2.50
Hdl Handle:
http://hdl.handle.net/2336/30572
Title:
The postdialytic rise in the plasma total homocysteine concentration is delayed.
Authors:
Arnadottir, Margret; Wingren, Kerstin; Hultberg, Björn; Hegbrant, Jörgen
Citation:
Blood Purif. 2002, 20(4):334-7
Issue Date:
2002
Abstract:
BACKGROUND/AIMS: The mechanism behind the uremic hyperhomocysteinemia has not been elucidated. Possibly, dialyzable uremic toxins play a role, e.g. as enzyme inhibitors. If so, the conditions for enzymatic removal would be expected to improve after dialysis. Therefore, we studied the postdialytic pattern of the plasma total homocysteine (tHcy) concentration. METHODS: We collected blood samples from 19 stable, vitamin-supplemented hemodialysis patients before and at 5, 60, as well as at 480 min after a dialysis session. The patients were studied after dialysis with a low-flux dialyzer (Polyflux 6L) and a high-flux dialyzer (Polyflux 14S). RESULTS: The mean predialytic plasma tHcy concentration was 13.3 micromol/l which is considerably lower than the concentrations observed in our previous studies. In all patients, the plasma tHcy concentration fell during treatment with both types of dialyzers (average decrease 28 +/- 7%, p < 0.0001, and 31 +/- 8%, p < 0.0001, respectively). No postdialytic change in the plasma tHcy concentration was observed at 60 min after low-flux dialysis, however, after high-flux dialysis, the plasma tHcy concentration was significantly lower at 60 min postdialysis than at 5 min (3 +/- 8%, p < 0.05). At 480 min after dialysis, a significant postdialytic increase in the plasma tHcy concentration was found (6 +/- 9%, p < 0.01, and 11 +/- 5%, p < 0.0001, respectively) both in the case of low-flux and high-flux treatment. CONCLUSION: In the postdialytic phase, we observed a short-lived stability in the plasma tHcy concentration, and in the case of high-flux dialysis, even a slight decrease in the plasma tHcy concentration. The results support the hypothesis that dialyzable substances interfere with homocysteine removal.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1159/000063100

Full metadata record

DC FieldValue Language
dc.contributor.authorArnadottir, Margret-
dc.contributor.authorWingren, Kerstin-
dc.contributor.authorHultberg, Björn-
dc.contributor.authorHegbrant, Jörgen-
dc.date.accessioned2008-06-27T10:14:38Z-
dc.date.available2008-06-27T10:14:38Z-
dc.date.issued2002-
dc.date.submitted2008-06-27-
dc.identifier.citationBlood Purif. 2002, 20(4):334-7en
dc.identifier.issn0253-5068-
dc.identifier.pmid12169841-
dc.identifier.doi10.1159/000063100-
dc.identifier.urihttp://hdl.handle.net/2336/30572-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND/AIMS: The mechanism behind the uremic hyperhomocysteinemia has not been elucidated. Possibly, dialyzable uremic toxins play a role, e.g. as enzyme inhibitors. If so, the conditions for enzymatic removal would be expected to improve after dialysis. Therefore, we studied the postdialytic pattern of the plasma total homocysteine (tHcy) concentration. METHODS: We collected blood samples from 19 stable, vitamin-supplemented hemodialysis patients before and at 5, 60, as well as at 480 min after a dialysis session. The patients were studied after dialysis with a low-flux dialyzer (Polyflux 6L) and a high-flux dialyzer (Polyflux 14S). RESULTS: The mean predialytic plasma tHcy concentration was 13.3 micromol/l which is considerably lower than the concentrations observed in our previous studies. In all patients, the plasma tHcy concentration fell during treatment with both types of dialyzers (average decrease 28 +/- 7%, p < 0.0001, and 31 +/- 8%, p < 0.0001, respectively). No postdialytic change in the plasma tHcy concentration was observed at 60 min after low-flux dialysis, however, after high-flux dialysis, the plasma tHcy concentration was significantly lower at 60 min postdialysis than at 5 min (3 +/- 8%, p < 0.05). At 480 min after dialysis, a significant postdialytic increase in the plasma tHcy concentration was found (6 +/- 9%, p < 0.01, and 11 +/- 5%, p < 0.0001, respectively) both in the case of low-flux and high-flux treatment. CONCLUSION: In the postdialytic phase, we observed a short-lived stability in the plasma tHcy concentration, and in the case of high-flux dialysis, even a slight decrease in the plasma tHcy concentration. The results support the hypothesis that dialyzable substances interfere with homocysteine removal.en
dc.language.isoenen
dc.publisherS. Kargeren
dc.relation.urlhttp://dx.doi.org/10.1159/000063100en
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshAmbulatory Careen
dc.subject.meshCreatinineen
dc.subject.meshFemaleen
dc.subject.meshHomocysteineen
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshRenal Dialysisen
dc.subject.meshRheologyen
dc.subject.meshTime Factorsen
dc.subject.meshVitaminsen
dc.titleThe postdialytic rise in the plasma total homocysteine concentration is delayed.en
dc.typeArticleen
dc.contributor.departmentDepartment of Medicine, Landspitali University Hospital Hringbraut, Reykjavik, Iceland. margreta@rsp.isen
dc.identifier.journalBlood purificationen

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