Lower extremity blood flow in healthy men: effect of smoking, cholesterol, and physical activity - a Doppler study

2.50
Hdl Handle:
http://hdl.handle.net/2336/33492
Title:
Lower extremity blood flow in healthy men: effect of smoking, cholesterol, and physical activity - a Doppler study
Authors:
Asgeirsdottir, LP; Agnarsson, U; Jonsson, GS
Citation:
Angiology. 2001, 52(7):437-45
Issue Date:
1-Jul-2001
Abstract:
Tobacco smoking is one of the principal risk factors of peripheral arterial disease (PAD); cholesterol level has a lesser impact. The effect of leisure-time physical activity (LTPA) has not been studied in depth. The aim of this study was to determine the relative effects of smoking, total cholesterol, and leisure-time physical activity on blood flow parameters in the lower extremities of healthy middle-aged men with no prior symptoms or diagnosis of PAD. The authors examined 130 men, aged 40-65 years, free of known arterial disease and hypertension. The men had either a total cholesterol concentration of < 5.7 or > 7.0 mmol/L, and were either smokers or nonsmokers. LTPA was addressed by a questionnaire. Ankle-brachial index (ABI) was calculated and Doppler examination of the femoral artery was performed before and after an exercise test. Tobacco smoking related significantly to abnormal ABI and Doppler results (odds ratio [OR] 2.42) while the total cholesterol level did not. LTPA had a favorable effect (OR 0.51). Abnormal ABI response was greatest in smokers with high total cholesterol (p < 0.01). Tobacco smoking is a significant risk factor for abnormal ABI response and blood flow abnormalities in healthy men. Regular physical activity has a measurable protective effect. An abnormal ABI suggests early atherosclerosis and indicates risk factor assessment and physician intervention.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://ang.sagepub.com/cgi/content/abstract/52/7/437

Full metadata record

DC FieldValue Language
dc.contributor.authorAsgeirsdottir, LP-
dc.contributor.authorAgnarsson, U-
dc.contributor.authorJonsson, GS-
dc.date.accessioned2008-07-28T15:30:00Z-
dc.date.available2008-07-28T15:30:00Z-
dc.date.issued2001-07-01-
dc.date.submitted2008-07-28-
dc.identifier.citationAngiology. 2001, 52(7):437-45en
dc.identifier.issn0003-3197-
dc.identifier.pmid11515982-
dc.identifier.doi10.1177/000331970105200701-
dc.identifier.urihttp://hdl.handle.net/2336/33492-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractTobacco smoking is one of the principal risk factors of peripheral arterial disease (PAD); cholesterol level has a lesser impact. The effect of leisure-time physical activity (LTPA) has not been studied in depth. The aim of this study was to determine the relative effects of smoking, total cholesterol, and leisure-time physical activity on blood flow parameters in the lower extremities of healthy middle-aged men with no prior symptoms or diagnosis of PAD. The authors examined 130 men, aged 40-65 years, free of known arterial disease and hypertension. The men had either a total cholesterol concentration of < 5.7 or > 7.0 mmol/L, and were either smokers or nonsmokers. LTPA was addressed by a questionnaire. Ankle-brachial index (ABI) was calculated and Doppler examination of the femoral artery was performed before and after an exercise test. Tobacco smoking related significantly to abnormal ABI and Doppler results (odds ratio [OR] 2.42) while the total cholesterol level did not. LTPA had a favorable effect (OR 0.51). Abnormal ABI response was greatest in smokers with high total cholesterol (p < 0.01). Tobacco smoking is a significant risk factor for abnormal ABI response and blood flow abnormalities in healthy men. Regular physical activity has a measurable protective effect. An abnormal ABI suggests early atherosclerosis and indicates risk factor assessment and physician intervention.en
dc.language.isoenen
dc.publisherSage Publicationsen
dc.relation.urlhttp://ang.sagepub.com/cgi/content/abstract/52/7/437en
dc.subject.meshAgeden
dc.subject.meshCholesterolen
dc.subject.meshExertionen
dc.subject.meshFemoral Arteryen
dc.subject.meshHumansen
dc.subject.meshLaser-Doppler Flowmetryen
dc.subject.meshLegen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshQuestionnairesen
dc.subject.meshRisk Factorsen
dc.subject.meshSmokingen
dc.titleLower extremity blood flow in healthy men: effect of smoking, cholesterol, and physical activity - a Doppler studyen
dc.typeArticleen
dc.contributor.departmentNoninvasive Vascular Laboratory, University Hospital, Reykjavik, Iceland.en
dc.identifier.journalAngiologyen

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