HLA-Cw6-positive and HLA-Cw6-negative patients with Psoriasis vulgaris have distinct clinical features.

2.50
Hdl Handle:
http://hdl.handle.net/2336/32452
Title:
HLA-Cw6-positive and HLA-Cw6-negative patients with Psoriasis vulgaris have distinct clinical features.
Authors:
Gudjonsson, Johann E; Karason, Ari; Antonsdottir, Arna A; Rúnarsdottir, E Hjaltey; Gulcher, Jeffrey R; Stefansson, Kari; Valdimarsson, Helgi
Citation:
J. Invest. Dermatol. 2002, 118(2):362-5
Issue Date:
1-Feb-2002
Abstract:
Psoriasis is associated with HLA-Cw6, and Caucasians who carry this allele have about a 10-fold increased risk of developing psoriasis. We have HLA-C typed 369 patients with familial psoriasis and compared the clinical features of the patients carrying HLA-Cw6 against those carrying other HLA-C types. Some striking clinical differences were observed between the two groups. Patients who are Cw6 positive had a lower age at onset (p=3x10(-7)). Cw6-positive women had an earlier disease onset than Cw6-positive men (p =0.02), but such a difference was not observed for the Cw6-negative patients. The guttate-type onset of psoriasis was mostly confined to this group (p=2x10(-4)) and persistent disseminated guttate-like papules were also predominantly observed in the Cw6-positive patients (p <10(-)4). The Cw6-positive patients also had more extensive plaques on their arms, legs, and trunk (p =0.001), more severe disease (p =0.003), higher incidence of the Koebner's phenomenon (p =0.005), reported more often that their psoriasis got worse during or after throat infections (p =0.02), and more often a favorable response to sunlight (p =0.008) In contrast, dystrophic nail changes were more common in the Cw6-negative patients (p =0.002) and also psoriatic arthritis, although this was not significant (p =0.135). It is concluded that patients with psoriasis have different clinical features depending on whether they are HLA-Cw6 positive or negative.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1046/j.0022-202x.2001.01656.x

Full metadata record

DC FieldValue Language
dc.contributor.authorGudjonsson, Johann E-
dc.contributor.authorKarason, Ari-
dc.contributor.authorAntonsdottir, Arna A-
dc.contributor.authorRúnarsdottir, E Hjaltey-
dc.contributor.authorGulcher, Jeffrey R-
dc.contributor.authorStefansson, Kari-
dc.contributor.authorValdimarsson, Helgi-
dc.date.accessioned2008-07-18T11:03:46Z-
dc.date.available2008-07-18T11:03:46Z-
dc.date.issued2002-02-01-
dc.date.submitted2008-07-18-
dc.identifier.citationJ. Invest. Dermatol. 2002, 118(2):362-5en
dc.identifier.issn0022-202X-
dc.identifier.pmid11841557-
dc.identifier.doi10.1046/j.0022-202x.2001.01656.x-
dc.identifier.urihttp://hdl.handle.net/2336/32452-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPsoriasis is associated with HLA-Cw6, and Caucasians who carry this allele have about a 10-fold increased risk of developing psoriasis. We have HLA-C typed 369 patients with familial psoriasis and compared the clinical features of the patients carrying HLA-Cw6 against those carrying other HLA-C types. Some striking clinical differences were observed between the two groups. Patients who are Cw6 positive had a lower age at onset (p=3x10(-7)). Cw6-positive women had an earlier disease onset than Cw6-positive men (p =0.02), but such a difference was not observed for the Cw6-negative patients. The guttate-type onset of psoriasis was mostly confined to this group (p=2x10(-4)) and persistent disseminated guttate-like papules were also predominantly observed in the Cw6-positive patients (p <10(-)4). The Cw6-positive patients also had more extensive plaques on their arms, legs, and trunk (p =0.001), more severe disease (p =0.003), higher incidence of the Koebner's phenomenon (p =0.005), reported more often that their psoriasis got worse during or after throat infections (p =0.02), and more often a favorable response to sunlight (p =0.008) In contrast, dystrophic nail changes were more common in the Cw6-negative patients (p =0.002) and also psoriatic arthritis, although this was not significant (p =0.135). It is concluded that patients with psoriasis have different clinical features depending on whether they are HLA-Cw6 positive or negative.en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.urlhttp://dx.doi.org/10.1046/j.0022-202x.2001.01656.xen
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAge of Onseten
dc.subject.meshAgeden
dc.subject.meshArthritis, Psoriaticen
dc.subject.meshChilden
dc.subject.meshChild, Preschoolen
dc.subject.meshCohort Studiesen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshInfanten
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshNail Diseasesen
dc.subject.meshPsoriasisen
dc.subject.meshSeverity of Illness Indexen
dc.subject.meshSex Characteristicsen
dc.titleHLA-Cw6-positive and HLA-Cw6-negative patients with Psoriasis vulgaris have distinct clinical features.en
dc.typeArticleen
dc.contributor.departmentDepartment of Immunology, National University Hospital of Iceland, Reykjavik, Iceland.en
dc.identifier.journalJournal of investigative dermatologyen

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