Risk of epilepsy in long-term survivors of surgery for aneurysmal subarachnoid hemorrhage: a population-based study in Iceland.

2.50
Hdl Handle:
http://hdl.handle.net/2336/34412
Title:
Risk of epilepsy in long-term survivors of surgery for aneurysmal subarachnoid hemorrhage: a population-based study in Iceland.
Authors:
Olafsson, E; Gudmundsson, G; Hauser, W A
Citation:
Epilepsia. 2000, 41(9):1201-5
Issue Date:
1-Sep-2000
Abstract:
PURPOSE: Epilepsy is known to result from aneurysmal subarachnoid hemorrhage (SAH). There are no population-based estimates of the absolute risk or the duration for which this risk is elevated. We have conducted a population-based study in Iceland of the risk of epilepsy after a ruptured cerebral aneurysm to address these questions. METHODS: The index patients are all of the patients who presented with SAH caused by ruptured cerebral aneurysm in Iceland during an 11-year period (1958 to 1968) and survived more than 6 months. We determined the number of index patients who developed epilepsy. The observed number of cases of epilepsy was compared with that expected based on the incidence of epilepsy in Iceland. RESULTS: There were 44 index patients; 11 (25%) developed epilepsy, all within 4 years of the insult. Seven (70%) of 10 patients with acute symptomatic seizures (defined as seizures during the first 2 weeks after the hemorrhage) developed epilepsy (relative risk, 7.0; 95% confidence interval, 2.3-21.6). Epilepsy was more frequent in patients with severe neurological residua (48%) compared with patients without (20%) (relative risk, 2.5; 95% confidence interval, 0.9-6.3). CONCLUSIONS: The risk for epilepsy among survivors of SAH caused by ruptured cerebral aneurysm is substantially increased. Both acute symptomatic seizure and persistent neurological impairment are associated with a further increase in the risk of epilepsy.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://ejournals.ebsco.com/direct.asp?ArticleID=46139A9EBC9DEDFE69DC

Full metadata record

DC FieldValue Language
dc.contributor.authorOlafsson, E-
dc.contributor.authorGudmundsson, G-
dc.contributor.authorHauser, W A-
dc.date.accessioned2008-08-05T16:12:17Z-
dc.date.available2008-08-05T16:12:17Z-
dc.date.issued2000-09-01-
dc.date.submitted2008-08-05-
dc.identifier.citationEpilepsia. 2000, 41(9):1201-5en
dc.identifier.issn0013-9580-
dc.identifier.pmid10999560-
dc.identifier.urihttp://hdl.handle.net/2336/34412-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPURPOSE: Epilepsy is known to result from aneurysmal subarachnoid hemorrhage (SAH). There are no population-based estimates of the absolute risk or the duration for which this risk is elevated. We have conducted a population-based study in Iceland of the risk of epilepsy after a ruptured cerebral aneurysm to address these questions. METHODS: The index patients are all of the patients who presented with SAH caused by ruptured cerebral aneurysm in Iceland during an 11-year period (1958 to 1968) and survived more than 6 months. We determined the number of index patients who developed epilepsy. The observed number of cases of epilepsy was compared with that expected based on the incidence of epilepsy in Iceland. RESULTS: There were 44 index patients; 11 (25%) developed epilepsy, all within 4 years of the insult. Seven (70%) of 10 patients with acute symptomatic seizures (defined as seizures during the first 2 weeks after the hemorrhage) developed epilepsy (relative risk, 7.0; 95% confidence interval, 2.3-21.6). Epilepsy was more frequent in patients with severe neurological residua (48%) compared with patients without (20%) (relative risk, 2.5; 95% confidence interval, 0.9-6.3). CONCLUSIONS: The risk for epilepsy among survivors of SAH caused by ruptured cerebral aneurysm is substantially increased. Both acute symptomatic seizure and persistent neurological impairment are associated with a further increase in the risk of epilepsy.en
dc.language.isoenen
dc.publisherBlackwell Scienceen
dc.relation.urlhttp://ejournals.ebsco.com/direct.asp?ArticleID=46139A9EBC9DEDFE69DCen
dc.subject.meshEpilepsyen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshIntracranial Aneurysmen
dc.subject.meshPostoperative Complicationsen
dc.subject.meshRuptureen
dc.subject.meshSubarachnoid Hemorrhageen
dc.titleRisk of epilepsy in long-term survivors of surgery for aneurysmal subarachnoid hemorrhage: a population-based study in Iceland.en
dc.typeArticleen
dc.contributor.departmentDepartment of Neurology, National University Hospital Landspitalinn, Reykjavik, Iceland. eliasol@rsp.isen
dc.identifier.journalEpilepsiaen

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