Restoration of muscle volume and shape induced by electrical stimulation of denervated degenerated muscles: qualitative and quantitative measurement of changes in rectus femoris using computer tomography and image segmentation.

2.50
Hdl Handle:
http://hdl.handle.net/2336/41754
Title:
Restoration of muscle volume and shape induced by electrical stimulation of denervated degenerated muscles: qualitative and quantitative measurement of changes in rectus femoris using computer tomography and image segmentation.
Authors:
Gargiulo, Paolo; Vatnsdal, Brynjar; Ingvarsson, Pall; Knutsdottir, Sigrun; Gudmundsdottir, Vilborg; Yngvason, Stefan; Helgason, Thordur
Citation:
Artif Organs 2008, 32(8):609-13
Issue Date:
1-Aug-2008
Abstract:
This study demonstrates in a novel way how volume and shape are restored to denervated degenerated muscles due to a special pattern of electrical stimulation. To this purpose, Spiral Computer Tomography (CT) and special image processing tools were used to develop a method to isolate the rectus femoris from other muscle bellies in the thigh and monitor growth and morphology changes very accurately. During 4 years of electrical stimulation, three-dimensional (3D) reconstructions of the rectus femoris muscles from patients with long-term flaccid paraplegia were made at different points in time. The growth of the muscle and its changes through the time period are seen in the 3D representation and are measured quantitatively. Furthermore, changes in shape are compared with respect to healthy muscles in order to estimate the degree of restoration. The results clearly show a slow but continuing muscle growth induced by electrical stimulation; the increase of volume is accompanied by the return of a quasi-normal muscle shape. This technique allows a unique way of monitoring which provides qualitative and quantitative information on the denervated degenerated muscle behavior otherwise hidden.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1111/j.1525-1594.2008.00610.x

Full metadata record

DC FieldValue Language
dc.contributor.authorGargiulo, Paolo-
dc.contributor.authorVatnsdal, Brynjar-
dc.contributor.authorIngvarsson, Pall-
dc.contributor.authorKnutsdottir, Sigrun-
dc.contributor.authorGudmundsdottir, Vilborg-
dc.contributor.authorYngvason, Stefan-
dc.contributor.authorHelgason, Thordur-
dc.date.accessioned2008-12-03T09:32:14Z-
dc.date.available2008-12-03T09:32:14Z-
dc.date.issued2008-08-01-
dc.date.submitted2008-12-03-
dc.identifier.citationArtif Organs 2008, 32(8):609-13en
dc.identifier.issn0160-564X-
dc.identifier.pmid18782130-
dc.identifier.doi10.1111/j.1525-1594.2008.00610.x-
dc.identifier.urihttp://hdl.handle.net/2336/41754-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractThis study demonstrates in a novel way how volume and shape are restored to denervated degenerated muscles due to a special pattern of electrical stimulation. To this purpose, Spiral Computer Tomography (CT) and special image processing tools were used to develop a method to isolate the rectus femoris from other muscle bellies in the thigh and monitor growth and morphology changes very accurately. During 4 years of electrical stimulation, three-dimensional (3D) reconstructions of the rectus femoris muscles from patients with long-term flaccid paraplegia were made at different points in time. The growth of the muscle and its changes through the time period are seen in the 3D representation and are measured quantitatively. Furthermore, changes in shape are compared with respect to healthy muscles in order to estimate the degree of restoration. The results clearly show a slow but continuing muscle growth induced by electrical stimulation; the increase of volume is accompanied by the return of a quasi-normal muscle shape. This technique allows a unique way of monitoring which provides qualitative and quantitative information on the denervated degenerated muscle behavior otherwise hidden.en
dc.language.isoenen
dc.publisherBlackwell Scienceen
dc.relation.urlhttp://dx.doi.org/10.1111/j.1525-1594.2008.00610.xen
dc.subject.meshAdulten
dc.subject.meshElectric Stimulation Therapyen
dc.subject.meshHumansen
dc.subject.meshImage Processing, Computer-Assisteden
dc.subject.meshImaging, Three-Dimensionalen
dc.subject.meshMaleen
dc.subject.meshMuscle Denervationen
dc.subject.meshMuscular Atrophyen
dc.subject.meshOrgan Sizeen
dc.subject.meshParaplegiaen
dc.subject.meshQuadriceps Muscleen
dc.subject.meshTime Factorsen
dc.subject.meshTomography, Spiral Computeden
dc.titleRestoration of muscle volume and shape induced by electrical stimulation of denervated degenerated muscles: qualitative and quantitative measurement of changes in rectus femoris using computer tomography and image segmentation.en
dc.typeArticleen
dc.identifier.eissn1525-1594-
dc.contributor.departmentDepartment of Research and Development, HTS, Rekykjavik, Iceland. paologar@landspitali.isen
dc.identifier.journalArtificial organsen

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