Short-term outcome of neuropsychiatric events in systemic lupus erythematosus upon enrollment into an international inception cohort study

2.50
Hdl Handle:
http://hdl.handle.net/2336/42362
Title:
Short-term outcome of neuropsychiatric events in systemic lupus erythematosus upon enrollment into an international inception cohort study
Authors:
Hanly, J G; Urowitz, M B; Su, L; Sanchez-Guerrero, J; Bae, S C; Gordon, C; Wallace, D J; Isenberg, D; Alarcón, G S; Merrill, J T; Clarke, A; Bernatsky, S; Dooley, M A; Fortin, P R; Gladman, D; Steinsson, K; Petri, M; Bruce, I N; Manzi, S; Khamashta, M; Zoma, A; Font, J; Van Vollenhoven, R; Aranow, C; Ginzler, E; Nived, O; Sturfelt, G; Ramsey-Goldman, R; Kalunian, K; Douglas, J; Qiufen Qi, K; Thompson, K; Farewell, V
Citation:
Arthritis Rheum. 2008, 59(5):721-9
Issue Date:
15-May-2008
Abstract:
OBJECTIVE: To determine the short-term outcome of neuropsychiatric (NP) events upon enrollment into an international inception cohort of patients with systemic lupus erythematosus (SLE). METHODS: The study was performed by the Systemic Lupus International Collaborating Clinics. Patients were enrolled within 15 months of SLE diagnosis and NP events were characterized using the American College of Rheumatology case definitions. Decision rules were derived to identify NP events attributable to SLE. Physician outcome scores of NP events and patient-derived mental component summary (MCS) and physical component summary (PCS) scores of the Short Form 36 were recorded. RESULTS: There were 890 patients (88.7% female) with a mean +/- SD age of 33.8 +/- 13.4 years and mean disease duration of 5.3 +/- 4.2 months. Within the enrollment window, 271 (33.5%) of 890 patients had at least 1 NP event encompassing 15 NP syndromes. NP events attributed to SLE varied from 16.5% to 33.9% using alternate attribution models and occurred in 6.0-11.5% of patients. Outcome scores for NP events attributed to SLE were significantly better than for NP events due to non-SLE causes. Higher global disease activity was associated with worse outcomes. MCS scores were lower in patients with NP events, regardless of attribution, and were also lower in patients with diffuse and central NP events. There was a significant association between physician outcome scores and patient MCS scores only for NP events attributed to SLE. CONCLUSION: In SLE patients, the short-term outcome of NP events is determined by both the characteristics and attribution of the events.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1002/art.23566

Full metadata record

DC FieldValue Language
dc.contributor.authorHanly, J G-
dc.contributor.authorUrowitz, M B-
dc.contributor.authorSu, L-
dc.contributor.authorSanchez-Guerrero, J-
dc.contributor.authorBae, S C-
dc.contributor.authorGordon, C-
dc.contributor.authorWallace, D J-
dc.contributor.authorIsenberg, D-
dc.contributor.authorAlarcón, G S-
dc.contributor.authorMerrill, J T-
dc.contributor.authorClarke, A-
dc.contributor.authorBernatsky, S-
dc.contributor.authorDooley, M A-
dc.contributor.authorFortin, P R-
dc.contributor.authorGladman, D-
dc.contributor.authorSteinsson, K-
dc.contributor.authorPetri, M-
dc.contributor.authorBruce, I N-
dc.contributor.authorManzi, S-
dc.contributor.authorKhamashta, M-
dc.contributor.authorZoma, A-
dc.contributor.authorFont, J-
dc.contributor.authorVan Vollenhoven, R-
dc.contributor.authorAranow, C-
dc.contributor.authorGinzler, E-
dc.contributor.authorNived, O-
dc.contributor.authorSturfelt, G-
dc.contributor.authorRamsey-Goldman, R-
dc.contributor.authorKalunian, K-
dc.contributor.authorDouglas, J-
dc.contributor.authorQiufen Qi, K-
dc.contributor.authorThompson, K-
dc.contributor.authorFarewell, V-
dc.date.accessioned2008-12-15T13:21:58Z-
dc.date.available2008-12-15T13:21:58Z-
dc.date.issued2008-05-15-
dc.date.submitted2008-12-15-
dc.identifier.citationArthritis Rheum. 2008, 59(5):721-9en
dc.identifier.issn0004-3591-
dc.identifier.pmid18438902-
dc.identifier.doi10.1002/art.23566-
dc.identifier.urihttp://hdl.handle.net/2336/42362-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVE: To determine the short-term outcome of neuropsychiatric (NP) events upon enrollment into an international inception cohort of patients with systemic lupus erythematosus (SLE). METHODS: The study was performed by the Systemic Lupus International Collaborating Clinics. Patients were enrolled within 15 months of SLE diagnosis and NP events were characterized using the American College of Rheumatology case definitions. Decision rules were derived to identify NP events attributable to SLE. Physician outcome scores of NP events and patient-derived mental component summary (MCS) and physical component summary (PCS) scores of the Short Form 36 were recorded. RESULTS: There were 890 patients (88.7% female) with a mean +/- SD age of 33.8 +/- 13.4 years and mean disease duration of 5.3 +/- 4.2 months. Within the enrollment window, 271 (33.5%) of 890 patients had at least 1 NP event encompassing 15 NP syndromes. NP events attributed to SLE varied from 16.5% to 33.9% using alternate attribution models and occurred in 6.0-11.5% of patients. Outcome scores for NP events attributed to SLE were significantly better than for NP events due to non-SLE causes. Higher global disease activity was associated with worse outcomes. MCS scores were lower in patients with NP events, regardless of attribution, and were also lower in patients with diffuse and central NP events. There was a significant association between physician outcome scores and patient MCS scores only for NP events attributed to SLE. CONCLUSION: In SLE patients, the short-term outcome of NP events is determined by both the characteristics and attribution of the events.en
dc.language.isoenen
dc.publisherWiley-Liss, Inc.en
dc.relation.urlhttp://dx.doi.org/10.1002/art.23566en
dc.subject.meshAdulten
dc.subject.meshCentral Nervous System Diseasesen
dc.subject.meshCohort Studiesen
dc.subject.meshComorbidityen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshInternational Cooperationen
dc.subject.meshLupus Erythematosus, Systemicen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshNeuropsychological Testsen
dc.titleShort-term outcome of neuropsychiatric events in systemic lupus erythematosus upon enrollment into an international inception cohort studyen
dc.typeArticleen
dc.identifier.eissn1529-0131-
dc.contributor.departmentQueen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada. john.hanly@cdha.nshealth.caen
dc.identifier.journalArthritis and rheumatismen

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