The association between parathyroid hormone, vitamin D and bone mineral density in 70-year-old Icelandic women.

2.50
Hdl Handle:
http://hdl.handle.net/2336/34192
Title:
The association between parathyroid hormone, vitamin D and bone mineral density in 70-year-old Icelandic women.
Authors:
Sigurdsson, G; Franzson, L; Steingrimsdottir, L; Sigvaldason, H
Citation:
Osteoporos Int. 2000, 11(12):1031-5
Issue Date:
1-Dec-2000
Abstract:
Parathyroid hormone (PTH) may be an important determinant of cortical bone remodeling in the elderly. Vitamin D status is one of the determining factors in this relationship. The aim of this study was to quantify the relationship between serum PTH, vitamin D and bone mineral density (BMD) in elderly women in Reykjavik (64 degrees N), where daily intake of cod liver oil is common and mean calcium intake is high. In PTH correlated inversely with 25(OH)D (r = -0.26, p<0.0 1). In multivariate analysis PTH correlated inversely with whole body BMD (mostly cortical bone) (R2 = 2.2%, p = 0.04) but not with the lumbar spine BMD, reflecting more cancellous bone. No association was found between 25(OH)D levels and BMD at any site in univariate or multivariate analysis. Osteocalcin, a measure of bone turnover, was negatively associated with BMD and this association remained significant when corrected for PTH levels. In summary, in this fairly vitamin D replete population with high calcium intake, PTH was negatively associated with total body BMD. We infer that suppression of PTH may reduce cortical bone loss, but other factors are likely to contribute to age-related bone remodeling and osteoporosis.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.springerlink.com/content/9lcft3fqt8qenw7x

Full metadata record

DC FieldValue Language
dc.contributor.authorSigurdsson, G-
dc.contributor.authorFranzson, L-
dc.contributor.authorSteingrimsdottir, L-
dc.contributor.authorSigvaldason, H-
dc.date.accessioned2008-08-05T11:56:31Z-
dc.date.available2008-08-05T11:56:31Z-
dc.date.issued2000-12-01-
dc.date.submitted2008-08-05-
dc.identifier.citationOsteoporos Int. 2000, 11(12):1031-5en
dc.identifier.issn0937-941X-
dc.identifier.pmid11256894-
dc.identifier.doi10.1007/s001980070024-
dc.identifier.urihttp://hdl.handle.net/2336/34192-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractParathyroid hormone (PTH) may be an important determinant of cortical bone remodeling in the elderly. Vitamin D status is one of the determining factors in this relationship. The aim of this study was to quantify the relationship between serum PTH, vitamin D and bone mineral density (BMD) in elderly women in Reykjavik (64 degrees N), where daily intake of cod liver oil is common and mean calcium intake is high. In PTH correlated inversely with 25(OH)D (r = -0.26, p<0.0 1). In multivariate analysis PTH correlated inversely with whole body BMD (mostly cortical bone) (R2 = 2.2%, p = 0.04) but not with the lumbar spine BMD, reflecting more cancellous bone. No association was found between 25(OH)D levels and BMD at any site in univariate or multivariate analysis. Osteocalcin, a measure of bone turnover, was negatively associated with BMD and this association remained significant when corrected for PTH levels. In summary, in this fairly vitamin D replete population with high calcium intake, PTH was negatively associated with total body BMD. We infer that suppression of PTH may reduce cortical bone loss, but other factors are likely to contribute to age-related bone remodeling and osteoporosis.en
dc.language.isoenen
dc.relation.urlhttp://www.springerlink.com/content/9lcft3fqt8qenw7xen
dc.subject.meshAbsorptiometry, Photonen
dc.subject.meshAgeden
dc.subject.meshAnalysis of Varianceen
dc.subject.meshBone Densityen
dc.subject.meshBone Remodelingen
dc.subject.meshCalciumen
dc.subject.meshCod Liver Oilen
dc.subject.meshCollagenen
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshOsteocalcinen
dc.subject.meshParathyroid Hormoneen
dc.subject.meshVitamin Den
dc.titleThe association between parathyroid hormone, vitamin D and bone mineral density in 70-year-old Icelandic women.en
dc.typeArticleen
dc.contributor.departmentDepartment of Internal Medicine, University Hospital, Fossvogur, Reykjavik, Iceland. maria@shr.isen
dc.identifier.journalOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USAen
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