Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1q

2.50
Hdl Handle:
http://hdl.handle.net/2336/4671
Title:
Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1q
Authors:
Curtis, David; Kalsi, Gursharan; Brynjolfsson, Jon; McInnis, Melvin; O'Neill, Jane; Smyth, Ciaran; Moloney, Eamonn; Murphy, Patrice; McQuillin, Andrew; Petursson, Hannes; Gurling, Hugh
Citation:
Psychiatr. Genet. 2003, 13(2):77-84
Issue Date:
1-Jun-2003
Abstract:
OBJECTIVE: To localize genes conferring susceptibility to bipolar affective disorder. METHODS: Seven families were selected on the basis of containing multiple cases of bipolar affective disorder present in three or more generations, an absence of schizophrenia and unilineal transmission. DNA samples from these families were genotyped with 365 microsatellite markers spaced at approximately 10 cM intervals across the whole genome. All markers were subjected to initial two-point and three-point analyses using LOD score and model-free analysis. All regions producing a result significant at P<0.01 were then subjected to four-point LOD score analysis under the assumption of heterogeneity. RESULTSA four-point LOD score of 2.8 was obtained using a dominant model and including unipolar cases as affected in the region of D12S342. Four-point LOD scores of 2 were obtained around D1S243, D1S251 and D3S1265. The positive results around D1S243 were accounted for by a LOD score of 3.1 occurring in a single pedigree. CONCLUSIONS: Since there has been previous strong support for linkage to the region of 12q23-q24 around D12S342, it now seems very probable that it does indeed contain a gene influencing susceptibility to bipolar affective disorder. Some evidence for linkage in the region of 1q near to D1S251 has been reported in one previous study. It therefore seems that this region of 1q and the region of 1p close to D1S243 may also harbour susceptibility genes.
Additional Links:
http://gateway.ovid.com/ovidweb.cgi?T=JS&NEWS=N&PAGE=fulltext&AN=00041444-200306000-00004&LSLINK=80&D=ovft

Full metadata record

DC FieldValue Language
dc.contributor.authorCurtis, David-
dc.contributor.authorKalsi, Gursharan-
dc.contributor.authorBrynjolfsson, Jon-
dc.contributor.authorMcInnis, Melvin-
dc.contributor.authorO'Neill, Jane-
dc.contributor.authorSmyth, Ciaran-
dc.contributor.authorMoloney, Eamonn-
dc.contributor.authorMurphy, Patrice-
dc.contributor.authorMcQuillin, Andrew-
dc.contributor.authorPetursson, Hannes-
dc.contributor.authorGurling, Hugh-
dc.date.accessioned2006-09-29T12:27:44Z-
dc.date.available2006-09-29T12:27:44Z-
dc.date.issued2003-06-01-
dc.identifier.citationPsychiatr. Genet. 2003, 13(2):77-84en
dc.identifier.issn0955-8829-
dc.identifier.pmid12782963-
dc.identifier.doi10.1097/01.ypg.0000056684.89558.d2-
dc.identifier.otherPSY12-
dc.identifier.urihttp://hdl.handle.net/2336/4671-
dc.description.abstractOBJECTIVE: To localize genes conferring susceptibility to bipolar affective disorder. METHODS: Seven families were selected on the basis of containing multiple cases of bipolar affective disorder present in three or more generations, an absence of schizophrenia and unilineal transmission. DNA samples from these families were genotyped with 365 microsatellite markers spaced at approximately 10 cM intervals across the whole genome. All markers were subjected to initial two-point and three-point analyses using LOD score and model-free analysis. All regions producing a result significant at P<0.01 were then subjected to four-point LOD score analysis under the assumption of heterogeneity. RESULTSA four-point LOD score of 2.8 was obtained using a dominant model and including unipolar cases as affected in the region of D12S342. Four-point LOD scores of 2 were obtained around D1S243, D1S251 and D3S1265. The positive results around D1S243 were accounted for by a LOD score of 3.1 occurring in a single pedigree. CONCLUSIONS: Since there has been previous strong support for linkage to the region of 12q23-q24 around D12S342, it now seems very probable that it does indeed contain a gene influencing susceptibility to bipolar affective disorder. Some evidence for linkage in the region of 1q near to D1S251 has been reported in one previous study. It therefore seems that this region of 1q and the region of 1p close to D1S243 may also harbour susceptibility genes.en
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen
dc.relation.urlhttp://gateway.ovid.com/ovidweb.cgi?T=JS&NEWS=N&PAGE=fulltext&AN=00041444-200306000-00004&LSLINK=80&D=ovften
dc.subject.meshBipolar Disorderen
dc.subject.meshChromosome Mappingen
dc.subject.meshChromosomes, Human, Pair 1en
dc.subject.meshChromosomes, Human, Pair 12en
dc.subject.meshFemaleen
dc.subject.meshGenetic Markersen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshGenome, Humanen
dc.subject.meshHumansen
dc.subject.meshLod Scoreen
dc.subject.meshMaleen
dc.subject.meshPedigreeen
dc.subject.meshResearch Support, Non-U.S. Gov'ten
dc.titleGenome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1qen
dc.typeArticleen
dc.identifier.journalPsychiatric geneticsen
dc.format.digYES-

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