Clinical features of microscopic colitis in a nation-wide follow-up study in Iceland

2.50
Hdl Handle:
http://hdl.handle.net/2336/46905
Title:
Clinical features of microscopic colitis in a nation-wide follow-up study in Iceland
Authors:
Sveinsson, Olafur A; Orvar, Kjartan B; Birgisson, Sigurbjorn; Agnarsdottir, Margret; Jonasson, Jon Gunnlaugur
Citation:
Scand. J. Gastroenterol. 2008, 43(8):955-60
Issue Date:
1-Aug-2008
Abstract:
OBJECTIVE: The long-term natural history of collagenous colitis (CC) and lymphocytic colitis (LC) is not well known. The few reports available that address these issues have a limited follow-up. The aims of this study were to evaluate the natural history of microscopic colitis (MC), to describe the treatment medications prescribed and to assess the use of non-steroidal anti-inflammatory drugs (NSAIDs) in MC. MATERIAL AND METHODS: This study is based on an earlier epidemiological study conducted in Iceland where 125 patients with MC (71 with CC and 54 with LC) were diagnosed in the period 1995-99. All patients still alive and available were questioned about symptoms, treatment and NSAID use in the 3 months preceding the interview. RESULTS: In a mean follow-up time of 6.4 years from diagnosis, 15% of the patients had diarrhoeal symptoms more than once a week, 30% less than once a week and 55% had no diarrhoea. Abdominal pain was reported in 18% of the patients. There was no statistically significant difference in symptoms of CC and LC patients. Forty-eight patients (50%) were receiving medication for MC, 16% used aminosalicylates and 14% corticosteroids. Patients using medication for MC had significantly more diarrhoeal symptoms compared with those who did not (p = 0.002). Patients using NSAIDs regularly or as required, statistically did not have more symptoms related to MC than non-NSAID users. CONCLUSIONS: Only a minority of patients with MC had diarrhoea more than once a week in a long-term follow-up and the symptom pattern was similar between CC and LC patients. The use of NSAIDs was not associated with more diarrhoeal symptoms.
Description:
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field
Additional Links:
http://dx.doi.org/10.1080/00365520801958600

Full metadata record

DC FieldValue Language
dc.contributor.authorSveinsson, Olafur A-
dc.contributor.authorOrvar, Kjartan B-
dc.contributor.authorBirgisson, Sigurbjorn-
dc.contributor.authorAgnarsdottir, Margret-
dc.contributor.authorJonasson, Jon Gunnlaugur-
dc.date.accessioned2008-12-23T16:57:50Z-
dc.date.available2008-12-23T16:57:50Z-
dc.date.issued2008-08-01-
dc.date.submitted2008-12-23-
dc.identifier.citationScand. J. Gastroenterol. 2008, 43(8):955-60en
dc.identifier.issn0036-5521-
dc.identifier.pmid19086278-
dc.identifier.doi10.1080/00365520801958600-
dc.identifier.urihttp://hdl.handle.net/2336/46905-
dc.descriptionTo access publisher full text version of this article. Please click on the hyperlink in Additional Links fielden
dc.description.abstractOBJECTIVE: The long-term natural history of collagenous colitis (CC) and lymphocytic colitis (LC) is not well known. The few reports available that address these issues have a limited follow-up. The aims of this study were to evaluate the natural history of microscopic colitis (MC), to describe the treatment medications prescribed and to assess the use of non-steroidal anti-inflammatory drugs (NSAIDs) in MC. MATERIAL AND METHODS: This study is based on an earlier epidemiological study conducted in Iceland where 125 patients with MC (71 with CC and 54 with LC) were diagnosed in the period 1995-99. All patients still alive and available were questioned about symptoms, treatment and NSAID use in the 3 months preceding the interview. RESULTS: In a mean follow-up time of 6.4 years from diagnosis, 15% of the patients had diarrhoeal symptoms more than once a week, 30% less than once a week and 55% had no diarrhoea. Abdominal pain was reported in 18% of the patients. There was no statistically significant difference in symptoms of CC and LC patients. Forty-eight patients (50%) were receiving medication for MC, 16% used aminosalicylates and 14% corticosteroids. Patients using medication for MC had significantly more diarrhoeal symptoms compared with those who did not (p = 0.002). Patients using NSAIDs regularly or as required, statistically did not have more symptoms related to MC than non-NSAID users. CONCLUSIONS: Only a minority of patients with MC had diarrhoea more than once a week in a long-term follow-up and the symptom pattern was similar between CC and LC patients. The use of NSAIDs was not associated with more diarrhoeal symptoms.en
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.relation.urlhttp://dx.doi.org/10.1080/00365520801958600en
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidalen
dc.subject.meshColitis, Microscopicen
dc.subject.meshGlucocorticoidsen
dc.titleClinical features of microscopic colitis in a nation-wide follow-up study in Icelanden
dc.typeArticleen
dc.identifier.eissn1502-7708-
dc.contributor.departmentDepartment of Medicine, Division of Gastroenterology, Landspitali University Hospital, Reykjavik, Iceland.en
dc.identifier.journalScandinavian journal of gastroenterologyen

Related articles on PubMed

All Items in Hirsla are protected by copyright, with all rights reserved, unless otherwise indicated.