Different beta-casein fractions in Icelandic versus Scandinavian cow's milk may influence diabetogenicity of cow's milk in infancy and explain low incidence of insulin-dependent diabetes mellitus in Iceland.

2.50
Hdl Handle:
http://hdl.handle.net/2336/34472
Title:
Different beta-casein fractions in Icelandic versus Scandinavian cow's milk may influence diabetogenicity of cow's milk in infancy and explain low incidence of insulin-dependent diabetes mellitus in Iceland.
Authors:
Thorsdottir, I; Birgisdottir, B E; Johannsdottir, I M; Harris, D P; Hill, J; Steingrimsdottir, L; Thorsson, A V
Citation:
Pediatrics 2000, 106(4):719-24
Issue Date:
1-Oct-2000
Abstract:
OBJECTIVES: To compare children with insulin-dependent diabetes mellitus (IDDM) with controls in Iceland regarding their consumption of cow's milk in infancy, and to investigate the beta-casein fractions in Scandinavian and Icelandic cow's milk. The A1 variant of beta-casein has been shown to be diabetogenic in animal studies, and suggestions have been made that the B variant of beta-casein acts similarly. Differences in the relative proportions of beta-casein fractions might explain the lower incidence of IDDM in Iceland than in Scandinavia. METHODS: A retrospective case-control study on IDDM patients and matching controls was performed in Iceland to compare their diets in infancy. Fifty-five children with IDDM born in Iceland over a 16-year period and randomly collected controls (n = 165) were recruited to the study. Mothers of the children answered questions on breastfeeding habits and on when cow's milk products were introduced. Samples of cow's milk from randomly selected milk batches from the largest consumption areas in Iceland and Scandinavia were collected. The milk samples were freeze-dried and their beta-casein fractions were analyzed using capillary electrophoresis. RESULTS: No significant difference was found between IDDM patients and controls in the frequency and duration of breastfeeding or the first introduction of cow's milk products. The analyses of milk samples showed that the percentage of the A1 and B variants of beta-casein in Icelandic milk was significantly lower than in the milk from the Scandinavian countries. CONCLUSIONS: Cow's milk consumption in infancy is not related to IDDM in Iceland. The lower fraction of A1 and B beta-caseins in Icelandic cow's milk may explain why there is a lower incidence of IDDM in Iceland than in Scandinavia.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://pediatrics.aappublications.org/cgi/content/abstract/106/4/719

Full metadata record

DC FieldValue Language
dc.contributor.authorThorsdottir, I-
dc.contributor.authorBirgisdottir, B E-
dc.contributor.authorJohannsdottir, I M-
dc.contributor.authorHarris, D P-
dc.contributor.authorHill, J-
dc.contributor.authorSteingrimsdottir, L-
dc.contributor.authorThorsson, A V-
dc.date.accessioned2008-08-06T09:07:19Z-
dc.date.available2008-08-06T09:07:19Z-
dc.date.issued2000-10-01-
dc.date.submitted2008-08-06-
dc.identifier.citationPediatrics 2000, 106(4):719-24en
dc.identifier.issn0031-4005-
dc.identifier.pmid11015514-
dc.identifier.urihttp://hdl.handle.net/2336/34472-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVES: To compare children with insulin-dependent diabetes mellitus (IDDM) with controls in Iceland regarding their consumption of cow's milk in infancy, and to investigate the beta-casein fractions in Scandinavian and Icelandic cow's milk. The A1 variant of beta-casein has been shown to be diabetogenic in animal studies, and suggestions have been made that the B variant of beta-casein acts similarly. Differences in the relative proportions of beta-casein fractions might explain the lower incidence of IDDM in Iceland than in Scandinavia. METHODS: A retrospective case-control study on IDDM patients and matching controls was performed in Iceland to compare their diets in infancy. Fifty-five children with IDDM born in Iceland over a 16-year period and randomly collected controls (n = 165) were recruited to the study. Mothers of the children answered questions on breastfeeding habits and on when cow's milk products were introduced. Samples of cow's milk from randomly selected milk batches from the largest consumption areas in Iceland and Scandinavia were collected. The milk samples were freeze-dried and their beta-casein fractions were analyzed using capillary electrophoresis. RESULTS: No significant difference was found between IDDM patients and controls in the frequency and duration of breastfeeding or the first introduction of cow's milk products. The analyses of milk samples showed that the percentage of the A1 and B variants of beta-casein in Icelandic milk was significantly lower than in the milk from the Scandinavian countries. CONCLUSIONS: Cow's milk consumption in infancy is not related to IDDM in Iceland. The lower fraction of A1 and B beta-caseins in Icelandic cow's milk may explain why there is a lower incidence of IDDM in Iceland than in Scandinavia.en
dc.language.isoenen
dc.publisherAmerican Academy of Pediatricsen
dc.relation.urlhttp://pediatrics.aappublications.org/cgi/content/abstract/106/4/719en
dc.subject.meshAdolescenten
dc.subject.meshAnimalsen
dc.subject.meshBreast Feedingen
dc.subject.meshCase-Control Studiesen
dc.subject.meshCaseinsen
dc.subject.meshChilden
dc.subject.meshChild, Preschoolen
dc.subject.meshDiabetes Mellitus, Type 1en
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshIncidenceen
dc.subject.meshInfanten
dc.subject.meshMilken
dc.subject.meshRetrospective Studiesen
dc.subject.meshScandinaviaen
dc.titleDifferent beta-casein fractions in Icelandic versus Scandinavian cow's milk may influence diabetogenicity of cow's milk in infancy and explain low incidence of insulin-dependent diabetes mellitus in Iceland.en
dc.typeArticleen
dc.identifier.eissn1098-4275-
dc.contributor.departmentUnit for Nutrition Research, National University Hospital, Department of Food Science, Reykjavik, Iceland. ingathor@rsp.isen
dc.identifier.journalPediatricsen

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