Comparative study of the effects of a progestogen-only pill containing desogestrel and an intrauterine contraceptive device in lactating women

2.50
Hdl Handle:
http://hdl.handle.net/2336/33338
Title:
Comparative study of the effects of a progestogen-only pill containing desogestrel and an intrauterine contraceptive device in lactating women
Authors:
Bjarnadottir, RI; Gottfredsdottir, H; Sigurdardottir, K; Geirsson, RT; Dieben, TO
Citation:
BJOG 2001, 108(11):1174-80
Issue Date:
1-Nov-2001
Abstract:
OBJECTIVE: To evaluate the effects of desogestrel 75 microg/day, as a progestogen-only pill compared with a copper-bearing intrauterine contraceptive device (IUCD) on lactation and to study the safety of both treatments in mothers and children. Transfer of etonogestrel to breast milk was studied in a subgroup of desogestrel users. The children were to be followed up until 2.5 years of age. DESIGN: An open, non-randomised, group-comparative study in lactating women. SETTING: University Hospital, Reykjavik, Iceland. PARTICIPANTS: A total of 83 lactating women; 42 received desogestrel and 41 had an IUCD inserted for seven consecutive treatment cycles of 28 days. METHODS: Evaluation visits were planned at baseline and at the end of treatment cycles 1, 4 and 7. The amount of breast milk was determined by weighing the infants before and after feeding, at baseline and after treatment cycles I and 4. Milk samples were obtained at the same time for constituent measurements. Safety was studied by structured medical examinations and by recording adverse experiences in mothers and children. RESULTS: There were no significant differences between the desogestrel and IUCD groups in composition and quantity of breast milk nor in growth and development of the children followed up to the age of 2.5 years. In the desogestrel group a slightly higher incidence of mild adverse experiences of a hormonal nature was reported among both mothers and infants. Of the children 82% were followed until 1.5 years of age and 50% until 2.5 years. CONCLUSION: The use of desogestrel 75 microg/day did not change the amount and composition of breast milk nor did it affect growth and development of the breastfed children. It appears to be a safe and effective contraceptive method for lactating women
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1111/j.1471-0528.2001.00239.x

Full metadata record

DC FieldValue Language
dc.contributor.authorBjarnadottir, RI-
dc.contributor.authorGottfredsdottir, H-
dc.contributor.authorSigurdardottir, K-
dc.contributor.authorGeirsson, RT-
dc.contributor.authorDieben, TO-
dc.date.accessioned2008-07-28T10:00:50Z-
dc.date.available2008-07-28T10:00:50Z-
dc.date.issued2001-11-01-
dc.date.submitted2008-07-28-
dc.identifier.citationBJOG 2001, 108(11):1174-80en
dc.identifier.issn1470-0328-
dc.identifier.pmid11762658-
dc.identifier.doi10.1111/j.1471-0528.2001.00239.x-
dc.identifier.urihttp://hdl.handle.net/2336/33338-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVE: To evaluate the effects of desogestrel 75 microg/day, as a progestogen-only pill compared with a copper-bearing intrauterine contraceptive device (IUCD) on lactation and to study the safety of both treatments in mothers and children. Transfer of etonogestrel to breast milk was studied in a subgroup of desogestrel users. The children were to be followed up until 2.5 years of age. DESIGN: An open, non-randomised, group-comparative study in lactating women. SETTING: University Hospital, Reykjavik, Iceland. PARTICIPANTS: A total of 83 lactating women; 42 received desogestrel and 41 had an IUCD inserted for seven consecutive treatment cycles of 28 days. METHODS: Evaluation visits were planned at baseline and at the end of treatment cycles 1, 4 and 7. The amount of breast milk was determined by weighing the infants before and after feeding, at baseline and after treatment cycles I and 4. Milk samples were obtained at the same time for constituent measurements. Safety was studied by structured medical examinations and by recording adverse experiences in mothers and children. RESULTS: There were no significant differences between the desogestrel and IUCD groups in composition and quantity of breast milk nor in growth and development of the children followed up to the age of 2.5 years. In the desogestrel group a slightly higher incidence of mild adverse experiences of a hormonal nature was reported among both mothers and infants. Of the children 82% were followed until 1.5 years of age and 50% until 2.5 years. CONCLUSION: The use of desogestrel 75 microg/day did not change the amount and composition of breast milk nor did it affect growth and development of the breastfed children. It appears to be a safe and effective contraceptive method for lactating womenen
dc.language.isoenen
dc.publisherBlackwell Pub.en
dc.relation.urlhttp://dx.doi.org/10.1111/j.1471-0528.2001.00239.xen
dc.subject.meshAdulten
dc.subject.meshBreast Feedingen
dc.subject.meshContraceptives, Oral, Syntheticen
dc.subject.meshDesogestrelen
dc.subject.meshFemaleen
dc.subject.meshGrowthen
dc.subject.meshHumansen
dc.subject.meshInfanten
dc.subject.meshInfant, Newbornen
dc.subject.meshIntrauterine Devicesen
dc.subject.meshLactationen
dc.subject.meshMilk, Humanen
dc.subject.meshTabletsen
dc.titleComparative study of the effects of a progestogen-only pill containing desogestrel and an intrauterine contraceptive device in lactating womenen
dc.typeArticleen
dc.contributor.departmentDepartment of Obstetrics and Gynaecology, University Hospital, Reykjavik, Iceland.en
dc.identifier.journalBJOG : an international journal of obstetrics and gynaecologyen

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