2.50
Hdl Handle:
http://hdl.handle.net/2336/32052
Title:
Linkage of essential hypertension to chromosome 18q
Authors:
Kristjansson, Kristleifur; Manolescu, Andrei; Kristinsson, Arni; Hardarson, Thordur; Knudsen, Helga; Ingason, Sigurdur; Thorleifsson, Gudmar; Frigge, Michael L; Kong, Augustine; Gulcher, Jeffrey R; Stefansson, Kari
Citation:
Hypertension. 2002, 39(6):1044-9
Issue Date:
1-Jun-2002
Abstract:
We performed a genomewide scan with 904 microsatellite markers using 120 extended Icelandic families with 490 hypertensive patients. The families were identified by cross-matching a list of hypertensive patients from the Hypertension Clinic of the University Hospital (Landspitalinn) in Iceland with a genealogy database of the entire Icelandic nation. After adding 5 markers, we found linkage to chromosome 18q with an allele-sharing LOD score of 4.60 (P=2.1x 10(-6)). These results provide evidence for a novel susceptibility gene for essential hypertension on chromosome 18q and show that it is possible to study the genetics of essential hypertension without stratifying by subphenotypes.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://hyper.ahajournals.org/cgi/content/abstract/39/6/1044

Full metadata record

DC FieldValue Language
dc.contributor.authorKristjansson, Kristleifur-
dc.contributor.authorManolescu, Andrei-
dc.contributor.authorKristinsson, Arni-
dc.contributor.authorHardarson, Thordur-
dc.contributor.authorKnudsen, Helga-
dc.contributor.authorIngason, Sigurdur-
dc.contributor.authorThorleifsson, Gudmar-
dc.contributor.authorFrigge, Michael L-
dc.contributor.authorKong, Augustine-
dc.contributor.authorGulcher, Jeffrey R-
dc.contributor.authorStefansson, Kari-
dc.date.accessioned2008-07-15T14:28:24Z-
dc.date.available2008-07-15T14:28:24Z-
dc.date.issued2002-06-01-
dc.date.submitted2008-07-15-
dc.identifier.citationHypertension. 2002, 39(6):1044-9en
dc.identifier.issn1524-4563-
dc.identifier.pmid12052839-
dc.identifier.urihttp://hdl.handle.net/2336/32052-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractWe performed a genomewide scan with 904 microsatellite markers using 120 extended Icelandic families with 490 hypertensive patients. The families were identified by cross-matching a list of hypertensive patients from the Hypertension Clinic of the University Hospital (Landspitalinn) in Iceland with a genealogy database of the entire Icelandic nation. After adding 5 markers, we found linkage to chromosome 18q with an allele-sharing LOD score of 4.60 (P=2.1x 10(-6)). These results provide evidence for a novel susceptibility gene for essential hypertension on chromosome 18q and show that it is possible to study the genetics of essential hypertension without stratifying by subphenotypes.en
dc.language.isoenen
dc.publisherAmerican Heart Associationen
dc.relation.urlhttp://hyper.ahajournals.org/cgi/content/abstract/39/6/1044en
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshChromosomes, Human, Pair 18en
dc.subject.meshFamily Healthen
dc.subject.meshFemaleen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshGenome, Humanen
dc.subject.meshHumansen
dc.subject.meshHypertensionen
dc.subject.meshIcelanden
dc.subject.meshLinkage (Genetics)en
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.titleLinkage of essential hypertension to chromosome 18qen
dc.typeArticleen
dc.contributor.departmentdeCODE genetics, Inc, Reykjavik, Iceland. kris@ decode.isen
dc.identifier.journalHypertensionen

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