2.50
Hdl Handle:
http://hdl.handle.net/2336/3528
Title:
ADHD as a risk factor for incident unprovoked seizures and epilepsy in children
Authors:
Hesdorffer, Dale C; Ludvigsson, Petur; Olafsson, Elias; Gudmundsson, Gunnar; Kjartansson, Olafur; Hauser, W Allen
Citation:
Arch. Gen. Psychiatry 2004, 61(7):731-6
Issue Date:
2004
Abstract:
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) occurs more frequently than expected in prevalent cohorts with epilepsy. The association has been attributed to the epilepsy or its treatment, although it is impossible to determine in previous studies which condition occurs first. OBJECTIVES: To conduct a population-based case-control study of all newly diagnosed unprovoked seizures among Icelandic children younger than 16 years to address the question of time order. DESIGN: Children with seizures were matched to the next 2 same-sex births from the population registry. The Diagnostic Interview Schedule for Children was used to make a DSM-IV diagnosis of ADHD in a standardized fashion among cases and controls aged 3 to 16 years. RESULTS: A history of ADHD was 2.5-fold more common among children with newly diagnosed seizures than among control subjects (95% confidence interval [CI], 1.1-5.5). The association was restricted to ADHD predominantly inattentive type (odds ratio [OR], 3.7; 95% CI, 1.1-12.8), not ADHD predominantly hyperactive-impulsive type (OR, 1.8; 95% CI, 0.6-5.7) or ADHD combined type (OR, 2.5; 95% CI, 0.3-18.3). Seizure type, etiology, sex, or seizure frequency at diagnosis (1 or >1) did not affect findings. CONCLUSION: Attention-deficit/hyperactivity disorder occurs more often than expected before unprovoked seizures, suggesting a common antecedent for both conditions.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://archpsyc.ama-assn.org/cgi/content/full/61/7/731

Full metadata record

DC FieldValue Language
dc.contributor.authorHesdorffer, Dale C-
dc.contributor.authorLudvigsson, Petur-
dc.contributor.authorOlafsson, Elias-
dc.contributor.authorGudmundsson, Gunnar-
dc.contributor.authorKjartansson, Olafur-
dc.contributor.authorHauser, W Allen-
dc.date.accessioned2006-07-21T12:57:06Z-
dc.date.available2006-07-21T12:57:06Z-
dc.date.issued2004-
dc.identifier.citationArch. Gen. Psychiatry 2004, 61(7):731-6en
dc.identifier.issn0003-990X-
dc.identifier.pmid15237085-
dc.identifier.doi10.1001/archpsyc.61.7.731-
dc.identifier.urihttp://hdl.handle.net/2336/3528-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) occurs more frequently than expected in prevalent cohorts with epilepsy. The association has been attributed to the epilepsy or its treatment, although it is impossible to determine in previous studies which condition occurs first. OBJECTIVES: To conduct a population-based case-control study of all newly diagnosed unprovoked seizures among Icelandic children younger than 16 years to address the question of time order. DESIGN: Children with seizures were matched to the next 2 same-sex births from the population registry. The Diagnostic Interview Schedule for Children was used to make a DSM-IV diagnosis of ADHD in a standardized fashion among cases and controls aged 3 to 16 years. RESULTS: A history of ADHD was 2.5-fold more common among children with newly diagnosed seizures than among control subjects (95% confidence interval [CI], 1.1-5.5). The association was restricted to ADHD predominantly inattentive type (odds ratio [OR], 3.7; 95% CI, 1.1-12.8), not ADHD predominantly hyperactive-impulsive type (OR, 1.8; 95% CI, 0.6-5.7) or ADHD combined type (OR, 2.5; 95% CI, 0.3-18.3). Seizure type, etiology, sex, or seizure frequency at diagnosis (1 or >1) did not affect findings. CONCLUSION: Attention-deficit/hyperactivity disorder occurs more often than expected before unprovoked seizures, suggesting a common antecedent for both conditions.en
dc.language.isoenen
dc.publisherAmerican Medical Assn.en
dc.relation.urlhttp://archpsyc.ama-assn.org/cgi/content/full/61/7/731en
dc.subjectAttention Deficit Disorder with Hyperactivityen
dc.subjectCase-Control Studiesen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectComorbidityen
dc.subjectComparative Studyen
dc.subjectElectroencephalographyen
dc.subjectEpilepsyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectIceland/epidemiologyen
dc.subjectMagnetic Resonance Imagingen
dc.subjectMaleen
dc.subjectPopulation Surveillanceen
dc.subjectPrevalenceen
dc.subjectPsychiatric Status Rating Scalesen
dc.subjectResearch Support, U.S. Gov't, P.H.S.en
dc.subjectRisk Factorsen
dc.subjectSeizuresen
dc.subjectTomography, X-Ray Computeden
dc.titleADHD as a risk factor for incident unprovoked seizures and epilepsy in childrenen
dc.typeArticleen
dc.identifier.journalArchives of general psychiatryen
dc.format.digYES-

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