Birth weight and risk for childhood leukemia in Denmark, Sweden, Norway, and Iceland

2.50
Hdl Handle:
http://hdl.handle.net/2336/3511
Title:
Birth weight and risk for childhood leukemia in Denmark, Sweden, Norway, and Iceland
Authors:
Hjalgrim, Lisa Lyngsie; Rostgaard, Klaus; Hjalgrim, Henrik; Westergaard, Tine; Thomassen, Harald; Forestier, Erik; Gustafsson, Göran; Kristinsson, Jon; Melbye, Mads; Schmiegelow, Kjeld
Citation:
J. Natl. Cancer Inst. 2004, 96(20):1549-56
Issue Date:
2004
Abstract:
BACKGROUND: Compelling evidence suggests that childhood leukemia often originates in utero. Birth weight is one of the few pregnancy-related risk factors that has been associated with leukemia risk, but the association has remained poorly characterized. We conducted a population-based case-control study in Denmark, Sweden, Norway, and Iceland to investigate the association between birth weight (and other birth characteristics) and the risk of childhood leukemia. METHODS: Overall, 1905 children (aged 0-14 years) with acute lymphoblastic leukemia (ALL) and 299 children with acute myeloid leukemia (AML) diagnosed between January 1, 1984, and December 31, 1999, were identified in the Nordic Society of Paediatric Haematology and Oncology acute leukemia database. Each case patient was matched to five population control subjects (n = 10745) on nationality, age, and sex. All live-born siblings of case patients (n = 3812) and control subjects (n = 17,937) were also identified in population registers. Information on birth weight and gestational age at birth was ascertained from the national Medical Birth Registers. The association between various birth characteristics and leukemia risk was assessed by conditional logistic regression. All statistical tests were two-sided. RESULTS: Risk of ALL overall was statistically significantly associated with birth weight (odds ratio [OR] = 1.26 per 1-kg increase in birth weight, 95% confidence interval [CI] = 1.13 to 1.41). The association was similar for B- and T-lineage ALL and across all diagnostic ages (0-14 years). However, children with ALL did not weigh more at birth than their siblings. Statistically significantly reduced risks of B-precursor ALL were observed with increasing position in the birth order (OR = 0.90 per position increase, 95% CI = 0.84 to 0.96) and increasing gestational age (OR = 0.87 per 2-week increase in gestational age, 95% CI = 0.81 to 0.94). Risk of AML did not vary monotonically with birth weight, and low birth weight (<1500 g [i.e., 3.3 pounds]) was associated with the highest risk. CONCLUSION: Our results are compatible with the hypothesis that a high birth weight is associated with an increased risk of ALL.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://jnci.oxfordjournals.org/cgi/content/abstract/jnci;96/20/1549

Full metadata record

DC FieldValue Language
dc.contributor.authorHjalgrim, Lisa Lyngsie-
dc.contributor.authorRostgaard, Klaus-
dc.contributor.authorHjalgrim, Henrik-
dc.contributor.authorWestergaard, Tine-
dc.contributor.authorThomassen, Harald-
dc.contributor.authorForestier, Erik-
dc.contributor.authorGustafsson, Göran-
dc.contributor.authorKristinsson, Jon-
dc.contributor.authorMelbye, Mads-
dc.contributor.authorSchmiegelow, Kjeld-
dc.date.accessioned2006-07-20T13:25:19Z-
dc.date.available2006-07-20T13:25:19Z-
dc.date.issued2004-
dc.identifier.citationJ. Natl. Cancer Inst. 2004, 96(20):1549-56en
dc.identifier.issn1460-2105-
dc.identifier.pmid15494605-
dc.identifier.doi10.1093/jnci/djh287-
dc.identifier.urihttp://hdl.handle.net/2336/3511-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: Compelling evidence suggests that childhood leukemia often originates in utero. Birth weight is one of the few pregnancy-related risk factors that has been associated with leukemia risk, but the association has remained poorly characterized. We conducted a population-based case-control study in Denmark, Sweden, Norway, and Iceland to investigate the association between birth weight (and other birth characteristics) and the risk of childhood leukemia. METHODS: Overall, 1905 children (aged 0-14 years) with acute lymphoblastic leukemia (ALL) and 299 children with acute myeloid leukemia (AML) diagnosed between January 1, 1984, and December 31, 1999, were identified in the Nordic Society of Paediatric Haematology and Oncology acute leukemia database. Each case patient was matched to five population control subjects (n = 10745) on nationality, age, and sex. All live-born siblings of case patients (n = 3812) and control subjects (n = 17,937) were also identified in population registers. Information on birth weight and gestational age at birth was ascertained from the national Medical Birth Registers. The association between various birth characteristics and leukemia risk was assessed by conditional logistic regression. All statistical tests were two-sided. RESULTS: Risk of ALL overall was statistically significantly associated with birth weight (odds ratio [OR] = 1.26 per 1-kg increase in birth weight, 95% confidence interval [CI] = 1.13 to 1.41). The association was similar for B- and T-lineage ALL and across all diagnostic ages (0-14 years). However, children with ALL did not weigh more at birth than their siblings. Statistically significantly reduced risks of B-precursor ALL were observed with increasing position in the birth order (OR = 0.90 per position increase, 95% CI = 0.84 to 0.96) and increasing gestational age (OR = 0.87 per 2-week increase in gestational age, 95% CI = 0.81 to 0.94). Risk of AML did not vary monotonically with birth weight, and low birth weight (<1500 g [i.e., 3.3 pounds]) was associated with the highest risk. CONCLUSION: Our results are compatible with the hypothesis that a high birth weight is associated with an increased risk of ALL.en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urlhttp://jnci.oxfordjournals.org/cgi/content/abstract/jnci;96/20/1549en
dc.subjectAdolescenten
dc.subjectBirth Orderen
dc.subjectBirth Weighten
dc.subjectCase-Control Studiesen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectDenmarken
dc.subjectGestational Ageen
dc.subjectIcelanden
dc.subjectInfanten
dc.subjectInfant, Newbornen
dc.subjectLeukemia, Lymphocytic, Acute, L1en
dc.subjectLeukemia, Myelocytic, Acuteen
dc.subjectNorwayen
dc.subjectResearch Support, Non-U.S. Gov'ten
dc.subjectRisk Assessmenten
dc.subjectRisk Factorsen
dc.subjectSwedenen
dc.titleBirth weight and risk for childhood leukemia in Denmark, Sweden, Norway, and Icelanden
dc.typeArticleen
dc.identifier.journalJournal of the National Cancer Instituteen
dc.format.digYES-

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