Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer

2.50
Hdl Handle:
http://hdl.handle.net/2336/42361
Title:
Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer
Authors:
Stacey, Simon N; Manolescu, Andrei; Sulem, Patrick; Thorlacius, Steinunn; Gudjonsson, Sigurjon A; Jonsson, Gudbjorn F; Jakobsdottir, Margret; Bergthorsson, Jon T; Gudmundsson, Julius; Aben, Katja K; Strobbe, Luc J; Swinkels, Dorine W; van Engelenburg, K C Anton; Henderson, Brian E; Kolonel, Laurence N; Le Marchand, Loic; Millastre, Esther; Andres, Raquel; Saez, Berta; Lambea, Julio; Godino, Javier; Polo, Eduardo; Tres, Alejandro; Picelli, Simone; Rantala, Johanna; Margolin, Sara; Jonsson, Thorvaldur; Sigurdsson, Helgi; Jonsdottir, Thora; Hrafnkelsson, Jon; Johannsson, Jakob; Sveinsson, Thorarinn; Myrdal, Gardar; Grimsson, Hlynur Niels; Sveinsdottir, Steinunn G; Alexiusdottir, Kristin; Saemundsdottir, Jona; Sigurdsson, Asgeir; Kostic, Jelena; Gudmundsson, Larus; Kristjansson, Kristleifur; Masson, Gisli; Fackenthal, James D; Adebamowo, Clement; Ogundiran, Temidayo; Olopade, Olufunmilayo I; Haiman, Christopher A; Lindblom, Annika; Mayordomo, Jose I; Kiemeney, Lambertus A; Gulcher, Jeffrey R; Rafnar, Thorunn; Thorsteinsdottir, Unnur; Johannsson, Oskar T; Kong, Augustine; Stefansson, Kari
Citation:
Nat. Genet. 2008, 40(6):703-6
Issue Date:
1-Jun-2008
Abstract:
We carried out a genome-wide association study of breast cancer predisposition with replication and refinement studies involving 6,145 cases and 33,016 controls and identified two SNPs (rs4415084 and rs10941679) on 5p12 that confer risk, preferentially for estrogen receptor (ER)-positive tumors (OR = 1.27, P = 2.5 x 10(-12) for rs10941679). The nearest gene, MRPS30, was previously implicated in apoptosis, ER-positive tumors and favorable prognosis. A recently reported signal in FGFR2 was also found to associate specifically with ER-positive breast cancer.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1038/ng.131

Full metadata record

DC FieldValue Language
dc.contributor.authorStacey, Simon N-
dc.contributor.authorManolescu, Andrei-
dc.contributor.authorSulem, Patrick-
dc.contributor.authorThorlacius, Steinunn-
dc.contributor.authorGudjonsson, Sigurjon A-
dc.contributor.authorJonsson, Gudbjorn F-
dc.contributor.authorJakobsdottir, Margret-
dc.contributor.authorBergthorsson, Jon T-
dc.contributor.authorGudmundsson, Julius-
dc.contributor.authorAben, Katja K-
dc.contributor.authorStrobbe, Luc J-
dc.contributor.authorSwinkels, Dorine W-
dc.contributor.authorvan Engelenburg, K C Anton-
dc.contributor.authorHenderson, Brian E-
dc.contributor.authorKolonel, Laurence N-
dc.contributor.authorLe Marchand, Loic-
dc.contributor.authorMillastre, Esther-
dc.contributor.authorAndres, Raquel-
dc.contributor.authorSaez, Berta-
dc.contributor.authorLambea, Julio-
dc.contributor.authorGodino, Javier-
dc.contributor.authorPolo, Eduardo-
dc.contributor.authorTres, Alejandro-
dc.contributor.authorPicelli, Simone-
dc.contributor.authorRantala, Johanna-
dc.contributor.authorMargolin, Sara-
dc.contributor.authorJonsson, Thorvaldur-
dc.contributor.authorSigurdsson, Helgi-
dc.contributor.authorJonsdottir, Thora-
dc.contributor.authorHrafnkelsson, Jon-
dc.contributor.authorJohannsson, Jakob-
dc.contributor.authorSveinsson, Thorarinn-
dc.contributor.authorMyrdal, Gardar-
dc.contributor.authorGrimsson, Hlynur Niels-
dc.contributor.authorSveinsdottir, Steinunn G-
dc.contributor.authorAlexiusdottir, Kristin-
dc.contributor.authorSaemundsdottir, Jona-
dc.contributor.authorSigurdsson, Asgeir-
dc.contributor.authorKostic, Jelena-
dc.contributor.authorGudmundsson, Larus-
dc.contributor.authorKristjansson, Kristleifur-
dc.contributor.authorMasson, Gisli-
dc.contributor.authorFackenthal, James D-
dc.contributor.authorAdebamowo, Clement-
dc.contributor.authorOgundiran, Temidayo-
dc.contributor.authorOlopade, Olufunmilayo I-
dc.contributor.authorHaiman, Christopher A-
dc.contributor.authorLindblom, Annika-
dc.contributor.authorMayordomo, Jose I-
dc.contributor.authorKiemeney, Lambertus A-
dc.contributor.authorGulcher, Jeffrey R-
dc.contributor.authorRafnar, Thorunn-
dc.contributor.authorThorsteinsdottir, Unnur-
dc.contributor.authorJohannsson, Oskar T-
dc.contributor.authorKong, Augustine-
dc.contributor.authorStefansson, Kari-
dc.date.accessioned2008-12-15T11:37:45Z-
dc.date.available2008-12-15T11:37:45Z-
dc.date.issued2008-06-01-
dc.date.submitted2008-12-15-
dc.identifier.citationNat. Genet. 2008, 40(6):703-6en
dc.identifier.issn1061-4036-
dc.identifier.pmid18438407-
dc.identifier.doi10.1038/ng.131-
dc.identifier.urihttp://hdl.handle.net/2336/42361-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractWe carried out a genome-wide association study of breast cancer predisposition with replication and refinement studies involving 6,145 cases and 33,016 controls and identified two SNPs (rs4415084 and rs10941679) on 5p12 that confer risk, preferentially for estrogen receptor (ER)-positive tumors (OR = 1.27, P = 2.5 x 10(-12) for rs10941679). The nearest gene, MRPS30, was previously implicated in apoptosis, ER-positive tumors and favorable prognosis. A recently reported signal in FGFR2 was also found to associate specifically with ER-positive breast cancer.en
dc.language.isoenen
dc.publisherNature Pub. Co.en
dc.relation.urlhttp://dx.doi.org/10.1038/ng.131en
dc.subject.meshAdenocarcinomaen
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshApoptosisen
dc.subject.meshBreast Neoplasmsen
dc.subject.meshCarcinoma, Ductal, Breasten
dc.subject.meshCarcinoma, Intraductal, Noninfiltratingen
dc.subject.meshCarcinoma, Lobularen
dc.subject.meshCarcinoma, Medullaryen
dc.subject.meshCase-Control Studiesen
dc.subject.meshChromosomes, Human, Pair 5en
dc.subject.meshCohort Studiesen
dc.subject.meshFemaleen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshHumansen
dc.subject.meshInternational Agenciesen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshPolymorphism, Single Nucleotideen
dc.subject.meshPrognosisen
dc.subject.meshReceptor, Fibroblast Growth Factor, Type 2en
dc.subject.meshReceptors, Estrogenen
dc.subject.meshRibosomal Proteinsen
dc.subject.meshVariation (Genetics)en
dc.titleCommon variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast canceren
dc.typeArticleen
dc.identifier.eissn1546-1718-
dc.contributor.departmentdeCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland. simon.stacey@decode.isen
dc.identifier.journalNature geneticsen

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