The frequency of CLA+ CD8+ T cells in the blood of psoriasis patients correlates closely with the severity of their disease

2.50
Hdl Handle:
http://hdl.handle.net/2336/33340
Title:
The frequency of CLA+ CD8+ T cells in the blood of psoriasis patients correlates closely with the severity of their disease
Authors:
Sigmundsdottir, H; Gudjonsson, JE; Jonsdottir, I; Ludviksson, BR; Valdimarsson, H
Citation:
Clin. Exp. Immunol. 2001, 126(2):365-9
Issue Date:
1-Nov-2001
Abstract:
Psoriasis is thought to be a T cell-mediated skin disease and the cutaneous lymphocyte antigen (CLA) is an important skin homing epitope for T cells. We have studied the relationship between disease severity (PASI) and phenotypic analysis of T cells in the blood of 36 patients with psoriasis focusing on the expression of CLA, VLA-4 and CD25 on CD4+ and CD8+ T cells. The patients had a higher frequency of circulating CLA+ CD8+ cells than healthy controls. Furthermore, a much stronger correlation was observed between PASI and the frequency of CLA+ CD8+ than CLA+ CD4+ T cells. The frequency of CLA+D8+ T cells correlated more strongly with redness, thickness and scaling of the skin lesions than the total affected body surface area. In contrast to CLA the T cell expression of VLA-4 did not demonstrate any such correlation. Finally, the expression of the activation marker CD25 on CD8+ T cells showed a strong correlation with disease severity in patients with moderate to severe psoriasis (PASI > 10) but such correlation was not observed for CD4+ T cells. These findings support the notion that circulating CLA+ CD8+ T cells may play an important role in the pathogenesis of psoriasis.
Description:
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Additional Links:
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1906191

Full metadata record

DC FieldValue Language
dc.contributor.authorSigmundsdottir, H-
dc.contributor.authorGudjonsson, JE-
dc.contributor.authorJonsdottir, I-
dc.contributor.authorLudviksson, BR-
dc.contributor.authorValdimarsson, H-
dc.date.accessioned2008-07-28T11:29:55Z-
dc.date.available2008-07-28T11:29:55Z-
dc.date.issued2001-11-01-
dc.date.submitted2008-07-28-
dc.identifier.citationClin. Exp. Immunol. 2001, 126(2):365-9en
dc.identifier.issn0009-9104-
dc.identifier.pmid11703383-
dc.identifier.doi10.1111/j.1365-2249.2001.01688.x-
dc.identifier.urihttp://hdl.handle.net/2336/33340-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPsoriasis is thought to be a T cell-mediated skin disease and the cutaneous lymphocyte antigen (CLA) is an important skin homing epitope for T cells. We have studied the relationship between disease severity (PASI) and phenotypic analysis of T cells in the blood of 36 patients with psoriasis focusing on the expression of CLA, VLA-4 and CD25 on CD4+ and CD8+ T cells. The patients had a higher frequency of circulating CLA+ CD8+ cells than healthy controls. Furthermore, a much stronger correlation was observed between PASI and the frequency of CLA+ CD8+ than CLA+ CD4+ T cells. The frequency of CLA+D8+ T cells correlated more strongly with redness, thickness and scaling of the skin lesions than the total affected body surface area. In contrast to CLA the T cell expression of VLA-4 did not demonstrate any such correlation. Finally, the expression of the activation marker CD25 on CD8+ T cells showed a strong correlation with disease severity in patients with moderate to severe psoriasis (PASI > 10) but such correlation was not observed for CD4+ T cells. These findings support the notion that circulating CLA+ CD8+ T cells may play an important role in the pathogenesis of psoriasis.en
dc.language.isoenen
dc.publisherBlackwell Scientific Publicationsen
dc.relation.urlhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1906191en
dc.subject.meshAntigens, Neoplasmen
dc.subject.meshCD4-Positive T-Lymphocytesen
dc.subject.meshCD8-Positive T-Lymphocytesen
dc.subject.meshCase-Control Studiesen
dc.subject.meshHumansen
dc.subject.meshMembrane Glycoproteinsen
dc.subject.meshPsoriasisen
dc.subject.meshReceptors, Interleukin-2en
dc.subject.meshT-Lymphocyte Subsetsen
dc.titleThe frequency of CLA+ CD8+ T cells in the blood of psoriasis patients correlates closely with the severity of their diseaseen
dc.typeArticleen
dc.contributor.departmentDepartment of Immunology, Landspítali University Hospital, Reykjavík, Iceland.en
dc.identifier.journalClinical and experimental immunologyen
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