Linking exposure to polychlorinated biphenyls with fatty fish consumption and reduced fetal growth among Danish pregnant women: a cause for concern?

2.50
Hdl Handle:
http://hdl.handle.net/2336/42088
Title:
Linking exposure to polychlorinated biphenyls with fatty fish consumption and reduced fetal growth among Danish pregnant women: a cause for concern?
Authors:
Halldorsson, T I; Thorsdottir, I; Meltzer, H M; Nielsen, F; Olsen, S F
Citation:
Am. J. Epidemiol. 2008, 168(8):958-65
Issue Date:
15-Oct-2008
Abstract:
In a selected group of women from the Danish National Birth Cohort, the authors investigated the association between intake of fatty fish and plasma concentrations of polychlorinated biphenyls (PCBs) on the one hand and the association between maternal PCB concentrations and fetal growth on the other. Of 70,183 women who filled in a food frequency questionnaire during 1996-2002, 100 nulliparous women aged 25-35 years with normal prepregnancy body mass index were selected according to their intake of fatty fish (low (0 meals/month, n = 34), medium (1-3 meals/month, n = 33), or high (> or = meals/month, n = 33)). Women with a high intake of fatty fish had 50% (95% confidence interval (CI): 31, 72) higher plasma PCB concentrations than women with low intake. Maternal plasma PCB concentrations were inversely associated with birth weight and placental weight. The adjusted mean difference between the 75th and 25th PCB percentiles was -155 g (95% CI: -291, -19) for birth weight and -81 g (95% CI: -135, -26) for placental weight. These results support previous findings from this cohort, where fatty fish intake was inversely associated with fetal growth. Dietary recommendations often encourage weekly consumption of fatty fish. These results suggest that potential exposure to PCBs should be carefully considered before recommending such intakes among women of childbearing age.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://aje.oxfordjournals.org/cgi/content/abstract/168/8/958

Full metadata record

DC FieldValue Language
dc.contributor.authorHalldorsson, T I-
dc.contributor.authorThorsdottir, I-
dc.contributor.authorMeltzer, H M-
dc.contributor.authorNielsen, F-
dc.contributor.authorOlsen, S F-
dc.date.accessioned2008-12-09T13:41:27Z-
dc.date.available2008-12-09T13:41:27Z-
dc.date.issued2008-10-15-
dc.date.submitted2008-12-09-
dc.identifier.citationAm. J. Epidemiol. 2008, 168(8):958-65en
dc.identifier.issn0002-9262-
dc.identifier.pmid18718897-
dc.identifier.doi10.1093/aje/kwn204-
dc.identifier.urihttp://hdl.handle.net/2336/42088-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractIn a selected group of women from the Danish National Birth Cohort, the authors investigated the association between intake of fatty fish and plasma concentrations of polychlorinated biphenyls (PCBs) on the one hand and the association between maternal PCB concentrations and fetal growth on the other. Of 70,183 women who filled in a food frequency questionnaire during 1996-2002, 100 nulliparous women aged 25-35 years with normal prepregnancy body mass index were selected according to their intake of fatty fish (low (0 meals/month, n = 34), medium (1-3 meals/month, n = 33), or high (> or = meals/month, n = 33)). Women with a high intake of fatty fish had 50% (95% confidence interval (CI): 31, 72) higher plasma PCB concentrations than women with low intake. Maternal plasma PCB concentrations were inversely associated with birth weight and placental weight. The adjusted mean difference between the 75th and 25th PCB percentiles was -155 g (95% CI: -291, -19) for birth weight and -81 g (95% CI: -135, -26) for placental weight. These results support previous findings from this cohort, where fatty fish intake was inversely associated with fetal growth. Dietary recommendations often encourage weekly consumption of fatty fish. These results suggest that potential exposure to PCBs should be carefully considered before recommending such intakes among women of childbearing age.en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urlhttp://aje.oxfordjournals.org/cgi/content/abstract/168/8/958en
dc.subject.meshAdulten
dc.subject.meshDenmarken
dc.subject.meshDietary Fatsen
dc.subject.meshEnvironmental Pollutantsen
dc.subject.meshFemaleen
dc.subject.meshFetal Developmenten
dc.subject.meshFetal Growth Retardationen
dc.subject.meshFood Contaminationen
dc.subject.meshHumansen
dc.subject.meshPolychlorinated Biphenylsen
dc.subject.meshPregnancyen
dc.subject.meshQuestionnairesen
dc.subject.meshSeafooden
dc.titleLinking exposure to polychlorinated biphenyls with fatty fish consumption and reduced fetal growth among Danish pregnant women: a cause for concern?en
dc.typeArticleen
dc.identifier.eissn1476-6256-
dc.contributor.departmentMaternal Nutrition Group, Department of Epidemiology Research, Statens Serum Institut, Arillerivej 5, Building 206, 2300 Copenhagen, Denmark. lur@ssi.dken
dc.identifier.journalAmerican journal of epidemiologyen

Related articles on PubMed

All Items in Hirsla are protected by copyright, with all rights reserved, unless otherwise indicated.