Short-term gluten challenge in children with coeliac disease does not impair spontaneous growth hormone secretion

2.50
Hdl Handle:
http://hdl.handle.net/2336/4644
Title:
Short-term gluten challenge in children with coeliac disease does not impair spontaneous growth hormone secretion
Authors:
Jansson, Ulf H G; Kristiansson, Bengt; Albertsson-Wikland, Kerstin; Bjarnason, Ragnar
Citation:
J Pediatr Endocrinol Metab 2003, 16(5):771-8
Issue Date:
1-Jun-2003
Abstract:
BACKGROUND: Growth retardation in children with coeliac disease has been attributed to impaired growth hormone (GH) secretion observed in stimulation tests. OBJECTIVE: This study aimed at investigating the possible change in spontaneous GH secretion during a standardised gluten challenge. PATIENTS: Twelve children with previous enteropathy suggesting coeliac disease and a normal pre-challenge biopsy on a gluten-free diet were included; eight of them completed all parts of the study, including repeated 24-h GH sampling. METHODS: At the start and the end of a 5-6 weeks standardised gluten challenge, blood was drawn at a constant rate for 24 h and collected for GH analysis at 20-min intervals. The graph of plotted GH values was analysed by means of a computer program (PULSAR). RESULTS: No significant changes were seen in the measures of maximum GH peak, baseline GH values, area under the curve over the baseline (AUCb), the number of GH peaks or mean GH concentration. GH secretion rate (GHt) increased slightly. None of the characteristics of the 24-h profile was significantly correlated to the change of IGF-I. CONCLUSION: No impaired GH secretion was found. Thus, we speculate that decreased growth rate in celiac disease may not be primarily caused by changes in GH secretion. Instead it may be caused by changed peripheral sensitivity to GH.

Full metadata record

DC FieldValue Language
dc.contributor.authorJansson, Ulf H G-
dc.contributor.authorKristiansson, Bengt-
dc.contributor.authorAlbertsson-Wikland, Kerstin-
dc.contributor.authorBjarnason, Ragnar-
dc.date.accessioned2006-09-27T15:43:27Z-
dc.date.available2006-09-27T15:43:27Z-
dc.date.issued2003-06-01-
dc.identifier.citationJ Pediatr Endocrinol Metab 2003, 16(5):771-8en
dc.identifier.issn0334-018X-
dc.identifier.pmid12880127-
dc.identifier.otherPED12-
dc.identifier.urihttp://hdl.handle.net/2336/4644-
dc.description.abstractBACKGROUND: Growth retardation in children with coeliac disease has been attributed to impaired growth hormone (GH) secretion observed in stimulation tests. OBJECTIVE: This study aimed at investigating the possible change in spontaneous GH secretion during a standardised gluten challenge. PATIENTS: Twelve children with previous enteropathy suggesting coeliac disease and a normal pre-challenge biopsy on a gluten-free diet were included; eight of them completed all parts of the study, including repeated 24-h GH sampling. METHODS: At the start and the end of a 5-6 weeks standardised gluten challenge, blood was drawn at a constant rate for 24 h and collected for GH analysis at 20-min intervals. The graph of plotted GH values was analysed by means of a computer program (PULSAR). RESULTS: No significant changes were seen in the measures of maximum GH peak, baseline GH values, area under the curve over the baseline (AUCb), the number of GH peaks or mean GH concentration. GH secretion rate (GHt) increased slightly. None of the characteristics of the 24-h profile was significantly correlated to the change of IGF-I. CONCLUSION: No impaired GH secretion was found. Thus, we speculate that decreased growth rate in celiac disease may not be primarily caused by changes in GH secretion. Instead it may be caused by changed peripheral sensitivity to GH.en
dc.language.isoenen
dc.publisherFreund Pub. Houseen
dc.subject.meshCeliac Diseaseen
dc.subject.meshChilden
dc.subject.meshChild, Preschoolen
dc.subject.meshDieten
dc.subject.meshFemaleen
dc.subject.meshGlutenen
dc.subject.meshHuman Growth Hormoneen
dc.subject.meshInsulin-Like Growth Factor Binding Protein 3en
dc.subject.meshInsulin-Like Growth Factor Ien
dc.subject.meshIntestine, Smallen
dc.subject.meshSeverity of Illness Indexen
dc.subject.meshResearch Support, Non-U.S. Gov'ten
dc.titleShort-term gluten challenge in children with coeliac disease does not impair spontaneous growth hormone secretionen
dc.typeArticleen
dc.identifier.journalJournal of pediatric endocrinology & metabolism : JPEMen
dc.format.digYES-

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