Serum samples from infants vaccinated with a pneumococcal conjugate vaccine, PncT, protect mice against invasive infection caused by Streptococcus pneumoniae serotypes 6A and 6B

2.50
Hdl Handle:
http://hdl.handle.net/2336/33013
Title:
Serum samples from infants vaccinated with a pneumococcal conjugate vaccine, PncT, protect mice against invasive infection caused by Streptococcus pneumoniae serotypes 6A and 6B
Authors:
Saeland, E; Jakobsen, H; Ingolfsdottir, G; Sigurdardottir, ST; Jonsdottir, I
Citation:
J. Infect. Dis. 2001, 183(2):253-260
Issue Date:
15-Jan-2001
Abstract:
Streptococcus pneumoniae serogroup 6 is an important cause of respiratory tract disease worldwide. Vaccination with 6B polysaccharide induces antibody response to the cross-reacting serotype 6A, but the protective capacity of 6A antibodies induced in infants remains unknown. In this study, passive immunization with serum samples obtained from infants vaccinated with an octavalent polysaccharide protein conjugate vaccine, PncT, protected mice against bacteremia and/or lung infection caused by intranasal challenge with serotypes 6B and 6A. Protective infant serum samples had significantly higher serotype-specific IgG levels and opsonic activity than did nonprotective serum samples. The protective level to either serotype was approximately 1 microg of specific IgG antibodies injected per mouse (corresponding to approximately 0.3 microg/mL). The protection was strongly related to opsonophagocytic antibody levels measured in vitro. These results demonstrate that PncT induces antibodies in infants that protect mice against invasive disease caused by the homologous serotype and by the cross-reacting serotype 6A.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.journals.uchicago.edu/doi/abs/10.1086/317934

Full metadata record

DC FieldValue Language
dc.contributor.authorSaeland, E-
dc.contributor.authorJakobsen, H-
dc.contributor.authorIngolfsdottir, G-
dc.contributor.authorSigurdardottir, ST-
dc.contributor.authorJonsdottir, I-
dc.date.accessioned2008-07-24T11:35:15Z-
dc.date.available2008-07-24T11:35:15Z-
dc.date.issued2001-01-15-
dc.date.submitted2008-07-24-
dc.identifier.citationJ. Infect. Dis. 2001, 183(2):253-260en
dc.identifier.issn0022-1899-
dc.identifier.pmid11110649-
dc.identifier.doi10.1086/317934-
dc.identifier.urihttp://hdl.handle.net/2336/33013-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractStreptococcus pneumoniae serogroup 6 is an important cause of respiratory tract disease worldwide. Vaccination with 6B polysaccharide induces antibody response to the cross-reacting serotype 6A, but the protective capacity of 6A antibodies induced in infants remains unknown. In this study, passive immunization with serum samples obtained from infants vaccinated with an octavalent polysaccharide protein conjugate vaccine, PncT, protected mice against bacteremia and/or lung infection caused by intranasal challenge with serotypes 6B and 6A. Protective infant serum samples had significantly higher serotype-specific IgG levels and opsonic activity than did nonprotective serum samples. The protective level to either serotype was approximately 1 microg of specific IgG antibodies injected per mouse (corresponding to approximately 0.3 microg/mL). The protection was strongly related to opsonophagocytic antibody levels measured in vitro. These results demonstrate that PncT induces antibodies in infants that protect mice against invasive disease caused by the homologous serotype and by the cross-reacting serotype 6A.en
dc.language.isoenen
dc.publisherUniversity of Chicago Pressen
dc.relation.urlhttp://www.journals.uchicago.edu/doi/abs/10.1086/317934en
dc.subject.meshAnimalsen
dc.subject.meshAntibodies, Bacterialen
dc.subject.meshAntibody Affinityen
dc.subject.meshBacteremiaen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshImmunization, Passiveen
dc.subject.meshImmunoglobulin Gen
dc.subject.meshImmunoglobulin Men
dc.subject.meshInfanten
dc.subject.meshLung Diseasesen
dc.subject.meshMiceen
dc.subject.meshOpsonin Proteinsen
dc.subject.meshPneumococcal Infectionsen
dc.subject.meshPneumococcal Vaccinesen
dc.subject.meshSerotypingen
dc.subject.meshStreptococcus pneumoniaeen
dc.subject.meshTetanus Toxoiden
dc.subject.meshVaccines, Conjugateen
dc.titleSerum samples from infants vaccinated with a pneumococcal conjugate vaccine, PncT, protect mice against invasive infection caused by Streptococcus pneumoniae serotypes 6A and 6Ben
dc.typeArticleen
dc.contributor.departmentDepartment of Immunology, Landspitali-University Hospital, Hringbraut, 101 Reykjavik, Iceland.en
dc.identifier.journalJournal of infectious diseasesen

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