Eye movement deficits in schizophrenia: investigation of a genetically homogenous Icelandic sample.

2.50
Hdl Handle:
http://hdl.handle.net/2336/46834
Title:
Eye movement deficits in schizophrenia: investigation of a genetically homogenous Icelandic sample.
Authors:
Haraldsson, H Magnus; Ettinger, Ulrich; Magnusdottir, Brynja B; Sigmundsson, Thordur; Sigurdsson, Engilbert; Petursson, Hannes
Citation:
Eur Arch Psychiatry Clin Neurosci. 2008, 258 (6):373-83
Issue Date:
1-Sep-2008
Abstract:
BACKGROUND: Deficits in antisaccade (AS) and smooth pursuit eye movements (SPEM) are promising endophenotypes in genetic studies of schizophrenia. The Icelandic population lends itself ideally to genetic studies due to its ethnic homogeneity and well-documented genealogy. The primary aim of this study was to assess AS and SPEM performance in a large Icelandic sample. Additional aims were to investigate the relationship between AS and SPEM task performance and to assess internal consistency, within-session performance changes and effects of SPEM target velocity on performance. METHOD: Patients with schizophrenia (N = 118) and healthy controls (N = 109) matched for age and gender underwent infrared oculographic assessment of AS and SPEM (at target velocities of 12 degrees , 24 degrees and 36 degrees /s). RESULTS: On the AS task patients displayed significantly more reflexive errors, longer latency, increased intra-individual latency variability, and reduced amplitude gain compared to controls. On the SPEM task, patients had significantly lower velocity gain and more frequent saccades during pursuit at all velocities, but group differences in velocity gain increased with increasing target velocity. Internal consistency of performance was high for all variables in both groups (Cronbach's alpha >0.77 for AS and >0.85 for SPEM) except for AS spatial error in patients (alpha = 0.38). A moderate association was found between AS and SPEM performance. By and large, patients and controls showed similar patterns of systematic within-session performance changes. CONCLUSIONS: Our findings confirm the existence of robust eye movement deficits in schizophrenia in a large sample. These measures may be studied as endophenotypes in future studies of potential schizophrenia risk genotypes in the genetically homogenous Icelandic population.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://www.springerlink.com/content/p387356n07096q44

Full metadata record

DC FieldValue Language
dc.contributor.authorHaraldsson, H Magnus-
dc.contributor.authorEttinger, Ulrich-
dc.contributor.authorMagnusdottir, Brynja B-
dc.contributor.authorSigmundsson, Thordur-
dc.contributor.authorSigurdsson, Engilbert-
dc.contributor.authorPetursson, Hannes-
dc.date.accessioned2008-12-22T10:25:09Z-
dc.date.available2008-12-22T10:25:09Z-
dc.date.issued2008-09-01-
dc.date.submitted2008-12-22-
dc.identifier.citationEur Arch Psychiatry Clin Neurosci. 2008, 258 (6):373-83en
dc.identifier.issn0940-1334-
dc.identifier.pmid18437278-
dc.identifier.doi10.1007/s00406-008-0806-y-
dc.identifier.urihttp://hdl.handle.net/2336/46834-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractBACKGROUND: Deficits in antisaccade (AS) and smooth pursuit eye movements (SPEM) are promising endophenotypes in genetic studies of schizophrenia. The Icelandic population lends itself ideally to genetic studies due to its ethnic homogeneity and well-documented genealogy. The primary aim of this study was to assess AS and SPEM performance in a large Icelandic sample. Additional aims were to investigate the relationship between AS and SPEM task performance and to assess internal consistency, within-session performance changes and effects of SPEM target velocity on performance. METHOD: Patients with schizophrenia (N = 118) and healthy controls (N = 109) matched for age and gender underwent infrared oculographic assessment of AS and SPEM (at target velocities of 12 degrees , 24 degrees and 36 degrees /s). RESULTS: On the AS task patients displayed significantly more reflexive errors, longer latency, increased intra-individual latency variability, and reduced amplitude gain compared to controls. On the SPEM task, patients had significantly lower velocity gain and more frequent saccades during pursuit at all velocities, but group differences in velocity gain increased with increasing target velocity. Internal consistency of performance was high for all variables in both groups (Cronbach's alpha >0.77 for AS and >0.85 for SPEM) except for AS spatial error in patients (alpha = 0.38). A moderate association was found between AS and SPEM performance. By and large, patients and controls showed similar patterns of systematic within-session performance changes. CONCLUSIONS: Our findings confirm the existence of robust eye movement deficits in schizophrenia in a large sample. These measures may be studied as endophenotypes in future studies of potential schizophrenia risk genotypes in the genetically homogenous Icelandic population.en
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.relation.urlhttp://www.springerlink.com/content/p387356n07096q44en
dc.subject.meshAdulten
dc.subject.meshAnalysis of Varianceen
dc.subject.meshEye Movementsen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshNeuropsychological Testsen
dc.subject.meshPsychiatric Status Rating Scalesen
dc.subject.meshPsychomotor Performanceen
dc.subject.meshPursuit, Smoothen
dc.subject.meshReaction Timeen
dc.subject.meshSaccadesen
dc.subject.meshSchizophreniaen
dc.titleEye movement deficits in schizophrenia: investigation of a genetically homogenous Icelandic sample.en
dc.typeArticleen
dc.identifier.eissn1433-8491-
dc.contributor.departmentLandspitali-University Hospital, Hringbraut, 101, Reykjavik, Iceland. hmagnus@landspitali.isen
dc.identifier.journalEuropean archives of psychiatry and clinical neuroscienceen

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