2.50
Hdl Handle:
http://hdl.handle.net/2336/4579
Title:
The effects of antiglaucoma and systemic medications on ocular blood flow
Authors:
Costa, Vital P; Harris, Alon; Stefansson, Einar; Flammer, Josef; Krieglstein, Gunter K; Orzalesi, Nicola; Heijl, Anders; Renard, Jean-Paul; Serra, Luis Metzner
Citation:
Prog Retin Eye Res 2003, 22(6):769-805
Issue Date:
1-Nov-2003
Abstract:
Based on the body of evidence implicating ocular blood flow disturbances in the pathogenesis of glaucoma, there is great interest in the investigation of the effects of antiglaucoma drugs and systemic medications on the various ocular vascular beds. The primary aim of this article was to review the current data available on the effects of antiglaucoma drugs and systemic medications on ocular blood flow. We performed a literature search in November 2002, which consisted of a textword search in MEDLINE for the years 1968-2002. The results of this review suggest that there is a severe lack of well-designed long-term studies investigating the effects of antiglaucoma and systemic medications on ocular blood flow in glaucomatous patients. However, among the 136 articles dealing with the effect of antiglaucoma drugs on ocular blood flow, only 36 (26.5%) investigated the effects of medications on glaucoma patients. Among these 36 articles, only 3 (8.3%) were long-term studies, and only 16 (44.4%) were double-masked, randomized, prospective trials. Among the 33 articles describing the effects of systemic medications on ocular blood flow, only 11 (33.3%) investigated glaucoma patients, of which only one (9.1%) was a double-masked, randomized, prospective trial. Based on this preliminary data, we would intimate that few antiglaucoma medications have the potential to directly improve ocular blood flow. Unoprostone appears to have a reproducible antiendothelin-1 effect, betaxolol may exert a calcium-channel blocker action, apraclonidine consistently leads to anterior segment vasoconstriction, and carbonic anhydrase inhibitors seem to accelerate the retinal circulation. Longitudinal, prospective, randomized trials are needed to investigate the effects of vasoactive substances with no hypotensive effect on the progression of glaucoma.
Additional Links:
http://www.sciencedirect.com/science/article/B6TBT-49H1JJ1-1/2/a82041407481c34765bfbf5caca8e5d8

Full metadata record

DC FieldValue Language
dc.contributor.authorCosta, Vital P-
dc.contributor.authorHarris, Alon-
dc.contributor.authorStefansson, Einar-
dc.contributor.authorFlammer, Josef-
dc.contributor.authorKrieglstein, Gunter K-
dc.contributor.authorOrzalesi, Nicola-
dc.contributor.authorHeijl, Anders-
dc.contributor.authorRenard, Jean-Paul-
dc.contributor.authorSerra, Luis Metzner-
dc.date.accessioned2006-09-22T15:51:28Z-
dc.date.available2006-09-22T15:51:28Z-
dc.date.issued2003-11-01-
dc.identifier.citationProg Retin Eye Res 2003, 22(6):769-805en
dc.identifier.issn1350-9462-
dc.identifier.pmid14575724-
dc.identifier.doidoi:10.1016/S1350-9462(03)00064-8-
dc.identifier.otherOPH12-
dc.identifier.urihttp://hdl.handle.net/2336/4579-
dc.description.abstractBased on the body of evidence implicating ocular blood flow disturbances in the pathogenesis of glaucoma, there is great interest in the investigation of the effects of antiglaucoma drugs and systemic medications on the various ocular vascular beds. The primary aim of this article was to review the current data available on the effects of antiglaucoma drugs and systemic medications on ocular blood flow. We performed a literature search in November 2002, which consisted of a textword search in MEDLINE for the years 1968-2002. The results of this review suggest that there is a severe lack of well-designed long-term studies investigating the effects of antiglaucoma and systemic medications on ocular blood flow in glaucomatous patients. However, among the 136 articles dealing with the effect of antiglaucoma drugs on ocular blood flow, only 36 (26.5%) investigated the effects of medications on glaucoma patients. Among these 36 articles, only 3 (8.3%) were long-term studies, and only 16 (44.4%) were double-masked, randomized, prospective trials. Among the 33 articles describing the effects of systemic medications on ocular blood flow, only 11 (33.3%) investigated glaucoma patients, of which only one (9.1%) was a double-masked, randomized, prospective trial. Based on this preliminary data, we would intimate that few antiglaucoma medications have the potential to directly improve ocular blood flow. Unoprostone appears to have a reproducible antiendothelin-1 effect, betaxolol may exert a calcium-channel blocker action, apraclonidine consistently leads to anterior segment vasoconstriction, and carbonic anhydrase inhibitors seem to accelerate the retinal circulation. Longitudinal, prospective, randomized trials are needed to investigate the effects of vasoactive substances with no hypotensive effect on the progression of glaucoma.en
dc.language.isoenen
dc.publisherPergamonen
dc.relation.urlhttp://www.sciencedirect.com/science/article/B6TBT-49H1JJ1-1/2/a82041407481c34765bfbf5caca8e5d8en
dc.subject.meshEyeen
dc.subject.meshGlaucomaen
dc.subject.meshHumansen
dc.subject.meshPharmacokineticsen
dc.subject.meshPharmacologyen
dc.subject.meshRegional Blood Flowen
dc.titleThe effects of antiglaucoma and systemic medications on ocular blood flowen
dc.typeArticleen
dc.identifier.journalProgress in retinal and eye researchen
dc.format.digYES-

Related articles on PubMed

All Items in Hirsla are protected by copyright, with all rights reserved, unless otherwise indicated.