Influence of n-3 polyunsaturated fatty acids on soluble cellular adhesion molecules as biomarkers of cardiovascular risk in young healthy subjects

2.50
Hdl Handle:
http://hdl.handle.net/2336/42346
Title:
Influence of n-3 polyunsaturated fatty acids on soluble cellular adhesion molecules as biomarkers of cardiovascular risk in young healthy subjects
Authors:
Paulo, Maria C; Andrade, Ana M; Andrade, Maria L; Morais, Maria G; Kiely, Mairead; Parra, Dolores; Martinéz, J Alfredo; Thorsdottir, Inga; Bandarra, Narcisa M
Citation:
Nutr Metab Cardiovasc Dis. 2008, 18(10):664-70
Issue Date:
1-Dec-2008
Abstract:
BACKGROUND AND AIM: Serum levels of soluble cellular adhesion molecules (CAMs) and blood lipid parameters have been used as markers of inflammatory processes associated with cardiovascular disease (CVD) events. The present study evaluated the effects of the intake of n-3 polyunsaturated fatty acids (PUFAs) in fish and fish oil within energy-restricted diets, on soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular adhesion molecule-1 (sVCAM-1). METHODS AND RESULTS: Two hundred and seventy-five healthy European subjects aged between 20 and 40 years, were randomized to one of four hypocaloric dietary groups: control (sunflower oil capsules, no seafood), lean fish (3 x 150 g portions of cod/week), fatty fish (3 x 150 g portions of salmon/week), fish oil ((docosahexaenoic acid (DHA)+eicosapentaenoic acid (EPA) capsules, no seafood)). Diets rich in lean fish significantly decreased ICAM-1 levels, around 5% from baseline to endpoint (p<0.05), and had no effect on VCAM-1 levels. No significant differences were observed in sICAM-1 levels after the intervention with fatty fish or fish oils. On the other hand, these two seafood based diets were responsible for a significant increase of VCAM-1 levels [fatty fish; 16.1% and fish oil; 21.9%] respectively (p<0.05). CONCLUSIONS: CAMs as inflammatory biomarkers in young and healthy subjects are not conclusive for the evaluation of CVD risk. Hypocaloric fish diets had a different effect on CAMs, being lean fish responsible for the highest decrease in ICAM-1. On the other hand, VCAM-1 results allow speculation that a low dose of n-3 PUFA may be anti-inflammatory contrarily to a high dose which can have a pro-inflammatory effect. CAMs mechanism is complex and affected by multiple factors such as lifestyle, gender, and n-3 dose and source.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.sciencedirect.com/science/article/B7MFR-4S97JJY-1/2/165faa7971f4cfca45b1efe2bd80bd2f

Full metadata record

DC FieldValue Language
dc.contributor.authorPaulo, Maria C-
dc.contributor.authorAndrade, Ana M-
dc.contributor.authorAndrade, Maria L-
dc.contributor.authorMorais, Maria G-
dc.contributor.authorKiely, Mairead-
dc.contributor.authorParra, Dolores-
dc.contributor.authorMartinéz, J Alfredo-
dc.contributor.authorThorsdottir, Inga-
dc.contributor.authorBandarra, Narcisa M-
dc.date.accessioned2008-12-15T14:09:44Z-
dc.date.available2008-12-15T14:09:44Z-
dc.date.issued2008-12-01-
dc.date.submitted2008-12-15-
dc.identifier.citationNutr Metab Cardiovasc Dis. 2008, 18(10):664-70en
dc.identifier.issn0939-4753-
dc.identifier.pmid18420395-
dc.identifier.doi10.1016/j.numecd.2007.11.007-
dc.identifier.urihttp://hdl.handle.net/2336/42346-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND AND AIM: Serum levels of soluble cellular adhesion molecules (CAMs) and blood lipid parameters have been used as markers of inflammatory processes associated with cardiovascular disease (CVD) events. The present study evaluated the effects of the intake of n-3 polyunsaturated fatty acids (PUFAs) in fish and fish oil within energy-restricted diets, on soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular adhesion molecule-1 (sVCAM-1). METHODS AND RESULTS: Two hundred and seventy-five healthy European subjects aged between 20 and 40 years, were randomized to one of four hypocaloric dietary groups: control (sunflower oil capsules, no seafood), lean fish (3 x 150 g portions of cod/week), fatty fish (3 x 150 g portions of salmon/week), fish oil ((docosahexaenoic acid (DHA)+eicosapentaenoic acid (EPA) capsules, no seafood)). Diets rich in lean fish significantly decreased ICAM-1 levels, around 5% from baseline to endpoint (p<0.05), and had no effect on VCAM-1 levels. No significant differences were observed in sICAM-1 levels after the intervention with fatty fish or fish oils. On the other hand, these two seafood based diets were responsible for a significant increase of VCAM-1 levels [fatty fish; 16.1% and fish oil; 21.9%] respectively (p<0.05). CONCLUSIONS: CAMs as inflammatory biomarkers in young and healthy subjects are not conclusive for the evaluation of CVD risk. Hypocaloric fish diets had a different effect on CAMs, being lean fish responsible for the highest decrease in ICAM-1. On the other hand, VCAM-1 results allow speculation that a low dose of n-3 PUFA may be anti-inflammatory contrarily to a high dose which can have a pro-inflammatory effect. CAMs mechanism is complex and affected by multiple factors such as lifestyle, gender, and n-3 dose and source.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://www.sciencedirect.com/science/article/B7MFR-4S97JJY-1/2/165faa7971f4cfca45b1efe2bd80bd2fen
dc.subject.meshPubMed - in processen
dc.titleInfluence of n-3 polyunsaturated fatty acids on soluble cellular adhesion molecules as biomarkers of cardiovascular risk in young healthy subjectsen
dc.typeArticleen
dc.identifier.eissn1590-3729-
dc.contributor.departmentThe National Research Institute of Agriculture and Fisheries Research, Lisbon, Portugal.en
dc.identifier.journalNutrition, metabolism, and cardiovascular diseases : NMCDen
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