2.50
Hdl Handle:
http://hdl.handle.net/2336/32412
Title:
A major susceptibility gene for asthma maps to chromosome 14q24
Authors:
Hakonarson, Hakon; Bjornsdottir, Unnur S; Halapi, Eva; Palsson, Snaebjorn; Adalsteinsdottir, Elva; Gislason, David; Finnbogason, Gudmundur; Gislason, Thorarinn; Kristjansson, Kristleifur; Arnason, Thor; Birkisson, Illugi; Frigge, Michael L; Kong, Augustine; Gulcher, Jeffrey R; Stefansson, Kari
Citation:
Am. J. Hum. Genet. 2002, 71(3):483-91
Issue Date:
1-Sep-2002
Abstract:
Asthma is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. Numerous loci and candidate genes have been reported to show linkage and association to asthma and atopy. Although some studies reporting these observations are compelling, no gene has been mapped that confers a sufficiently high risk of asthma to meet the stringent criteria for genomewide significance. Using 175 extended Icelandic families that included 596 patients with asthma, we performed a genomewide scan with 976 microsatellite markers. The families were identified by cross-matching a list of patients with asthma from the Department of Allergy/Pulmonary Medicine of the National University Hospital of Iceland with a genealogy database of the entire Icelandic nation. We detected linkage of asthma to chromosome 14q24, with an allele-sharing LOD score of 2.66. After we increased the marker density within the locus to an average of one microsatellite every 0.2 cM, the LOD score rose to 4.00. We designate this locus "asthma locus one" (AS1). Taken together, these results provide evidence of a novel susceptibility gene for asthma on chromosome 14q24.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=379187

Full metadata record

DC FieldValue Language
dc.contributor.authorHakonarson, Hakon-
dc.contributor.authorBjornsdottir, Unnur S-
dc.contributor.authorHalapi, Eva-
dc.contributor.authorPalsson, Snaebjorn-
dc.contributor.authorAdalsteinsdottir, Elva-
dc.contributor.authorGislason, David-
dc.contributor.authorFinnbogason, Gudmundur-
dc.contributor.authorGislason, Thorarinn-
dc.contributor.authorKristjansson, Kristleifur-
dc.contributor.authorArnason, Thor-
dc.contributor.authorBirkisson, Illugi-
dc.contributor.authorFrigge, Michael L-
dc.contributor.authorKong, Augustine-
dc.contributor.authorGulcher, Jeffrey R-
dc.contributor.authorStefansson, Kari-
dc.date.accessioned2008-07-18T09:49:21Z-
dc.date.available2008-07-18T09:49:21Z-
dc.date.issued2002-09-01-
dc.date.submitted2008-07-18-
dc.identifier.citationAm. J. Hum. Genet. 2002, 71(3):483-91en
dc.identifier.issn0002-9297-
dc.identifier.pmid12119603-
dc.identifier.doi10.1086/342205-
dc.identifier.urihttp://hdl.handle.net/2336/32412-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractAsthma is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. Numerous loci and candidate genes have been reported to show linkage and association to asthma and atopy. Although some studies reporting these observations are compelling, no gene has been mapped that confers a sufficiently high risk of asthma to meet the stringent criteria for genomewide significance. Using 175 extended Icelandic families that included 596 patients with asthma, we performed a genomewide scan with 976 microsatellite markers. The families were identified by cross-matching a list of patients with asthma from the Department of Allergy/Pulmonary Medicine of the National University Hospital of Iceland with a genealogy database of the entire Icelandic nation. We detected linkage of asthma to chromosome 14q24, with an allele-sharing LOD score of 2.66. After we increased the marker density within the locus to an average of one microsatellite every 0.2 cM, the LOD score rose to 4.00. We designate this locus "asthma locus one" (AS1). Taken together, these results provide evidence of a novel susceptibility gene for asthma on chromosome 14q24.en
dc.language.isoenen
dc.publisherUniversity of Chicago Pressen
dc.relation.urlhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=379187en
dc.subject.meshAllelesen
dc.subject.meshAsthmaen
dc.subject.meshChromosome Mappingen
dc.subject.meshChromosomes, Human, Pair 14en
dc.subject.meshDatabases, Factualen
dc.subject.meshFemaleen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshLod Scoreen
dc.subject.meshMaleen
dc.subject.meshMicrosatellite Repeatsen
dc.subject.meshPedigreeen
dc.subject.meshRespiratory Function Testsen
dc.titleA major susceptibility gene for asthma maps to chromosome 14q24en
dc.typeArticleen
dc.contributor.departmentdeCODE Genetics, Inc., Reykjavik, Iceland. hakonh@decode.isen
dc.identifier.journalAmerican journal of human geneticsen

Related articles on PubMed

All Items in Hirsla are protected by copyright, with all rights reserved, unless otherwise indicated.