2.50
Hdl Handle:
http://hdl.handle.net/2336/34173
Title:
Familial aggregation of Parkinson's disease in Iceland
Authors:
Sveinbjornsdottir, S; Hicks, A A; Jonsson, T; Petursson, H; Gudmundsson, G; Frigge, M L; Kong, A; Gulcher, J R; Stefansson, K
Citation:
N. Engl. J. Med. 2000, 343(24):1765-70
Issue Date:
14-Dec-2000
Abstract:
BACKGROUND: The role of genetics in early-onset Parkinson's disease has been established, but whether there is a genetic contribution to the more common, late-onset form remains uncertain. METHODS: We reviewed the medical records and confirmed the diagnosis of Parkinson's disease in 772 living and deceased patients in whom the disease had been diagnosed during the previous 50 years in Iceland. With the use of an extensive computerized data base containing genealogic information on 610,920 people in Iceland during the past 11 centuries, several analyses were conducted to determine whether the patients were more related to each other than random members of the population (control subjects). RESULTS: Patients with Parkinson's disease, including a subgroup of 560 patients with late-onset disease (onset at >50 years of age), were significantly more related to each other than were subjects in matched groups of controls, and this relatedness extended beyond the nuclear family. The risk ratio for Parkinson's disease was 6.7 (95 percent confidence interval, 4.3 to 9.6) for siblings, 3.2 (95 percent confidence interval, 1.2 to 7.8) for offspring, and 2.7 (95 percent confidence interval, 1.6 to 3.9) for nephews and nieces of patients with late-onset Parkinson's disease. CONCLUSIONS: Late-onset Parkinson's disease has a genetic component as well as an environmental component.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://content.nejm.org/cgi/content/abstract/343/24/1765

Full metadata record

DC FieldValue Language
dc.contributor.authorSveinbjornsdottir, S-
dc.contributor.authorHicks, A A-
dc.contributor.authorJonsson, T-
dc.contributor.authorPetursson, H-
dc.contributor.authorGudmundsson, G-
dc.contributor.authorFrigge, M L-
dc.contributor.authorKong, A-
dc.contributor.authorGulcher, J R-
dc.contributor.authorStefansson, K-
dc.date.accessioned2008-08-05T11:24:02Z-
dc.date.available2008-08-05T11:24:02Z-
dc.date.issued2000-12-14-
dc.date.submitted2008-08-05-
dc.identifier.citationN. Engl. J. Med. 2000, 343(24):1765-70en
dc.identifier.issn0028-4793-
dc.identifier.pmid11114315-
dc.identifier.doi10.1056/NEJM200012143432404-
dc.identifier.urihttp://hdl.handle.net/2336/34173-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: The role of genetics in early-onset Parkinson's disease has been established, but whether there is a genetic contribution to the more common, late-onset form remains uncertain. METHODS: We reviewed the medical records and confirmed the diagnosis of Parkinson's disease in 772 living and deceased patients in whom the disease had been diagnosed during the previous 50 years in Iceland. With the use of an extensive computerized data base containing genealogic information on 610,920 people in Iceland during the past 11 centuries, several analyses were conducted to determine whether the patients were more related to each other than random members of the population (control subjects). RESULTS: Patients with Parkinson's disease, including a subgroup of 560 patients with late-onset disease (onset at >50 years of age), were significantly more related to each other than were subjects in matched groups of controls, and this relatedness extended beyond the nuclear family. The risk ratio for Parkinson's disease was 6.7 (95 percent confidence interval, 4.3 to 9.6) for siblings, 3.2 (95 percent confidence interval, 1.2 to 7.8) for offspring, and 2.7 (95 percent confidence interval, 1.6 to 3.9) for nephews and nieces of patients with late-onset Parkinson's disease. CONCLUSIONS: Late-onset Parkinson's disease has a genetic component as well as an environmental component.en
dc.language.isoenen
dc.relation.urlhttp://content.nejm.org/cgi/content/abstract/343/24/1765en
dc.subject.meshAge of Onseten
dc.subject.meshCase-Control Studiesen
dc.subject.meshEnvironmenten
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshParkinson Diseaseen
dc.subject.meshPedigreeen
dc.titleFamilial aggregation of Parkinson's disease in Icelanden
dc.typeArticleen
dc.contributor.departmentNational University Hospital, Reykjavik, Icelanden
dc.identifier.journalNew England journal of medicineen

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