Survival and trends of occurrence of left ventricular hypertrophy, gender differences, 1967-92: The Reykjavik Study.

2.50
Hdl Handle:
http://hdl.handle.net/2336/4494
Title:
Survival and trends of occurrence of left ventricular hypertrophy, gender differences, 1967-92: The Reykjavik Study.
Authors:
Thrainsdottir, I S; Hardarson, Th; Thorgeirsson, G; Sigvaldason, H; Sigfusson, N
Citation:
J. Intern. Med. 2003, 253(4):418-24
Issue Date:
1-Apr-2003
Abstract:
OBJECTIVE: We estimated the prevalence, incidence and risk factors of left ventricular hypertrophy (LVH) in a prospective cohort study of 26 489 participants. MATERIAL AND METHODS: The LVH was defined as Minnesota Code 310 on electrocardiogram (ECG). Everyone with this code at first visit was defined as a prevalence case and those who developed it between subsequent visits were incidence cases. The comparison cohort were all other participants in the Reykjavik Study stages I-V. RESULTS: A total of 297 men and 49 women were found to have LVH of 3.2% and 0.5%, respectively. The incidence was 25 per 1000 per year amongst men and six per 1000 per year amongst women. Prevalence in both genders increased with increasing age. Risk factors at the time of diagnosis were systolic blood pressure [odds ratio (OR) per mmHg 1.02; 95% confidence interval (CI): 1.01-1.03], age (OR per year 1.04; 95% CI: 1.02-1.05), silent myocardial infarction (MI) (OR 3.18; 95% CI: 1.39-7.27) and ST-T changes (OR 3.06; 95% CI: 2.14-4.38) amongst men and systolic blood pressure and age for women with similar odds ratio. Predictive factors for acquiring LVH were systolic blood pressure [incidence ratio (IR) 1.01; 95% CI: 1.01-1.02] and angina with ECG changes (IR 2.33; 95% CI: 1.08-5.02) amongst men and systolic blood pressure amongst women (IR 1.03; 95% CI: 1.01-1.04). The risk for coronary mortality was significantly increased amongst women with hypertrophy [hazard ratio (HR) 3.07; 95% CI: 1.5-6.31] and their total survival was poorer with increasing time from diagnosis of LVH (HR 2.17; 95% CI: 1.36-3.48). CONCLUSIONS: We conclude that the presence of LVH and its appearance is associated with age and increased blood pressure amongst both genders. Women with LVH have poorer survival than other women and they are at threefold risk of dying of ischaemic heart disease.
Additional Links:
http://www.blackwell-synergy.com/doi/abs/10.1046/j.1365-2796.2003.01111.x; http://www.blackwell-synergy.com/doi/full/10.1046/j.1365-2796.2003.01111.x?cookieSet=1

Full metadata record

DC FieldValue Language
dc.contributor.authorThrainsdottir, I S-
dc.contributor.authorHardarson, Th-
dc.contributor.authorThorgeirsson, G-
dc.contributor.authorSigvaldason, H-
dc.contributor.authorSigfusson, N-
dc.date.accessioned2006-09-20T08:22:40Z-
dc.date.available2006-09-20T08:22:40Z-
dc.date.issued2003-04-01-
dc.identifier.citationJ. Intern. Med. 2003, 253(4):418-24en
dc.identifier.issn0954-6820-
dc.identifier.pmid12653870-
dc.identifier.doidoi:10.1046/j.1365-2796.2003.01111.x-
dc.identifier.otherCAR12-
dc.identifier.urihttp://hdl.handle.net/2336/4494-
dc.description.abstractOBJECTIVE: We estimated the prevalence, incidence and risk factors of left ventricular hypertrophy (LVH) in a prospective cohort study of 26 489 participants. MATERIAL AND METHODS: The LVH was defined as Minnesota Code 310 on electrocardiogram (ECG). Everyone with this code at first visit was defined as a prevalence case and those who developed it between subsequent visits were incidence cases. The comparison cohort were all other participants in the Reykjavik Study stages I-V. RESULTS: A total of 297 men and 49 women were found to have LVH of 3.2% and 0.5%, respectively. The incidence was 25 per 1000 per year amongst men and six per 1000 per year amongst women. Prevalence in both genders increased with increasing age. Risk factors at the time of diagnosis were systolic blood pressure [odds ratio (OR) per mmHg 1.02; 95% confidence interval (CI): 1.01-1.03], age (OR per year 1.04; 95% CI: 1.02-1.05), silent myocardial infarction (MI) (OR 3.18; 95% CI: 1.39-7.27) and ST-T changes (OR 3.06; 95% CI: 2.14-4.38) amongst men and systolic blood pressure and age for women with similar odds ratio. Predictive factors for acquiring LVH were systolic blood pressure [incidence ratio (IR) 1.01; 95% CI: 1.01-1.02] and angina with ECG changes (IR 2.33; 95% CI: 1.08-5.02) amongst men and systolic blood pressure amongst women (IR 1.03; 95% CI: 1.01-1.04). The risk for coronary mortality was significantly increased amongst women with hypertrophy [hazard ratio (HR) 3.07; 95% CI: 1.5-6.31] and their total survival was poorer with increasing time from diagnosis of LVH (HR 2.17; 95% CI: 1.36-3.48). CONCLUSIONS: We conclude that the presence of LVH and its appearance is associated with age and increased blood pressure amongst both genders. Women with LVH have poorer survival than other women and they are at threefold risk of dying of ischaemic heart disease.en
dc.language.isoenen
dc.publisherBlackwell Publishingen
dc.relation.urlhttp://www.blackwell-synergy.com/doi/abs/10.1046/j.1365-2796.2003.01111.xen
dc.relation.urlhttp://www.blackwell-synergy.com/doi/full/10.1046/j.1365-2796.2003.01111.x?cookieSet=1en
dc.subject.meshAge Factorsen
dc.subject.meshAgeden
dc.subject.meshCohort Studiesen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshHypertrophy, Left Ventricular/epidemiology/*mortalityen
dc.subject.meshIceland/epidemiologyen
dc.subject.meshIncidenceen
dc.subject.meshMaleen
dc.subject.meshProspective Studiesen
dc.subject.meshRisk Factorsen
dc.subject.meshSex Distributionen
dc.subject.meshSurvival Analysisen
dc.titleSurvival and trends of occurrence of left ventricular hypertrophy, gender differences, 1967-92: The Reykjavik Study.en
dc.typeArticleen
dc.format.digYES-

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