Cancer as a complex phenotype: pattern of cancer distribution within and beyond the nuclear family

2.50
Hdl Handle:
http://hdl.handle.net/2336/3185
Title:
Cancer as a complex phenotype: pattern of cancer distribution within and beyond the nuclear family
Authors:
Amundadottir, Laufey T; Thorvaldsson, Sverrir; Gudbjartsson, Daniel F; Sulem, Patrick; Kristjansson, Kristleifur; Arnason, Sigurdur; Gulcher, Jeffrey R; Bjornsson, Johannes; Kong, Augustine; Thorsteinsdottir, Unnur; Stefansson, Kari
Citation:
PLoS Med. 2004, 1(3):e65
Issue Date:
2004
Abstract:
BACKGROUND: The contribution of low-penetrant susceptibility variants to cancer is not clear. With the aim of searching for genetic factors that contribute to cancer at one or more sites in the body, we have analyzed familial aggregation of cancer in extended families based on all cancer cases diagnosed in Iceland over almost half a century. METHODS AND FINDINGS: We have estimated risk ratios (RRs) of cancer for first- and up to fifth-degree relatives both within and between all types of cancers diagnosed in Iceland from 1955 to 2002 by linking patient information from the Icelandic Cancer Registry to an extensive genealogical database, containing all living Icelanders and most of their ancestors since the settlement of Iceland. We evaluated the significance of the familial clustering for each relationship separately, all relationships combined (first- to fifth-degree relatives) and for close (first- and second-degree) and distant (third- to fifth-degree) relatives. Most cancer sites demonstrate a significantly increased RR for the same cancer, beyond the nuclear family. Significantly increased familial clustering between different cancer sites is also documented in both close and distant relatives. Some of these associations have been suggested previously but others not. CONCLUSION: We conclude that genetic factors are involved in the etiology of many cancers and that these factors are in some cases shared by different cancer sites. However, a significantly increased RR conferred upon mates of patients with cancer at some sites indicates that shared environment or nonrandom mating for certain risk factors also play a role in the familial clustering of cancer. Our results indicate that cancer is a complex, often non-site-specific disease for which increased risk extends beyond the nuclear family.
Description:
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Additional Links:
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Full metadata record

DC FieldValue Language
dc.contributor.authorAmundadottir, Laufey T-
dc.contributor.authorThorvaldsson, Sverrir-
dc.contributor.authorGudbjartsson, Daniel F-
dc.contributor.authorSulem, Patrick-
dc.contributor.authorKristjansson, Kristleifur-
dc.contributor.authorArnason, Sigurdur-
dc.contributor.authorGulcher, Jeffrey R-
dc.contributor.authorBjornsson, Johannes-
dc.contributor.authorKong, Augustine-
dc.contributor.authorThorsteinsdottir, Unnur-
dc.contributor.authorStefansson, Kari-
dc.date.accessioned2006-06-27T14:20:00Z-
dc.date.available2006-06-27T14:20:00Z-
dc.date.issued2004-
dc.identifier.citationPLoS Med. 2004, 1(3):e65en
dc.identifier.issn1549-1676-
dc.identifier.pmid15630470-
dc.identifier.doi10.1371/journal.pmed.0010065-
dc.identifier.urihttp://hdl.handle.net/2336/3185-
dc.descriptionTo access full text version of this article. Please click on the hyperlink "Full Text" at the bottom of this pageen
dc.description.abstractBACKGROUND: The contribution of low-penetrant susceptibility variants to cancer is not clear. With the aim of searching for genetic factors that contribute to cancer at one or more sites in the body, we have analyzed familial aggregation of cancer in extended families based on all cancer cases diagnosed in Iceland over almost half a century. METHODS AND FINDINGS: We have estimated risk ratios (RRs) of cancer for first- and up to fifth-degree relatives both within and between all types of cancers diagnosed in Iceland from 1955 to 2002 by linking patient information from the Icelandic Cancer Registry to an extensive genealogical database, containing all living Icelanders and most of their ancestors since the settlement of Iceland. We evaluated the significance of the familial clustering for each relationship separately, all relationships combined (first- to fifth-degree relatives) and for close (first- and second-degree) and distant (third- to fifth-degree) relatives. Most cancer sites demonstrate a significantly increased RR for the same cancer, beyond the nuclear family. Significantly increased familial clustering between different cancer sites is also documented in both close and distant relatives. Some of these associations have been suggested previously but others not. CONCLUSION: We conclude that genetic factors are involved in the etiology of many cancers and that these factors are in some cases shared by different cancer sites. However, a significantly increased RR conferred upon mates of patients with cancer at some sites indicates that shared environment or nonrandom mating for certain risk factors also play a role in the familial clustering of cancer. Our results indicate that cancer is a complex, often non-site-specific disease for which increased risk extends beyond the nuclear family.en
dc.language.isoenen
dc.publisherPLoS Medicineen
dc.relation.urlhttp://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed&pubmedid=15630470en
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectEnvironmenten
dc.subjectFamily Healthen
dc.subjectFemaleen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectHumansen
dc.subjectIceland/epidemiologyen
dc.subjectInfanten
dc.subjectInfant, Newbornen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectModels, Theoreticalen
dc.subjectNeoplasmsen
dc.subjectNeoplasmsen
dc.subjectPedigreeen
dc.subjectPhenotypeen
dc.subjectRegistriesen
dc.subjectResearch Support, Non-U.S. Gov'ten
dc.subjectRisk Factorsen
dc.titleCancer as a complex phenotype: pattern of cancer distribution within and beyond the nuclear familyen
dc.typeArticleen
dc.format.digYES-

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