Elevation of only one rheumatoid factor isotype is not associated with increased prevalence of rheumatoid arthritis--a population based study

2.50
Hdl Handle:
http://hdl.handle.net/2336/34292
Title:
Elevation of only one rheumatoid factor isotype is not associated with increased prevalence of rheumatoid arthritis--a population based study
Authors:
Jonsson, T; Thorsteinsson, J; Valdimarsson, H
Citation:
Scand. J. Rheumatol. 2000, 29(3):190-1
Issue Date:
1-Jun-2000
Abstract:
OBJECTIVE: To analyse the relationship between different rheumatoid factor (RF) isotype patterns and the prevalence of RA. METHODS: Serum samples, collected between 1973 and 1983 from nearly 14,000 randomly selected individuals, were screened for elevation of RF. In 1987, 173 RF positive and 156 matched RF negative participants were evaluated clinically. RESULTS: Participants with elevation of only one RF isotype, most commonly IgM, did not have significantly higher prevalence of RA than the RF negative controls. Of the 17 RF positive individuals who were diagnosed with RA, 14 (82%) had a combined elevation of IgM and IgA RF. CONCLUSION: In contrast to a combined elevation of IgM and IgA RF, elevation of only one RF isotype may not be a significant risk factor for the development of RA.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
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Full metadata record

DC FieldValue Language
dc.contributor.authorJonsson, T-
dc.contributor.authorThorsteinsson, J-
dc.contributor.authorValdimarsson, H-
dc.date.accessioned2008-08-05T14:08:23Z-
dc.date.available2008-08-05T14:08:23Z-
dc.date.issued2000-06-01-
dc.date.submitted2008-08-05-
dc.identifier.citationScand. J. Rheumatol. 2000, 29(3):190-1en
dc.identifier.issn0300-9742-
dc.identifier.pmid10898074-
dc.identifier.doi10.1080/030097400750002094-
dc.identifier.urihttp://hdl.handle.net/2336/34292-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVE: To analyse the relationship between different rheumatoid factor (RF) isotype patterns and the prevalence of RA. METHODS: Serum samples, collected between 1973 and 1983 from nearly 14,000 randomly selected individuals, were screened for elevation of RF. In 1987, 173 RF positive and 156 matched RF negative participants were evaluated clinically. RESULTS: Participants with elevation of only one RF isotype, most commonly IgM, did not have significantly higher prevalence of RA than the RF negative controls. Of the 17 RF positive individuals who were diagnosed with RA, 14 (82%) had a combined elevation of IgM and IgA RF. CONCLUSION: In contrast to a combined elevation of IgM and IgA RF, elevation of only one RF isotype may not be a significant risk factor for the development of RA.en
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.relation.urlhttp://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=4347879&site=ehost-liveen
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshArthritis, Rheumatoiden
dc.subject.meshEnzyme-Linked Immunosorbent Assayen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshImmunoglobulin Aen
dc.subject.meshImmunoglobulin Isotypesen
dc.subject.meshImmunoglobulin Men
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshPrevalenceen
dc.subject.meshProspective Studiesen
dc.subject.meshRheumatoid Factoren
dc.titleElevation of only one rheumatoid factor isotype is not associated with increased prevalence of rheumatoid arthritis--a population based studyen
dc.typeArticleen
dc.contributor.departmentDepartment of Immunology, National University Hospital, Landspítalinn Reykjavík, Iceland.en
dc.identifier.journalScandinavian journal of rheumatologyen

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