The effect of reducing levels of cat allergen (Fel d 1) on clinical symptoms in patients with cat allergy

2.50
Hdl Handle:
http://hdl.handle.net/2336/4535
Title:
The effect of reducing levels of cat allergen (Fel d 1) on clinical symptoms in patients with cat allergy
Authors:
Bjornsdottir, Unnur Steina; Jakobinudottir, Sigridur; Runarsdottir, Valgerdur; Juliusson, Sigurdur
Citation:
Ann. Allergy Asthma Immunol. 2003, 91(2):189-94
Issue Date:
1-Aug-2003
Abstract:
BACKGROUND: Treatment of cat allergy normally entails removal of the cat from the household, but cat owners are often unwilling to part with their pets, despite clinically relevant allergies. OBJECTIVE: To determine whether levels of Fel d 1 can be reduced without removal of the cat and whether this will affect symptoms of cat allergy. METHODS: Cat-allergic patients underwent randomization to either a group instructed in environmental control (EC) and a group with unchanged environment (UE). Dust samples were obtained and settled Fel d 1 measured by enzyme-linked immunosorbent assay. Patients recorded daily nasal inspiratory flow rates. At baseline, 3 months, and 8 months, patients underwent symptom evaluation. RESULTS: Eighteen patients were randomized to the EC group and 22 to the UE group; the final number completing the study was 31, 15 in the EC group, and 16 in the UE group. At 8 months, home Fel d 1 levels had diminished to 6.8% of baseline levels in the EC group, whereas no reduction in levels was noted in the UE group. In the EC group, significant improvements were found in nasal inspiratory flow rate and symptoms compared with the UE group. Patients did not have difficulties adhering to EC measures. CONCLUSION: A decrease in the allergen load was found in the EC group, which had a significant effect on symptoms of nasal allergy.
Additional Links:
http://www.ingentaconnect.com/content/acaai/aaai/2003/00000091/00000002/art00018

Full metadata record

DC FieldValue Language
dc.contributor.authorBjornsdottir, Unnur Steina-
dc.contributor.authorJakobinudottir, Sigridur-
dc.contributor.authorRunarsdottir, Valgerdur-
dc.contributor.authorJuliusson, Sigurdur-
dc.date.accessioned2006-09-21T09:23:16Z-
dc.date.available2006-09-21T09:23:16Z-
dc.date.issued2003-08-01-
dc.identifier.citationAnn. Allergy Asthma Immunol. 2003, 91(2):189-94en
dc.identifier.issn1081-1206-
dc.identifier.pmid12952114-
dc.identifier.otherPAD12-
dc.identifier.urihttp://hdl.handle.net/2336/4535-
dc.description.abstractBACKGROUND: Treatment of cat allergy normally entails removal of the cat from the household, but cat owners are often unwilling to part with their pets, despite clinically relevant allergies. OBJECTIVE: To determine whether levels of Fel d 1 can be reduced without removal of the cat and whether this will affect symptoms of cat allergy. METHODS: Cat-allergic patients underwent randomization to either a group instructed in environmental control (EC) and a group with unchanged environment (UE). Dust samples were obtained and settled Fel d 1 measured by enzyme-linked immunosorbent assay. Patients recorded daily nasal inspiratory flow rates. At baseline, 3 months, and 8 months, patients underwent symptom evaluation. RESULTS: Eighteen patients were randomized to the EC group and 22 to the UE group; the final number completing the study was 31, 15 in the EC group, and 16 in the UE group. At 8 months, home Fel d 1 levels had diminished to 6.8% of baseline levels in the EC group, whereas no reduction in levels was noted in the UE group. In the EC group, significant improvements were found in nasal inspiratory flow rate and symptoms compared with the UE group. Patients did not have difficulties adhering to EC measures. CONCLUSION: A decrease in the allergen load was found in the EC group, which had a significant effect on symptoms of nasal allergy.en
dc.language.isoenen
dc.publisherAmerican College of Allergy, Asthma, and Immunologyen
dc.relation.urlhttp://www.ingentaconnect.com/content/acaai/aaai/2003/00000091/00000002/art00018en
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAnimalsen
dc.subject.meshAnimals, Domesticen
dc.subject.meshCatsen
dc.subject.meshDusten
dc.subject.meshEnvironment, Controlleden
dc.subject.meshEnvironmental Exposureen
dc.subject.meshFemaleen
dc.subject.meshGlycoproteinsen
dc.subject.meshHousekeepingen
dc.subject.meshHumansen
dc.subject.meshHypersensitivityen
dc.subject.meshRandomized Controlled Trialsen
dc.subject.meshResearch Support, Non-U.S. Gov'ten
dc.subject.meshRhinitisen
dc.subject.meshVentilationen
dc.titleThe effect of reducing levels of cat allergen (Fel d 1) on clinical symptoms in patients with cat allergyen
dc.typeArticleen
dc.format.digYES-

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