Lymphoid tumours of the ocular adnexa: a morphologic and genotypic study of 15 cases

2.50
Hdl Handle:
http://hdl.handle.net/2336/35775
Title:
Lymphoid tumours of the ocular adnexa: a morphologic and genotypic study of 15 cases
Authors:
Sigurdardottir, Margret; Sigurdsson, Haraldur; Barkardottir, Rosa Bjork; Kristjansdottir, Sigrun; Agnarsson, Bjarni A
Citation:
Acta Ophthalmol Scand. 2003, 81(3):299-303
Issue Date:
1-Jun-2003
Abstract:
PURPOSE: To examine all lymphoproliferative lesions of the ocular adnexa diagnosed in Iceland during 1983-2000 and to determine whether polymerase chain reaction (PCR) methods to determine clonality are helpful in characterizing these lesions. METHODS: All patients diagnosed with lymphoproliferative lesions in the ocular adnexa in the years 1983-2000 were included in the study. Polymerase chain reaction studies for clonality were performed on these lesions. RESULTS: Fifteen cases were identified. Seven were classified as inflammatory pseudotumour, one as lymphoid hyperplasia, four as atypical lymphoid hyperplasia and three as lymphoma. Of 12 cases examined by PCR, three were monoclonal for B-cells (one lymphoma, one inflammatory pseudotumour and one atypical lymphoid hyperplasia) while the remaining lesions (including two lymphomas) appeared polyclonal. CONCLUSION: The results of this study suggest that analysis of clonality by PCR methods may be of limited use in classifying lymphoproliferative lesions of the ocular adnexa as benign or malignant. These results underscore the importance of using several techniques when determining clonality.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1034/j.1600-0420.2003.00067.x

Full metadata record

DC FieldValue Language
dc.contributor.authorSigurdardottir, Margret-
dc.contributor.authorSigurdsson, Haraldur-
dc.contributor.authorBarkardottir, Rosa Bjork-
dc.contributor.authorKristjansdottir, Sigrun-
dc.contributor.authorAgnarsson, Bjarni A-
dc.date.accessioned2008-08-18T13:30:23Z-
dc.date.available2008-08-18T13:30:23Z-
dc.date.issued2003-06-01-
dc.date.submitted2008-08-18-
dc.identifier.citationActa Ophthalmol Scand. 2003, 81(3):299-303en
dc.identifier.issn1395-3907-
dc.identifier.pmid12780412-
dc.identifier.doi10.1034/j.1600-0420.2003.00067.x-
dc.identifier.urihttp://hdl.handle.net/2336/35775-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractPURPOSE: To examine all lymphoproliferative lesions of the ocular adnexa diagnosed in Iceland during 1983-2000 and to determine whether polymerase chain reaction (PCR) methods to determine clonality are helpful in characterizing these lesions. METHODS: All patients diagnosed with lymphoproliferative lesions in the ocular adnexa in the years 1983-2000 were included in the study. Polymerase chain reaction studies for clonality were performed on these lesions. RESULTS: Fifteen cases were identified. Seven were classified as inflammatory pseudotumour, one as lymphoid hyperplasia, four as atypical lymphoid hyperplasia and three as lymphoma. Of 12 cases examined by PCR, three were monoclonal for B-cells (one lymphoma, one inflammatory pseudotumour and one atypical lymphoid hyperplasia) while the remaining lesions (including two lymphomas) appeared polyclonal. CONCLUSION: The results of this study suggest that analysis of clonality by PCR methods may be of limited use in classifying lymphoproliferative lesions of the ocular adnexa as benign or malignant. These results underscore the importance of using several techniques when determining clonality.en
dc.language.isoenen
dc.publisherBlackwellen
dc.relation.urlhttp://dx.doi.org/10.1034/j.1600-0420.2003.00067.xen
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshDNA, Neoplasmen
dc.subject.meshFemaleen
dc.subject.meshGenotypeen
dc.subject.meshGranuloma, Plasma Cell, Orbitalen
dc.subject.meshHumansen
dc.subject.meshHyperplasiaen
dc.subject.meshIcelanden
dc.subject.meshImmunoenzyme Techniquesen
dc.subject.meshLymphomaen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshOrbital Neoplasmsen
dc.subject.meshPolymerase Chain Reactionen
dc.titleLymphoid tumours of the ocular adnexa: a morphologic and genotypic study of 15 casesen
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, University Hospital, Reykjavik, Iceland.en
dc.identifier.journalActa ophthalmologica Scandinavicaen

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