Prognostic factors of mycological cure following treatment of onychomycosis with oral antifungal agents

2.50
Hdl Handle:
http://hdl.handle.net/2336/30912
Title:
Prognostic factors of mycological cure following treatment of onychomycosis with oral antifungal agents
Authors:
Sigurgeirsson, B; Paul, C; Curran, D; Evans, E G V
Citation:
Br. J. Dermatol. 2002, 147(6):1241-3
Issue Date:
1-Dec-2002
Abstract:
BACKGROUND: There is considerable literature on the efficacy and safety of various drugs used in treating onychomycosis; however, little information is available regarding prognostic factors which may be associated with non-response to conventional treatment. OBJECTIVES: To identify parameters influencing mycological cure at 72 weeks following treatment of toenail onychomycosis with oral antifungal agents. METHODS: Univariate and multivariate logistic regression analysis from a randomized double-blind controlled trial including 496 patients with toenail onychomycosis caused by dermatophytes. RESULTS: Baseline parameters including patient's age, gender, weight, number of toenails involved, percentage of nail involvement, duration of infection, history of previous treatment were not associated with mycological cure. In the multivariate prognostic factor analysis based on factors assessed at week 12, positive mycological culture at 12 weeks [odds ratio (OR): 0.583; 95% confidence interval (CI): 0.370-0.918] was negatively associated with mycological cure at 72 weeks. Similarly, in the multivariate prognostic factor analysis based on factors assessed at week 24, positive direct microscopy at 24 weeks (OR: 0.373; 95% CI: 0.211-0.659) and mycological culture at 24 weeks (OR: 0.293; 95% CI: 0.168-0.513) were negatively associated with mycological cure at 72 weeks. CONCLUSIONS: Mycological culture at 12 and 24 weeks and direct microscopic examination at 24 weeks can help in early identification of patients failing to respond to conventional oral antifungal treatment.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1046/j.1365-2133.2002.05035.x

Full metadata record

DC FieldValue Language
dc.contributor.authorSigurgeirsson, B-
dc.contributor.authorPaul, C-
dc.contributor.authorCurran, D-
dc.contributor.authorEvans, E G V-
dc.date.accessioned2008-07-03T13:31:57Z-
dc.date.available2008-07-03T13:31:57Z-
dc.date.issued2002-12-01-
dc.date.submitted2008-07-03-
dc.identifier.citationBr. J. Dermatol. 2002, 147(6):1241-3en
dc.identifier.issn0007-0963-
dc.identifier.pmid12452877-
dc.identifier.doi10.1046/j.1365-2133.2002.05035.x-
dc.identifier.urihttp://hdl.handle.net/2336/30912-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: There is considerable literature on the efficacy and safety of various drugs used in treating onychomycosis; however, little information is available regarding prognostic factors which may be associated with non-response to conventional treatment. OBJECTIVES: To identify parameters influencing mycological cure at 72 weeks following treatment of toenail onychomycosis with oral antifungal agents. METHODS: Univariate and multivariate logistic regression analysis from a randomized double-blind controlled trial including 496 patients with toenail onychomycosis caused by dermatophytes. RESULTS: Baseline parameters including patient's age, gender, weight, number of toenails involved, percentage of nail involvement, duration of infection, history of previous treatment were not associated with mycological cure. In the multivariate prognostic factor analysis based on factors assessed at week 12, positive mycological culture at 12 weeks [odds ratio (OR): 0.583; 95% confidence interval (CI): 0.370-0.918] was negatively associated with mycological cure at 72 weeks. Similarly, in the multivariate prognostic factor analysis based on factors assessed at week 24, positive direct microscopy at 24 weeks (OR: 0.373; 95% CI: 0.211-0.659) and mycological culture at 24 weeks (OR: 0.293; 95% CI: 0.168-0.513) were negatively associated with mycological cure at 72 weeks. CONCLUSIONS: Mycological culture at 12 and 24 weeks and direct microscopic examination at 24 weeks can help in early identification of patients failing to respond to conventional oral antifungal treatment.en
dc.language.isoenen
dc.publisherBlackwell Scientific Publicationsen
dc.relation.urlhttp://dx.doi.org/10.1046/j.1365-2133.2002.05035.xen
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshAnalysis of Varianceen
dc.subject.meshAntifungal Agentsen
dc.subject.meshDouble-Blind Methoden
dc.subject.meshFemaleen
dc.subject.meshFollow-Up Studiesen
dc.subject.meshFoot Dermatosesen
dc.subject.meshHumansen
dc.subject.meshItraconazoleen
dc.subject.meshLogistic Modelsen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshOnychomycosisen
dc.subject.meshPrognosisen
dc.subject.meshTreatment Outcomeen
dc.titlePrognostic factors of mycological cure following treatment of onychomycosis with oral antifungal agentsen
dc.typeArticleen
dc.identifier.eissn1365-2133-
dc.contributor.departmentDepartment of Dermatology, University of Iceland and Landspitalinn, University Hospital, Reykjavik, Iceland. bsig@simnet.isen
dc.identifier.journalBritish journal of dermatologyen
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