2.50
Hdl Handle:
http://hdl.handle.net/2336/32675
Title:
Localization of a gene for migraine without aura to chromosome 4q21.
Authors:
Bjornsson, Asgeir; Gudmundsson, Gretar; Gudfinnsson, Einar; Hrafnsdottir, María; Benedikz, John; Skuladottir, Svanhildur; Kristjansson, Kristleifur; Frigge, Michael L; Kong, Augustine; Stefansson, Kari; Gulcher, Jeffrey R
Citation:
Am. J. Hum. Genet. 2003, 73(5):986-93
Issue Date:
1-Nov-2003
Abstract:
Migraine is a common form of headache and has a significant genetic component. Here, we report linkage results from a study in Iceland of migraine without aura (MO). The study group comprised patients with migraine recruited by neurologists and from the registry of the Icelandic Migraine Society, as well as through the use of a questionnaire sent to a random sample of 20,000 Icelanders. Migraine diagnoses were made and confirmed using diagnostic criteria established by the International Headache Society. A genome-wide scan with multipoint allele-sharing methods was performed on 289 patients suffering from MO. Linkage was observed to a locus on chromosome 4q21 (LOD=2.05; P=.001). The locus reported here overlaps a locus (MGR1) reported elsewhere for patients with migraine with aura (MA) in the Finnish population. This replication of the MGR1 locus in families with MO indicates that the gene we have mapped may contribute to both MA and MO. Further analysis indicates that the linkage evidence improves for affected females and, especially, with a slightly relaxed definition of MO (LOD=4.08; P=7.2 x 10(-6)).
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1180504

Full metadata record

DC FieldValue Language
dc.contributor.authorBjornsson, Asgeir-
dc.contributor.authorGudmundsson, Gretar-
dc.contributor.authorGudfinnsson, Einar-
dc.contributor.authorHrafnsdottir, María-
dc.contributor.authorBenedikz, John-
dc.contributor.authorSkuladottir, Svanhildur-
dc.contributor.authorKristjansson, Kristleifur-
dc.contributor.authorFrigge, Michael L-
dc.contributor.authorKong, Augustine-
dc.contributor.authorStefansson, Kari-
dc.contributor.authorGulcher, Jeffrey R-
dc.date.accessioned2008-07-22T16:01:51Z-
dc.date.available2008-07-22T16:01:51Z-
dc.date.issued2003-11-01-
dc.date.submitted2008-07-22-
dc.identifier.citationAm. J. Hum. Genet. 2003, 73(5):986-93en
dc.identifier.issn0002-9297-
dc.identifier.pmid14513409-
dc.identifier.urihttp://hdl.handle.net/2336/32675-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractMigraine is a common form of headache and has a significant genetic component. Here, we report linkage results from a study in Iceland of migraine without aura (MO). The study group comprised patients with migraine recruited by neurologists and from the registry of the Icelandic Migraine Society, as well as through the use of a questionnaire sent to a random sample of 20,000 Icelanders. Migraine diagnoses were made and confirmed using diagnostic criteria established by the International Headache Society. A genome-wide scan with multipoint allele-sharing methods was performed on 289 patients suffering from MO. Linkage was observed to a locus on chromosome 4q21 (LOD=2.05; P=.001). The locus reported here overlaps a locus (MGR1) reported elsewhere for patients with migraine with aura (MA) in the Finnish population. This replication of the MGR1 locus in families with MO indicates that the gene we have mapped may contribute to both MA and MO. Further analysis indicates that the linkage evidence improves for affected females and, especially, with a slightly relaxed definition of MO (LOD=4.08; P=7.2 x 10(-6)).en
dc.language.isoenen
dc.publisherUniversity of Chicago Pressen
dc.relation.urlhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1180504en
dc.subject.meshAllelesen
dc.subject.meshChromosome Mappingen
dc.subject.meshChromosomes, Human, Pair 4en
dc.subject.meshFemaleen
dc.subject.meshFinlanden
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshLod Scoreen
dc.subject.meshMaleen
dc.subject.meshMigraine without Auraen
dc.titleLocalization of a gene for migraine without aura to chromosome 4q21.en
dc.typeArticleen
dc.contributor.departmentdeCODE Genetics, Reykjavik, Iceland. asgeir.bjornsson@decode.isen
dc.identifier.journalAmerican journal of human geneticsen

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