2.50
Hdl Handle:
http://hdl.handle.net/2336/42077
Title:
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer
Authors:
Kiemeney, Lambertus A; Thorlacius, Steinunn; Sulem, Patrick; Geller, Frank; Aben, Katja K H; Stacey, Simon N; Gudmundsson, Julius; Jakobsdottir, Margret; Bergthorsson, Jon T; Sigurdsson, Asgeir; Blondal, Thorarinn; Witjes, J Alfred; Vermeulen, Sita H; Hulsbergen-van de Kaa, Christina A; Swinkels, Dorine W; Ploeg, Martine; Cornel, Erik B; Vergunst, Henk; Thorgeirsson, Thorgeir E; Gudbjartsson, Daniel; Gudjonsson, Sigurjon A; Thorleifsson, Gudmar; Kristinsson, Kari T; Mouy, Magali; Snorradottir, Steinunn; Placidi, Donatella; Campagna, Marcello; Arici, Cecilia; Koppova, Kvetoslava; Gurzau, Eugene; Rudnai, Peter; Kellen, Eliane; Polidoro, Silvia; Guarrera, Simonetta; Sacerdote, Carlotta; Sanchez, Manuel; Saez, Berta; Valdivia, Gabriel; Ryk, Charlotta; de Verdier, Petra; Lindblom, Annika; Golka, Klaus; Bishop, D Timothy; Knowles, Margaret A; Nikulasson, Sigfus; Petursdottir, Vigdis; Jonsson, Eirikur; Geirsson, Gudmundur; Kristjansson, Baldvin; Mayordomo, Jose I; Steineck, Gunnar; Porru, Stefano; Buntinx, Frank; Zeegers, Maurice P; Fletcher, Tony; Kumar, Rajiv; Matullo, Giuseppe; Vineis, Paolo; Kiltie, Anne E; Gulcher, Jeffrey R; Thorsteinsdottir, Unnur; Kong, Augustine; Rafnar, Thorunn; Stefansson, Kari
Citation:
Nat. Genet. 2008, 40(11):1307-12
Issue Date:
1-Nov-2008
Abstract:
We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7)).
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1038/ng.229

Full metadata record

DC FieldValue Language
dc.contributor.authorKiemeney, Lambertus A-
dc.contributor.authorThorlacius, Steinunn-
dc.contributor.authorSulem, Patrick-
dc.contributor.authorGeller, Frank-
dc.contributor.authorAben, Katja K H-
dc.contributor.authorStacey, Simon N-
dc.contributor.authorGudmundsson, Julius-
dc.contributor.authorJakobsdottir, Margret-
dc.contributor.authorBergthorsson, Jon T-
dc.contributor.authorSigurdsson, Asgeir-
dc.contributor.authorBlondal, Thorarinn-
dc.contributor.authorWitjes, J Alfred-
dc.contributor.authorVermeulen, Sita H-
dc.contributor.authorHulsbergen-van de Kaa, Christina A-
dc.contributor.authorSwinkels, Dorine W-
dc.contributor.authorPloeg, Martine-
dc.contributor.authorCornel, Erik B-
dc.contributor.authorVergunst, Henk-
dc.contributor.authorThorgeirsson, Thorgeir E-
dc.contributor.authorGudbjartsson, Daniel-
dc.contributor.authorGudjonsson, Sigurjon A-
dc.contributor.authorThorleifsson, Gudmar-
dc.contributor.authorKristinsson, Kari T-
dc.contributor.authorMouy, Magali-
dc.contributor.authorSnorradottir, Steinunn-
dc.contributor.authorPlacidi, Donatella-
dc.contributor.authorCampagna, Marcello-
dc.contributor.authorArici, Cecilia-
dc.contributor.authorKoppova, Kvetoslava-
dc.contributor.authorGurzau, Eugene-
dc.contributor.authorRudnai, Peter-
dc.contributor.authorKellen, Eliane-
dc.contributor.authorPolidoro, Silvia-
dc.contributor.authorGuarrera, Simonetta-
dc.contributor.authorSacerdote, Carlotta-
dc.contributor.authorSanchez, Manuel-
dc.contributor.authorSaez, Berta-
dc.contributor.authorValdivia, Gabriel-
dc.contributor.authorRyk, Charlotta-
dc.contributor.authorde Verdier, Petra-
dc.contributor.authorLindblom, Annika-
dc.contributor.authorGolka, Klaus-
dc.contributor.authorBishop, D Timothy-
dc.contributor.authorKnowles, Margaret A-
dc.contributor.authorNikulasson, Sigfus-
dc.contributor.authorPetursdottir, Vigdis-
dc.contributor.authorJonsson, Eirikur-
dc.contributor.authorGeirsson, Gudmundur-
dc.contributor.authorKristjansson, Baldvin-
dc.contributor.authorMayordomo, Jose I-
dc.contributor.authorSteineck, Gunnar-
dc.contributor.authorPorru, Stefano-
dc.contributor.authorBuntinx, Frank-
dc.contributor.authorZeegers, Maurice P-
dc.contributor.authorFletcher, Tony-
dc.contributor.authorKumar, Rajiv-
dc.contributor.authorMatullo, Giuseppe-
dc.contributor.authorVineis, Paolo-
dc.contributor.authorKiltie, Anne E-
dc.contributor.authorGulcher, Jeffrey R-
dc.contributor.authorThorsteinsdottir, Unnur-
dc.contributor.authorKong, Augustine-
dc.contributor.authorRafnar, Thorunn-
dc.contributor.authorStefansson, Kari-
dc.date.accessioned2008-12-09T10:58:54Z-
dc.date.available2008-12-09T10:58:54Z-
dc.date.issued2008-11-01-
dc.date.submitted2008-12-09-
dc.identifier.citationNat. Genet. 2008, 40(11):1307-12en
dc.identifier.issn1061-4036-
dc.identifier.pmid18794855-
dc.identifier.doi10.1038/ng.229-
dc.identifier.urihttp://hdl.handle.net/2336/42077-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractWe conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 x 10(-12)). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7)).en
dc.language.isoenen
dc.publisherNature Pub. Co.en
dc.relation.urlhttp://dx.doi.org/10.1038/ng.229en
dc.subject.meshPubMed - in processen
dc.subject.meshUrinary Bladder Neoplasmsen
dc.titleSequence variant on 8q24 confers susceptibility to urinary bladder canceren
dc.typeArticleen
dc.identifier.eissn1546-1718-
dc.contributor.departmentDepartment of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.en
dc.identifier.journalNature geneticsen

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