2.50
Hdl Handle:
http://hdl.handle.net/2336/33894
Title:
Genetics of gene expression and its effect on disease
Authors:
Emilsson, Valur; Thorleifsson, Gudmar; Zhang, Bin; Leonardson, Amy S; Zink, Florian; Zhu, Jun; Carlson, Sonia; Helgason, Agnar; Walters, G Bragi; Gunnarsdottir, Steinunn; Mouy, Magali; Steinthorsdottir, Valgerdur; Eiriksdottir, Gudrun H; Bjornsdottir, Gyda; Reynisdottir, Inga; Gudbjartsson, Daniel; Helgadottir, Anna; Jonasdottir, Aslaug; Jonasdottir, Adalbjorg; Styrkarsdottir, Unnur; Gretarsdottir, Solveig; Magnusson, Kristinn P; Stefansson, Hreinn; Fossdal, Ragnheidur; Kristjansson, Kristleifur; Gislason, Hjortur G; Stefansson, Tryggvi; Leifsson, Bjorn G; Thorsteinsdottir, Unnur; Lamb, John R; Gulcher, Jeffrey R; Reitman, Marc L; Kong, Augustine; Schadt, Eric E; Stefansson, Kari
Citation:
Nature 2008, 452(7186):423-8
Issue Date:
27-Mar-2008
Abstract:
Common human diseases result from the interplay of many genes and environmental factors. Therefore, a more integrative biology approach is needed to unravel the complexity and causes of such diseases. To elucidate the complexity of common human diseases such as obesity, we have analysed the expression of 23,720 transcripts in large population-based blood and adipose tissue cohorts comprehensively assessed for various phenotypes, including traits related to clinical obesity. In contrast to the blood expression profiles, we observed a marked correlation between gene expression in adipose tissue and obesity-related traits. Genome-wide linkage and association mapping revealed a highly significant genetic component to gene expression traits, including a strong genetic effect of proximal (cis) signals, with 50% of the cis signals overlapping between the two tissues profiled. Here we demonstrate an extensive transcriptional network constructed from the human adipose data that exhibits significant overlap with similar network modules constructed from mouse adipose data. A core network module in humans and mice was identified that is enriched for genes involved in the inflammatory and immune response and has been found to be causally associated to obesity-related traits.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1038/nature06758

Full metadata record

DC FieldValue Language
dc.contributor.authorEmilsson, Valur-
dc.contributor.authorThorleifsson, Gudmar-
dc.contributor.authorZhang, Bin-
dc.contributor.authorLeonardson, Amy S-
dc.contributor.authorZink, Florian-
dc.contributor.authorZhu, Jun-
dc.contributor.authorCarlson, Sonia-
dc.contributor.authorHelgason, Agnar-
dc.contributor.authorWalters, G Bragi-
dc.contributor.authorGunnarsdottir, Steinunn-
dc.contributor.authorMouy, Magali-
dc.contributor.authorSteinthorsdottir, Valgerdur-
dc.contributor.authorEiriksdottir, Gudrun H-
dc.contributor.authorBjornsdottir, Gyda-
dc.contributor.authorReynisdottir, Inga-
dc.contributor.authorGudbjartsson, Daniel-
dc.contributor.authorHelgadottir, Anna-
dc.contributor.authorJonasdottir, Aslaug-
dc.contributor.authorJonasdottir, Adalbjorg-
dc.contributor.authorStyrkarsdottir, Unnur-
dc.contributor.authorGretarsdottir, Solveig-
dc.contributor.authorMagnusson, Kristinn P-
dc.contributor.authorStefansson, Hreinn-
dc.contributor.authorFossdal, Ragnheidur-
dc.contributor.authorKristjansson, Kristleifur-
dc.contributor.authorGislason, Hjortur G-
dc.contributor.authorStefansson, Tryggvi-
dc.contributor.authorLeifsson, Bjorn G-
dc.contributor.authorThorsteinsdottir, Unnur-
dc.contributor.authorLamb, John R-
dc.contributor.authorGulcher, Jeffrey R-
dc.contributor.authorReitman, Marc L-
dc.contributor.authorKong, Augustine-
dc.contributor.authorSchadt, Eric E-
dc.contributor.authorStefansson, Kari-
dc.date.accessioned2008-08-01T13:23:21Z-
dc.date.available2008-08-01T13:23:21Z-
dc.date.issued2008-03-27-
dc.date.submitted2008-08-01-
dc.identifier.citationNature 2008, 452(7186):423-8en
dc.identifier.issn1476-4687-
dc.identifier.pmid18344981-
dc.identifier.doi10.1038/nature06758-
dc.identifier.urihttp://hdl.handle.net/2336/33894-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractCommon human diseases result from the interplay of many genes and environmental factors. Therefore, a more integrative biology approach is needed to unravel the complexity and causes of such diseases. To elucidate the complexity of common human diseases such as obesity, we have analysed the expression of 23,720 transcripts in large population-based blood and adipose tissue cohorts comprehensively assessed for various phenotypes, including traits related to clinical obesity. In contrast to the blood expression profiles, we observed a marked correlation between gene expression in adipose tissue and obesity-related traits. Genome-wide linkage and association mapping revealed a highly significant genetic component to gene expression traits, including a strong genetic effect of proximal (cis) signals, with 50% of the cis signals overlapping between the two tissues profiled. Here we demonstrate an extensive transcriptional network constructed from the human adipose data that exhibits significant overlap with similar network modules constructed from mouse adipose data. A core network module in humans and mice was identified that is enriched for genes involved in the inflammatory and immune response and has been found to be causally associated to obesity-related traits.en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.urlhttp://dx.doi.org/10.1038/nature06758en
dc.subject.meshAdipose Tissueen
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshAnimalsen
dc.subject.meshBlooden
dc.subject.meshBody Mass Indexen
dc.subject.meshCohort Studiesen
dc.subject.meshEuropean Continental Ancestry Groupen
dc.subject.meshFemaleen
dc.subject.meshGene Expression Profilingen
dc.subject.meshGene Expression Regulationen
dc.subject.meshGenome, Humanen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshLod Scoreen
dc.subject.meshMaleen
dc.subject.meshMiceen
dc.subject.meshMiddle Ageden
dc.subject.meshObesityen
dc.subject.meshPolymorphism, Single Nucleotideen
dc.subject.meshQuantitative Trait Locien
dc.subject.meshSample Sizeen
dc.subject.meshWaist-Hip Ratioen
dc.titleGenetics of gene expression and its effect on diseaseen
dc.typeArticleen
dc.contributor.departmentdeCODE genetics, 101 Reykjavik, Iceland.en
dc.identifier.journalNatureen

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