Fine mapping of the SLEB2 locus involved in susceptibility to systemic lupus erythematosus.

2.50
Hdl Handle:
http://hdl.handle.net/2336/34092
Title:
Fine mapping of the SLEB2 locus involved in susceptibility to systemic lupus erythematosus.
Authors:
Magnusson, V; Lindqvist, A K; Castillejo-López, C; Kristjánsdottir, H; Steinsson, K; Gröndal, G; Sturfelt, G; Truedsson, L; Svenungsson, E; Lundberg, I; Gunnarsson, I; Bolstad, A I; Haga, H J; Jonsson, R; Klareskog, L; Alcocer-Varela, J; Alarcón-Segovia, D; Terwilliger, J D; Gyllensten, U B; Alarcón-Riquelme, M E
Citation:
Genomics. 2000, 70(3):307-14
Issue Date:
15-Dec-2000
Abstract:
We have previously reported linkage of systemic lupus erythematosus to chromosome 2q37 in multicase families from Iceland and Sweden. This locus (SLEB2) was identified by linkage to the markers D2S125 and D2S140. In the present study we have analyzed additional microsatellite markers and SNPs covering a region of 30 cM around D2S125 in an extended set of Nordic families (Icelandic, Swedish, and Norwegian). Two-point linkage analysis in these families gave a maximum lod score at the position of markers D2S2585 and D2S2985 (Z = 4.51, PIC = 0.65), by applying a "model-free" pseudo-marker linkage analysis. Based on multipoint linkage analysis in the Nordic families, the most likely location of the SLEB2 locus is estimated to be in the interval between D2S125 and the position of markers D2S2585 and D2S2985, with a peak multipoint lod score of Z = 6.03, assuming a dominant pseudo-marker model. Linkage disequilibrium (LD) analysis was performed using the data from the multicase families and 89 single-case families of Swedish origin, using the same set of markers. The LD analysis showed evidence for association in the single-case and multicase families with locus GAAT3C11 (P < 0.0003), and weak evidence for association was obtained for several markers located telomeric to D2S125 in the multicase families. Thirteen Mexican families were analyzed separately and found not to have linkage to this region. Our results support the presence of the SLEB2 locus at 2q37.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.sciencedirect.com/science/article/B6WG1-45F4M8J-5/2/768e5b959997264ec0d27ee8abe633a6

Full metadata record

DC FieldValue Language
dc.contributor.authorMagnusson, V-
dc.contributor.authorLindqvist, A K-
dc.contributor.authorCastillejo-López, C-
dc.contributor.authorKristjánsdottir, H-
dc.contributor.authorSteinsson, K-
dc.contributor.authorGröndal, G-
dc.contributor.authorSturfelt, G-
dc.contributor.authorTruedsson, L-
dc.contributor.authorSvenungsson, E-
dc.contributor.authorLundberg, I-
dc.contributor.authorGunnarsson, I-
dc.contributor.authorBolstad, A I-
dc.contributor.authorHaga, H J-
dc.contributor.authorJonsson, R-
dc.contributor.authorKlareskog, L-
dc.contributor.authorAlcocer-Varela, J-
dc.contributor.authorAlarcón-Segovia, D-
dc.contributor.authorTerwilliger, J D-
dc.contributor.authorGyllensten, U B-
dc.contributor.authorAlarcón-Riquelme, M E-
dc.date.accessioned2008-08-05T09:07:34Z-
dc.date.available2008-08-05T09:07:34Z-
dc.date.issued2000-12-15-
dc.date.submitted2008-08-05-
dc.identifier.citationGenomics. 2000, 70(3):307-14en
dc.identifier.issn0888-7543-
dc.identifier.pmid11161781-
dc.identifier.doi10.1006/geno.2000.6374-
dc.identifier.urihttp://hdl.handle.net/2336/34092-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractWe have previously reported linkage of systemic lupus erythematosus to chromosome 2q37 in multicase families from Iceland and Sweden. This locus (SLEB2) was identified by linkage to the markers D2S125 and D2S140. In the present study we have analyzed additional microsatellite markers and SNPs covering a region of 30 cM around D2S125 in an extended set of Nordic families (Icelandic, Swedish, and Norwegian). Two-point linkage analysis in these families gave a maximum lod score at the position of markers D2S2585 and D2S2985 (Z = 4.51, PIC = 0.65), by applying a "model-free" pseudo-marker linkage analysis. Based on multipoint linkage analysis in the Nordic families, the most likely location of the SLEB2 locus is estimated to be in the interval between D2S125 and the position of markers D2S2585 and D2S2985, with a peak multipoint lod score of Z = 6.03, assuming a dominant pseudo-marker model. Linkage disequilibrium (LD) analysis was performed using the data from the multicase families and 89 single-case families of Swedish origin, using the same set of markers. The LD analysis showed evidence for association in the single-case and multicase families with locus GAAT3C11 (P < 0.0003), and weak evidence for association was obtained for several markers located telomeric to D2S125 in the multicase families. Thirteen Mexican families were analyzed separately and found not to have linkage to this region. Our results support the presence of the SLEB2 locus at 2q37.en
dc.language.isoenen
dc.publisherAcademic Pressen
dc.relation.urlhttp://www.sciencedirect.com/science/article/B6WG1-45F4M8J-5/2/768e5b959997264ec0d27ee8abe633a6en
dc.subject.meshBase Sequenceen
dc.subject.meshChromosome Mappingen
dc.subject.meshChromosomes, Human, Pair 2en
dc.subject.meshDNA Primersen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshGenetics, Populationen
dc.subject.meshHumansen
dc.subject.meshLikelihood Functionsen
dc.subject.meshLinkage (Genetics)en
dc.subject.meshLupus Erythematosus, Systemicen
dc.titleFine mapping of the SLEB2 locus involved in susceptibility to systemic lupus erythematosus.en
dc.typeArticleen
dc.contributor.departmentDepartment of Genetics and Pathology and Uppsala Genotyping Center, Uppsala University, Uppsala, 751 85, Sweden.en
dc.identifier.journalGenomicsen

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