The influence of partial or total thymectomy during open heart surgery in infants on the immune function later in life

2.50
Hdl Handle:
http://hdl.handle.net/2336/3360
Title:
The influence of partial or total thymectomy during open heart surgery in infants on the immune function later in life
Authors:
Eysteinsdottir, J H; Freysdottir, J; Haraldsson, A; Stefansdottir, J; Skaftadottir, I; Helgason, H; Ogmundsdottir, H M
Citation:
Clin. Exp. Immunol. 2004, 136(2):349-55
Issue Date:
2004
Abstract:
Infants undergoing open heart surgery often have all or part of their thymus removed. The activity of the immune system has not been investigated thoroughly in these children, and only shortly after the operation. Therefore, it was decided to investigate the activity of the immune system in more detail in children several years after their operation. Peripheral blood samples from 19 children who had undergone open heart surgery during their first months of life was collected (study group) and from 19 age- and gender-matched children (control group). The activity of the immune system was evaluated by measuring the number of different cell types in peripheral blood, the phenotype of lymphocytes and the response of T cells following in vitro stimulation by mitogen, tetanus toxoid and measles antigen. The study group had significantly lower counts of total lymphocytes, which was reflected in a lower number of T cells but not B cells. Furthermore, the study group had significantly lower proportion of T cells (CD3(+)) and helper T cells (CD4(+)), but not cytotoxic T cells (CD8(+)). The level of neutrophils in peripheral blood was significantly higher in the study group. This may indicate enhanced innate immunity when the acquired immunity is defective. The results indicate a shift to extrathymic T cell maturation, which is less efficient for CD4(+) helper cells than for CD8(+) cytotoxic cells.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2249.2004.02437.x

Full metadata record

DC FieldValue Language
dc.contributor.authorEysteinsdottir, J H-
dc.contributor.authorFreysdottir, J-
dc.contributor.authorHaraldsson, A-
dc.contributor.authorStefansdottir, J-
dc.contributor.authorSkaftadottir, I-
dc.contributor.authorHelgason, H-
dc.contributor.authorOgmundsdottir, H M-
dc.date.accessioned2006-07-10T12:14:05Z-
dc.date.available2006-07-10T12:14:05Z-
dc.date.issued2004-
dc.identifier.citationClin. Exp. Immunol. 2004, 136(2):349-55en
dc.identifier.issn0009-9104-
dc.identifier.pmid15086401-
dc.identifier.doi10.1111/j.1365-2249.2004.02437.x-
dc.identifier.otherPED12en
dc.identifier.otherAAI12en
dc.identifier.urihttp://hdl.handle.net/2336/3360-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractInfants undergoing open heart surgery often have all or part of their thymus removed. The activity of the immune system has not been investigated thoroughly in these children, and only shortly after the operation. Therefore, it was decided to investigate the activity of the immune system in more detail in children several years after their operation. Peripheral blood samples from 19 children who had undergone open heart surgery during their first months of life was collected (study group) and from 19 age- and gender-matched children (control group). The activity of the immune system was evaluated by measuring the number of different cell types in peripheral blood, the phenotype of lymphocytes and the response of T cells following in vitro stimulation by mitogen, tetanus toxoid and measles antigen. The study group had significantly lower counts of total lymphocytes, which was reflected in a lower number of T cells but not B cells. Furthermore, the study group had significantly lower proportion of T cells (CD3(+)) and helper T cells (CD4(+)), but not cytotoxic T cells (CD8(+)). The level of neutrophils in peripheral blood was significantly higher in the study group. This may indicate enhanced innate immunity when the acquired immunity is defective. The results indicate a shift to extrathymic T cell maturation, which is less efficient for CD4(+) helper cells than for CD8(+) cytotoxic cells.en
dc.language.isoenen
dc.publisherBlackwellen
dc.relation.urlhttp://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2249.2004.02437.xen
dc.subjectAntigens, Viralen
dc.subjectB-Lymphocytesen
dc.subjectCD4-Positive T-Lymphocytesen
dc.subjectCD8-Positive T-Lymphocytesen
dc.subjectCase-Control Studiesen
dc.subjectCells, Cultureden
dc.subjectChi-Square Distributionen
dc.subjectFollow-Up Studiesen
dc.subjectHeart Defects, Congenitalen
dc.subjectHumansen
dc.subjectImmune Systemen
dc.subjectImmunoglobulinsen
dc.subjectInfant, Newbornen
dc.subjectLymphocyte Activationen
dc.subjectLymphocyte Counten
dc.subjectMeasles virusen
dc.subjectMitogensen
dc.subjectResearch Support, Non-U.S. Gov'ten
dc.subjectTetanus Toxoiden
dc.subjectThymectomyen
dc.titleThe influence of partial or total thymectomy during open heart surgery in infants on the immune function later in lifeen
dc.typeArticleen
dc.identifier.journalClinical and experimental immunologyen
dc.format.digYES-

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