10Z-
dc.date.issued2002-04-01-
dc.date.submitted2008-06-26-
dc.identifier.citationJ. Hypertens. 2002, 20(4):623-8en
dc.identifier.issn0263-6352-
dc.identifier.pmid11910296-
dc.identifier.urihttp://hdl.handle.net/2336/30494-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVE: To investigate the association between birth size and hypertension within a genetically homogeneous population of high birth weight. DESIGN: Cohort-study with retrospectively collected data on size at birth. SUBJECTS AND SETTING: The study included 4601 men and women born 1914-1935 in Reykjavik, Iceland, who participated in the Reykjavik Study of the Icelandic Heart Association. MAIN OUTCOME MEASURES: Birth size measurements, adult blood pressure (BP) and body mass index (BMI), and family history of hypertension. RESULTS: Birth weight was inversely related to hypertension in adulthood in women (P for trend < 0.001). The relationship was of borderline significance in men (P for trend = 0.051). A low ponderal index was significantly associated with high BP in women (P for trend = 0.025) but not men (P > 0.05). For women with an adult BMI > 26 kg/m2, the odds ratio for hypertension for those born weighing < 3.45 kg was 2.1 [95% confidence interval, 1.3-3.3, compared with women born weighing > 3.75 kg. The association was only significant in women without a family history of hypertension. CONCLUSIONS: An inverse association between size at birth and adult hypertension was seen in a population of greater birth size than has previously been investigated. The relation was strongest among women born small who were overweight in adulthood, and for those without a family history of hypertension. The results support the hypothesis that the association between birth weight and hypertension is not of genetic origin only. The large birth size of Icelanders might be protective and partly explain the lower mean systolic blood pressure in Iceland than in related nations.en
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen
dc.relation.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=N&PAGE=fulltext&AN=00004691-200407000-00001&LSLINK=80&D=ovften
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshBirth Weighten
dc.subject.meshBlood Pressureen
dc.subject.meshBody Mass Indexen
dc.subject.meshCohort Studiesen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshHypertensionen
dc.subject.meshIcelanden
dc.subject.meshInfant, Newbornen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshOdds Ratioen
dc.subject.meshRetrospective Studiesen
dc.subject.meshRisk Factorsen
dc.subject.meshSex Characteristicsen
dc.titleRelationship between size at birth and hypertension in a genetically homogeneous population of high birth weighten
dc.typeArticleen
dc.contributor.departmentUnit for Nutrition Research, Landspitali-University Hospital and Department of Food Science, University of Iceland, Reykjavik, Iceland. ingigun@landspitali.isen
dc.identifier.journalJournal of hypertensionen

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