Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2

2.50
Hdl Handle:
http://hdl.handle.net/2336/4647
Title:
Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2
Authors:
Reynisdottir, Inga; Thorleifsson, Gudmar; Benediktsson, Rafn; Sigurdsson, Gunnar; Emilsson, Valur; Einarsdottir, Anna Sigurlin; Hjorleifsdottir, Eyrun Edda; Orlygsdottir, Gudbjorg Th; Bjornsdottir, Gudrun Thora; Saemundsdottir, Jona; Halldorsson, Skarphedinn; Hrafnkelsdottir, Soffia; Sigurjonsdottir, Steinunn Bjorg; Steinsdottir, Svana; Martin, Mitchell; Kochan, Jarema P; Rhees, Brian K; Grant, Struan F A; Frigge, Michael L; Kong, Augustine; Gudnason, Vilmundur; Stefansson, Kari; Gulcher, Jeffrey R
Citation:
Am. J. Hum. Genet. 2003, 73(2):323-35
Issue Date:
1-Aug-2003
Abstract:
We report a genomewide linkage study of type 2 diabetes (T2D [MIM 125853]) in the Icelandic population. A list of type 2 diabetics was cross-matched with a computerized genealogical database clustering 763 type 2 diabetics into 227 families. The diabetic patients and their relatives were genotyped with 906 microsatellite markers. A nonparametric multipoint linkage analysis yielded linkage to 5q34-q35.2 (LOD = 2.90, P=1.29 x 10(-4)) in all diabetics. Since obesity, here defined as body mass index (BMI) > or =30 kg/m(2), is a key risk factor for the development of T2D, we studied the data either independently of BMI or by stratifying the patient group as obese (BMI > or =30) or nonobese (BMI <30). A nonparametric multipoint linkage analysis yielded linkage to 5q34-q35.2 (LOD = 3.64, P=2.12 x (10)-5) in the nonobese diabetics. No linkage was observed in this region for the obese diabetics. Linkage analysis conditioning on maternal transmission to the nonobese diabetics resulted in a LOD score of 3.48 (P=3.12 x 10(-5)) in the same region, whereas conditioning on paternal transmission led to a substantial drop in the LOD score. Finally, we observed potential interactions between the 5q locus and two T2D susceptibility loci, previously mapped in other populations.
Description:
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Additional Links:
http://www.journals.uchicago.edu/AJHG/journal/issues/v73n2/35005/35005.html

Full metadata record

DC FieldValue Language
dc.contributor.authorReynisdottir, Inga-
dc.contributor.authorThorleifsson, Gudmar-
dc.contributor.authorBenediktsson, Rafn-
dc.contributor.authorSigurdsson, Gunnar-
dc.contributor.authorEmilsson, Valur-
dc.contributor.authorEinarsdottir, Anna Sigurlin-
dc.contributor.authorHjorleifsdottir, Eyrun Edda-
dc.contributor.authorOrlygsdottir, Gudbjorg Th-
dc.contributor.authorBjornsdottir, Gudrun Thora-
dc.contributor.authorSaemundsdottir, Jona-
dc.contributor.authorHalldorsson, Skarphedinn-
dc.contributor.authorHrafnkelsdottir, Soffia-
dc.contributor.authorSigurjonsdottir, Steinunn Bjorg-
dc.contributor.authorSteinsdottir, Svana-
dc.contributor.authorMartin, Mitchell-
dc.contributor.authorKochan, Jarema P-
dc.contributor.authorRhees, Brian K-
dc.contributor.authorGrant, Struan F A-
dc.contributor.authorFrigge, Michael L-
dc.contributor.authorKong, Augustine-
dc.contributor.authorGudnason, Vilmundur-
dc.contributor.authorStefansson, Kari-
dc.contributor.authorGulcher, Jeffrey R-
dc.date.accessioned2006-09-28T09:53:01Z-
dc.date.available2006-09-28T09:53:01Z-
dc.date.issued2003-08-01-
dc.identifier.citationAm. J. Hum. Genet. 2003, 73(2):323-35en
dc.identifier.issn0002-9297-
dc.identifier.pmid12851856-
dc.identifier.otherEND12-
dc.identifier.urihttp://hdl.handle.net/2336/4647-
dc.descriptionTo access full text version of this article. Please click on the hyperlink "View/Open" at the bottom of this pageen
dc.descriptionTo access publisher version of this article. Please click on the hyperlink in Additional Link fielden
dc.description.abstractWe report a genomewide linkage study of type 2 diabetes (T2D [MIM 125853]) in the Icelandic population. A list of type 2 diabetics was cross-matched with a computerized genealogical database clustering 763 type 2 diabetics into 227 families. The diabetic patients and their relatives were genotyped with 906 microsatellite markers. A nonparametric multipoint linkage analysis yielded linkage to 5q34-q35.2 (LOD = 2.90, P=1.29 x 10(-4)) in all diabetics. Since obesity, here defined as body mass index (BMI) > or =30 kg/m(2), is a key risk factor for the development of T2D, we studied the data either independently of BMI or by stratifying the patient group as obese (BMI > or =30) or nonobese (BMI <30). A nonparametric multipoint linkage analysis yielded linkage to 5q34-q35.2 (LOD = 3.64, P=2.12 x (10)-5) in the nonobese diabetics. No linkage was observed in this region for the obese diabetics. Linkage analysis conditioning on maternal transmission to the nonobese diabetics resulted in a LOD score of 3.48 (P=3.12 x 10(-5)) in the same region, whereas conditioning on paternal transmission led to a substantial drop in the LOD score. Finally, we observed potential interactions between the 5q locus and two T2D susceptibility loci, previously mapped in other populations.en
dc.language.isoenen
dc.publisherUniversity of Chicago Pressen
dc.relation.urlhttp://www.journals.uchicago.edu/AJHG/journal/issues/v73n2/35005/35005.htmlen
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshBody Mass Indexen
dc.subject.meshChromosome Mappingen
dc.subject.meshChromosomes, Human, Pair 10en
dc.subject.meshChromosomes, Human, Pair 12en
dc.subject.meshChromosomes, Human, Pair 5en
dc.subject.meshDiabetes Mellitus, Type 2en
dc.subject.meshGenomic Imprintingen
dc.subject.meshLod Scoreen
dc.subject.meshMicrosatellite Repeatsen
dc.subject.meshObesityen
dc.subject.meshPedigreeen
dc.subject.meshPhenotypeen
dc.titleLocalization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2en
dc.typeArticleen
dc.identifier.journalAmerican journal of human geneticsen
dc.format.digYES-

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